Thermal Cycling과 시효처리가 교정용 접착제의 인장강도에 미치는 영향

김종성(Jong-Sung Kim),전영미(Young-Mi Jeon),김정기(Jong-Ghee Kim) 대한치과재료학회 2000 대한치과재료학회지 Vol.27 No.3

Permanent Deformation Level Based on Initial Deformation and Time after Ligation, Thermocycling of Round Ni - Ti Wire

Chun-Chu Kim(김춘추),Ji-Hae Song(송지혜),Sae-Hyun Lee(이세현),Min-Ho Lee(이민호),Young-Mi Jeon(전영미),Jong-Ghee Kim(김정기) 대한치과재료학회 2011 대한치과재료학회지 Vol.38 No.1

구순구개열을 동반한 부정교합의 비외과적 교정치료

이승호,전영미,김정기,Lee Seung-Ho,Jeon Young-Mi,Kim Jong-Ghee 대한구순구개열학회 1999 대한구순구개열학회지 Vol.2 No.1

구순구개열은 악안면의 선천기형중 발생빈도가 가장 높은 것으로 알려져 있으며,출생시부터 성장이 완료되는 시기까지 일관된 치료계획에 의한 종합적인 진료체계가 필수적이다. 구순구개열이 존재할 경우 구개부의 조기 봉합후의 반흔조직 형성으로 인한 치열궁의 협착 또는 중안모의 함몰 경향과 함께 상악 측절치의 선천적 결손 또는 기형치, 전치의 회전과 경사 등이 수반되므로 교정치료에 의한 기능적, 심미적인 치열의 회복이 필요하게 된다. 구순구개열 환자의 교정치료에 있어서 상악치열의 정상적인 배열과 구치부 반대교합의 치료를 위해 상악골 확대가 종종 필요하며, 이를 위하여 Hyrax appliance, Quad-helix 및 Fan-type expansion screw, Jointed fan type expander 등 다양한 장치가 활용될 수 있다. 심하지 않은 구순구개열 환자의 교정치료에서 상악골 확대를 위한 장치의 선택은 환자의 치열궁 형태, 연령, 구치부와 전치부의 치열궁 폭경 등 다양한 요인이 고려되어야 하며, 치료 후 악궁형태의 보정에 특별한 주의를 기울여야 할 것이다. Cleft lip and palate is the most frequent congenital facial deformity of the orofacial area. Successful management of patients with cleft lip / palate requires a multidiciplinary approach from birth to adult stage. Coordinated treatment by the cleft palate team is an essential requirement to obtain optimum treatment results. One of the negative effect of the early surgical interventions of lip and palate is a significant incidence of maxillary growth restriction that produces secondary deformities of the jaws and malocclusion that includes congenital missing of lateral incisor, malformed teeth, rotation or ectopic position of upper anterior teeth, and it has been thought due to the resistance of palatal scar tissue. In Orthodontic treatment for cleft lip / palate patients, expansion of upper dental arch or palatal suture is often needed to correct posterior and/or anterior cross bite and align upper teeth. Various appliances such as hyrax, quad-helix, fan-type expansion screw and jointed-fan type expander can be used for palatal expansion. In the orthodontic treatment of the cleft lip / palate patient, we must consider patient age and severity of palatal constriction for proper appliance selection, and must pay special attention to maintain the treatment results.

Shear Bond Strength of Adhesive Precoated (APC II) Bracket Bonded with Self - etching Primer

Ki-Woon Kim(김기운),Ji-Hye Song(송지혜),Sea-Hyun Yi(이세현),Nan-Sil Park(박난실),Jong-Ghee Kim(김정기),Young-Mi Jeon(전영미) 대한치과재료학회 2011 대한치과재료학회지 Vol.38 No.1

Altered Expression of Epidermal Growth Factor Receptor and Nerve Growth Factor Receptor in the Rat Submandibular Gland treated with Secretagogues

김은경(Eun-Kyung Kim),김정기(Jong-Ghee Kim),조의식(Eui-Sic Cho) 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.5

