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Aged Garlic Supplement Protects Against Lipid Peroxidation in Hypercholesterolemic Individuals
Xing Lin Ho,Shin Yih Tsen,Mei Yen Ng,Wei Ni Lee,Aileen Low,Wai Mun Loke 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.10
The health benefits of raw garlic intake has been extensively studied, but little is known about the biological effects of aged garlic consumption. A randomized, placebo-controlled, parallel-arm, double-blinded trial involving 41 hypercholesterolemic individuals was conducted to simultaneously examine and compare the blood lipid lowering and antioxidant effects after acute and extended exposures to aged and raw garlic supplements (1080 mg daily). Aged and raw garlic did not affect blood lipid concentrations in these hypercholesterolemic participants after acute and 13-week supplementation. The plasma and urinary F2-isoprostanes concentrations were significantly decreased after 13 weeks of aged garlic treatment. Aged garlic supplementation over 13 weeks also significantly decreased serum lipid hydroperoxide concentration and myeloperoxidase activity. Raw garlic treatments did not affect the F2-isoprostanes concentrations in blood plasma and urine, and lipid hydroperoxides in blood sera. Acute effects on the measured parameters were absent for both garlic treatments. In separate in vitro experiments, aqueous methanolic extract of aged garlic inhibited F2-isoprostanes formation and myeloperoxidase activity in freshly isolated human neutrophils to a greater extent than the raw garlic extract and S-allylcysteine at equivalent dosing concentrations. The aged garlic preparation was found to contain significantly higher total phenolic and S-allylcysteine contents than the raw garlic precursor. Our data showed that supplementation with aged garlic, not its raw garlic precursor, reduced oxidative stress and alleviated lipid peroxidation, possibly via the inhibition of myeloperoxidase. The differential antioxidant actions of the aged and raw garlic may be related to their different total phenolic contents and, to a lesser extent, their S-allylcysteine contents.
라오스 개벌림에서 다섯가지 자생수종과 각기 다른 조림처리의 Enrichment Planting이 묘목의 생장특성에 미치는 효과
찬사몬폰고우돔 ( Chanhsamone Phongoudome ),실라반사와드봉 ( Silavanh Sawathvong ),우수영 ( Su Young Woo ),와이문호 ( Wai Mun Ho ),박영대 ( Yeong Dae Park ) 한국농림기상학회 2012 한국농림기상학회지 Vol.14 No.2
Enrichment planting is commonly used for increasing the density of tree species in secondary forests and one of forest rehabilitation programs in Lao PDR. This study aimed to determine the performance of five native species in enrichment planting using different canopy opening treatments, and to examine the suitable species and silviculture techniques applicable to a logged-over forest in Lao PDR. Results of the study showed that only crown height had significant difference among species and planting treatments. The survival rate and crown diameter were significantly different by species, but not by planting treatments. However, root collar diameter (RCD) and height of seedlings showed significant differences among planting treatments. Among the study species, Hopea odorata and Dalbergia cochinchinensis showed significantly higher survival rate and height growth, indicating their suitability in enrichment planting for rehabilitation of forest in Lao PDR. The results also suggested that 2 m width line planting stimulated RCD growth, but wider line planting, such as gap planting, promoted height growth of seedlings.