http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Young Ae Kan) (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
The change of serum inflammatory markers and cytokines following anti-tuberculosis drug therapy.
( Eun Hye Lee ),( Ah Young Leem ),( Joo Han Song ),( Song Yee Kim ),( Kyung Soo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Moo Suk Park ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Young Ae Kan 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Introduction: Active pulmonary tuberculosis (TB) is associated with cell-mediated immunity. Multiple cytokines and inflammatory markers are known to have roles in control TB infection. In this study, we aimed to investigate the change of multiple cytokines and inflammatory markers in active TB patients following anti-TB drug therapy. Methods: Patients with active TB were prospectively recruited between December 2010 and February 2013 at Severance Hospital, in Seoul, South Korea. Treatment was based on the standard regimen of rifampicin (10 mg/kg body weight [BW]/day), isoniazid( 5 mg/kg BW/day), ethambutol (15-25 mg/kg BW/day),and pyrazinamide (15-30 mg/kg BW/day). Blood samples were collected from active TB patients (total n=18) at before (T0), after 2 months (T2), and after 6 months (T6) of anti-TB treatment. We measured the levels of IFN-γ, IL-2, IL-12, IL-10, IL-13, and TNF-αin the supernatant from the QuantiFERON-TB Gold In-Tube assay (QFT-GIT) and WBC count, neutrophil count, lymphocyte count, platelet count, red cell distribution width (RDW), mean platelet volume(MPV), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR). Results: Compared to baseline levels, IL-10, TNF-α in the supernatant from QFT-GIT, WBC count, neutrophil count, platelet count were produced in significantly lower amounts in response to the treatment. As for IFN-γ, IL-2, IL-12, IL-13 responses, the decrease of median values were not statistically significant. Also the results showed that the IL-10/ IFN-γ ratio of supernatant of QFT-GIT and neutrophil to lymphocyte ratio (NLR)after treatment significantly decreased compared to the baseline, whereas the IL-2/ IFN-γ ratio of supernatant of QFT-GIT increased after treatment. Conclusions: In conclusion, IL-10, TNF-αin the supernatant from QFT-GIT, WBC count, neutrophil count, platelet count decreased following anti-TB drug therapy. And also the IL-2/IFN-γ ratio, IL-10/IFN-γ ratio of supernatant of QFT-GIT, neutrophil to lymphocyte ratio (NLR) may be used as biomarkers to evaluate the effectiveness of drug therapy in active TB patients.
-
간경애,김영혜,Kan Kyoung Ae,Kim Young Hae 한국아동간호학회 2000 Child Health Nursing Research Vol.6 No.1
The purpose of this study was to investigate the actual state of and the factors in relation to drinking and smoking of elementary school. The subject for this study consisted of 604 students of six elementary schools located in Pusan. The data were collected by using a anonymous questionnaire during the period from Nov. 1, 1998 to Nov. 15, 1998. The results of this study are summarized as follows. 1. The rate of drinking of the whole respondents was 20.7% (male 25.4%, female 15.6%), the rate of smoking was 8.1%(male 11.7%, female 4.2%). The user of drink and cigarets together showed 5.6%. 2. The school year of the first drinking and smoking was most at the 5th grade in elementary school(drinking 24.8%, smoking 20.4%). The motivation of beginning drinking and smoking was curiosity for the most part(32.0%, 61.2%). As to a way to get drink and cigarets, using a thing in the house' was most(82.2%). As to a used place, their own home or their friends' home showed 32.2% for the most part. Companion was mostly alone(84.0%). 3. Those who had experience of drinking and smoking took more positive attitude toward drinker and smoker, were more hospitable to exhortation to drinking and smoking, and were more positive about the late intention of drinking and smoking, but his desire for health education was lower than not. And he showed overlooking or keeping step with his friend's drinking and smoking. 4. In the results so far investigated difference of drinking and smoking according to a general tendency of respondents. The experience of drinking was related to sex distinction (P=0.003) and the marital status of parents (P=0.001). And the experience of smoking had relation to sex distinction(P=0.001), the marital status of parents(P=0.001), the parent's attitude of bring up(P=0.020) and making use of leisure (P=0.029)(P<.05).
-
( Eun Hye Lee ),( Mi Hwa Shin ),( Jong-min Park ),( Sang-guk Lee ),( Nam Su Ku ),( Ah Young Leem ),( Sang Hoon Lee ),( Joo Han Song ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kan 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Purpose: Sepsis remains a critical problem worldwide and one of the main causes of death in intensive care units (ICU). We investigated plasma lysophosphatidylcholine (LPC) 16:0 level using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in ICU sepsis patients. Methods: Patients admitted medical ICU were prospectively enrolled from March 2017 through June 2018 at Severance Hospital. The inclusion criteria for the study were a fulfillment of at least 2 criteria of systemic inflammatory response syndrome (SIRS) or presence of sepsis. The definition of sepsis followed the revised sepsis 3-definition. Results: Of the 120 enrolled patients, 15 patients were non-infectious SIRS, 37 patients were classified as sepsis and 68 were septic shock. Of these 105 patients who meet the sepsis diagnostic criteria, 70 patients survived and 35 patients were dead at 28-day. Mean plasma LPC concentration (μmol/L) of septic shock patients was significantly lower than those of non-infectious SIRS (26.55 vs. 70.65, p<0.001) and sepsis patients (26.55 vs. 48.50, p<0.01). The area under the curve (AUC) predicting 28-day mortality of ΔLPC16:0 (D7-D0) was 0.792 that was higher than APACHE II score (AUC;0.694) and SOFA score (AUC;0.678). In the multivariate analysis, LPC16:0 change less than cut-off value (Δ LPC16:0 (D7-D0) ≤14.859; HR, 5.467) were associated with increased 28-day mortality. Conclusion: Our results indicate that Δ LPC16:0 in sepsis patients using MALDI-TOF MS could help to better predict prognosis and mortality of sepsis patients in ICU.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