본 연구는 phenylephrine과 isoproterenol을 지속적으로 투여한 후 흰쥐의 턱밑샘의 도관부로부터 성장인자를 분비시킨 후 턱밑샘에서 상피성장인자 수용체와 신경성장인자 수용체의 분포특성을 면역조직화학방법을 이용하여 알아봄으로써 상피성 장인자와 신경성장인자의 생리적인 기능을 구명하고자 수행되었다. Phenylephrine을 투여한 군에서는 광학현미경적으로 뚜렷한 변화를 관찰할 수 없었으나 isoproterenol을 투여한 군에서는 투여기간에 따라 샘조직의 현저한 증식을 관찰할 수 있었다. 상피성장인자 수용체는 상피성장인자가 존재하는 것으로 알려진 도관 벽세포에 분포하고 있었으나 이들은 isoproterenol 투여 직후 증가하였다가 투여기간이 길어질수록 감소하는 경향을 보였다. 신경성장인자 수용체는 도관 주변 결합조직세포에 분포하고 있었으며 phenylephrine 투여 후 증가하는 경향을 보였으나 isoproterenol 투여 후에는 감소하였다. 따라서 상피성장 인자 수용체와 신경성장인자 수용체는 각각 턱밑샘의 도관 벽세포와 도관주변 결합조직에 위치하며 이들은 외분비기전에 의해 구강내로 분비될 뿐만아니라 자가분비 또는 곁분비기전에 의해 샘조직 자체내에서 생리적인 기능을 수행할 것으로 사료된다. The immunohistochemical localization of epidermal growth factor receptor (EGFR) and nerve growth factor receptor (NGFR) in the submandibular gland of rats was investigated after chronic administration of isoproterenol (IPR) or phenylephrine (PEP). The weight of submandibular gland relative to body weight increased sharply by IPR administration for 14 days and reached twice of that in control, while no significant differences were observed after PEP administration. In PTAH staining, the intensity of duct compartments in rats exposed to IPR and PEP were paler than that of controls. But small secretory granules were observed in the GCT cells of IPR administrated groups. Acini showed characteristic features of hypertrophy, decreased in number of nuclei per unit area, after IPR administration, but not after PEP. EGFR immunoreactivities were distributed mainly in the duct compartments including GCT cells, intercalated duct cells and secretory duct cells. EGFR immunoactivities were more intense after both of PEP and IPR administration than those in controls. However, EGFR immunoactivities gradually decreased after IPR administration. NGFR immunoreactivities were distributed mainly in connective tissue cells surrounding ducts, but not in duct cells. Their intensities increased in the rat with PEP administration but decreased by IPR administration. These results demonstrated that EGFR or NGFR is localized mainly in the duct cells or the cells surrounding ducts, respectively, and that both population of EGFR and NGFR immunoreactive cells are altered by PEP and IPR. The results suggest that EGF and NGF may have some physiological roles by binding with their specific receptors in the submandibular gland as well as oral cavity.

상악 좌측 견치 및 제2소구치가 매복된 양측성 불완전 구순구개열 환자의 교정치료: 증례보고

전진(Jin Jeon),김정기(Jong Ghee Kim),전영미(Young-Mi Jeon) 대한구순구개열학회 2019 대한구순구개열학회지 Vol.22 No.2

Cleft lip and palate involves various and complex problems in craniofacial area and requires systematic management by experts in many fields from birth to growth completion. In addition, dental anomaly, which appears in various forms, complicates orthodontic treatment planning and acts as an important factor in prolonging the treatment period. The purpose of this case report is to show the long-term course of treatment and results of cleft lip and palate patients with various dental anomaly including maxillary peg lateralis, impaction of upper left canine, transposition of canine and lateral incisor, delayed formation of the upper left permanent premolar and palatal impaction. The patient had many uncertain factors that would change with growth to determine everything at the first visit, and received various treatment management for a period of about 10 years from the first visit to the Department of Orthodontics at 6 years and 10 months until 16 years and 10 months. The treatment goals were relatively clearly separated at each stage of treatment, with appropriate rest periods between treatment stages as needed. Appropriate modifications were made as needed within the overall treatment plan, and satisfactory results were obtained.

TGF - β 발현이 BAPN 으로 유도된 구개열 백서의 구개 형성에 미치는 영향에 대한 실험적 연구

이동근(Dong Kun Lee),김정기(Jong Ghee Kim),태기출(Ki Chul Tae) 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.3

N/A Cleft palate is one of the most serious congenital anomalies in human that causes a sucking problem in newborn babies and morphologic deformity that usually leads to death in newborn mouse offspring due to an insufficient ability to suck milk. Therefore cleft palate had been researched with epidemiologic and molecular methods, and many etiologic factors were examined closely. Among of the research methods, biologic molecule researches have been more important method for cleft palate formation study. The TGF-βhad an important role in the cell migration, epithelial-mesenchymal transdifferentiation, extracellular matrix synthesis and deposition. But there was a little research which was study about correlation cleft palate induced by beta-aminonitroproprionitrile (BAPN) with TGF-β expression. A purpose of this presented study was examed how TGF-β expression in cleft palate mice. At gestation days 13, BAPN-monofumarate salts ((C3 H6 N2 )2. C4 H4 O4, Sigma Co.) was single oral administered to 4 pregnant rats according to 1g/kg body weight. And pregnant rats were sacrificed on day 20 post coitus (p.c.), The TGF-β expression patterns of cleft formed fetus mice was followed that; 1. Osteoblast, mesenchymal cell and epithelial cell of cleft mice were low expression compare to control mice. 2. There was no TGF-βdifference expression pattern of osteocyte of cleft mice compare to control mice. 3. In western blot analysis, thickness of band of TGF-β in cleft mice was thin and dilute compare to control mice.

Epidermal Growth Factor Receptor and Nerve Growth Factor Receptor in the Rat Mandibular Molar and Incisor after Submandibular Sialadenectomy

최현규(Hyun-Gue Choi),김정기(Jong-Ghee Kim),조의식(Eui-Sic Cho) 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.5

턱밑샘은 신경성장인자와 상피성장인자의 주요 근원으로 알려져 있다. 본 연구에서는 턱밑샘을 외과적으로 제거한 후 이들 성장인자들이 결합하여 작용하는 것으로 알려진 신경성장인자 수용체와 상피성장인자 수용체가 하악치아를 포함하는 하악골에서 어떻게 변화하는 지를 알아봄으로써 하악치아에서 이들 성장인자의 생리적인 기능을 알아보고자 하였다. 대조군에서 상피성장인자 수용체에 대한 면역반응은 관찰할 수 없었으나 신경성장인자 수용체에 대한 면역반응은 치주인대와 절치의 법랑모세포에서 제한적으로 관찰되었다. 턱밑샘절제군에서 상피성장인자수용체와 신경성장인자 수용체에 대한 면역반응은 하악제1대구치의 상아모세포와 치주인대세포, 절치의 법랑모세포, 골수강의 일부 세포에서 관찰되었고 이들은 턱밑샘절제술 후 시간이 지남에 따라 반응성이 증가하였으며 반응세포에 있어서도 다양화되는 경향을 보였다. 이상의 결과로 보아 하악대구치와 절치에 분포하는 신경성장인자 수용체와 상피성장인자 수용체의 분포특성은 턱밑샘절제후에 분포특성이 변화함을 알 수 있었다. 따라서 턱밑샘기원의 상피성장인자와 신경성장인자는 직,간접적인 경로를 통해 치아의 유지와 하악골의 개조 등의 과정에서 생리적인 기능을 수행할 것으로 사료된다. Immunohistochemical changes of epidermal growth factor receptor (EGFR) and nerve growth factor receptor (NGFR) were investigated in the rat mandibular molar and incisors after submandibular sialadenectomy. In the sham operated rat, any EGFR immunoreactivity was not observed in the teeth but NGFR immunoreactivities were observed exclusively in the periodontal ligament and ameloblasts of incisor. In the sialadenectomized rat, EGFR immunoreactivities were observed in the odontoblasts of the mandibular first molar, periodontal ligament cells, ameloblasts of incisor and some cells of bone marrow. NGFR immunoreactivities were more intense and widely distributed in alveolar bone, periodontal ligaments and odontoblasts of the sialadenectomized rat than in the sham operated rat. Both of EGFR and NGFR immunoreactivities gradually increased in their intensities in a time-dependent manner after submandibular sialadenectomy. The results show that expression of EGFR and NGFR in the mandibular molar and incisor is enhanced by submandibular sialadenectomy. Therefore, it is suggested that EGF and NGF derived from submandibular gland may affect to the mandibular molar and incisors by direct and/or indirect mechanism.

상악 4전치 상실에 따른 임플랜트 수복을 위한 교정치료 증례

임병구(Byoung gu Lim),박철수(Cheol Soo Park),황조연(Jo yun Hwang),김정기(Jong Ghee Kim),전영미(Young Mi Jeon) 대한치과교정학회 2021 대한치과교정학회 임상저널 Vol.11 No.4

The maxillary anterior teeth are esthetically important. If the maxillary anterior teeth are lost due to trauma, it can be treated through conventional prosthetics or implants. However, if the restoration range is reduced with orthodontic treatment, more effective restoration treatment will be possible. An 18-year-old female patient had lost four maxillary anterior teeth about 10 years ago. Due to severe alveolar bone loss in the maxillary anterior region, the treatment plan was established to reduce the space for two central incisors rather than expanding to gain additional space for four incisors. This treatment plan not only corrected the protrusion of the upper lip but also reduced the number of implants that are needed.

난소적출과 에스트로젠 투여가 백서의 하악골 고조에 미치는 영향

이형순(Hyung-Soon Lee),홍성규(Sung-Gyu Hong),김정기(Jong-Ghee Kim) 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.1

본 실험은 폐경기 골다골증 여성의 교정치료에서 일어날 수 있는 하악골의 구조의 변화와 에스트로젠 투여 효과를 추정하기 위한 연구의 일환으로 난소를 적출한 군과 에스트로젠 투 여 및 비투여군으로 분류하고 미세방사선사진으로 하악골을 촬영하여 이의 골 면적을 측정 하고 조직 변화를 관찰하였다. 생후 4개월된 Sprauge-Dawley계 백서 50마리를 난소적출 (OVE)군, 난소적출후 에스트로젠 투여(OVE-EST)군, sham operation 시행후 에스트로젠 투여(EST)군으로 분류하여 각군을 수술후 5주, 6주, 7주째 희생시켜 하악골을 적출한 후 좌 측 하악골은 비탈회표본으로 제작하여 미세방사선사진을 통해 해면골을 관찰하고 면적을 측 정하였으며 우측 하악골은 탈회표본으로 제작하여 병리조직학적인 소견을 관찰하여 다음과 같은 결과를 얻었다. 1. 하악골의 전체골면적에 대한 피질골의 비율분석에서 OVE군, OVE-EST군, EST군 모두 에서 통계적으로 유의한 변화가 없었다. 2. OVE군은 대조군에 비해 5,6,7주째로 갈수록 골수강의 비율이 증가하였는데(P<0.05), 백 서의 난소제거가 하악골에서도 골소주를 소실시켜 골수강을 확장시켰다. 3. OVE-EST군은 5주째는 골수강의 비율이 약간 증가되어 있었으나 점차 감소하여서 7주 째에 유의하게 적었고(P<0.05), EST군은 6주째부터 골수강의 비율이 현저히 감소되었는데 (P<0.05), 에스트로젠이 골수강의 크기를 감소시키는 효과가 있음을 알 수 있었다. 4. 미세방사선사진과 병리조직학적 소견상 OVE군에서 골수강들의 크기가 확장되었고, 파골 세포들이 불규칙한 변연부에서 다수 관찰된 반면, OVE-EST군은 점점 치밀해지는 골소주 들로 골수강이 작아지는 양상을 나타냈고, EST군에서는 풍부하고 치밀한 골소주들로 골수 강들의 크기가 작아졌다. The purpose of this study was to evaluate the changes of cancellous and cortical bone and the effect of estrogen in ovariectomized rats. Fifty female rats, 250gm in body weight, were divided into three groups : ovariectomized group(OVE), ovariectomized and estrogen-injected group(OVE-EST), and sham operated and estrogen-injected group(EST), Bilateral ovariectomy was performed at the onset of the experiment. In OVE-EST group and EST group, estrogen was injected 50µg/kg B.W. every other days from 3 weeks after surgery to sacrifice Each five rats were sacrificed after 5, 6, 7 weeks. One side of mandibular body was radiographed with a soft x-ray apparatus (Hitex Co., Ltd., Japan). Thereafter the obtained microradiographs were used for the morphometric analysis using a Image analyzer. The morphometric analysis was performed for parameters such as total bone area, cortex bone area and medullary one area. The other side of the mandibular bone was decalcified and embedded in paraffin as using a general method. The specimens were sectioned and stained with Mallory´s anilline blue and observed light microscopically. The results were as follows. 1. In all groups, the proportion of cortex to total bone area was not significantly different. 2. In ovarietomized(OVE) group, the proportion of marrow cavity to medullary bone area increased significantly from 5 to 7 weeks(p<0.05). In ovariectomized and estrogen-injected (OVE-EST) group, it decreased significantly at 7 weeks, and in estrogen-injected(EST) group, it decreased significantly from 6 week(p<0.05). 3. Microradiogram and histopathologic findings revealed that marrow cavity was enlarged and osteoclasts were observed around irregular bone surface in OVE group. In OVE-EST group, the size of marrow cavity at 7 weeks was similar to that of control group, as dense trabecular bone increased from 5 to 7 weeks, marrow cavity decreased.