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        A comparison of the breathing apparatus deadspace associated with a supraglottic airway and endotracheal tube using volumetric capnography in young children

        Goenaga-Diaz Eduardo Javier,Smith Lauren Daniela,Pecorella Shelly Harrell,Smith Timothy Earl,Russell Gregory B,Johnson Kathleen Nicole,Downard Martina Gomez,Ririe Douglas Gordon,Hammon Dudley Elliott 대한마취통증의학회 2021 Korean Journal of Anesthesiology Vol.74 No.3

        Background: Supraglottic airway (SGA) devices including the air-Q® are being used with increasing frequency for anesthesia in infants and younger pediatric patients. To date, there is minimal research documenting the potentially significant airway deadspace these devices may contribute to the ventilation circuit when compared to an endotracheal tube (ETT). The aim of this study was to evaluate the airway apparatus deadspace associated with an air-Q® versus an ETT in young children.Methods: In a prospective cohort study, 59 patients between 3 months and 6 years of age, weighing between 5 and 20 kg, scheduled for outpatient urologic or general surgery procedures were recruited. An air-Q® or ETT was inserted at the discretion of the attending anesthesiologist, and tidal volume, positive end expiratory pressure, respiratory rate, and end-tidal CO2 were controlled according to protocol. Airway deadspace was recorded using volumetric capnography every 2 min for 10 min. Results: Groups were similar in demographics. There was a significant difference in weight-adjusted deadspace volume between the air-Q® and ETT groups, 4.1 ± 0.8 ml/kg versus 3.0 ± 0.7 ml/kg, respectively (P < 0.001). Weight-adjusted deadspace volume (ml/kg) increased significantly with decreasing weight for both the air-Q® and ETT groups.Conclusions: In healthy children undergoing positive pressure ventilation for elective surgery, the air-Q® SGA introduces significantly greater airway deadspace than an ETT. Additionally, airway deadspace, and minute ventilation required to maintain normocarbia, appear to increase with decreasing patient weight irrespective of whether a SGA or ETT is used.

      • Evaluation of female masculinization in Pomacea canaliculata (Caenogastropoda, Ampullariidae) induced by tributyltin, heavy metals, and uranium in culture water

        Maximiliano Giraud-Billoud,Alejandra Daniela Campoy-Diaz,Emilio Mansilla Munoz,Israel Anibal Vega 환경독성보건학회 2022 환경독성보건학회지 Vol.37 No.3

        All female Pomacea canaliculata develop a small, male-like copulatory apparatus a few days after birth, which growths slowly until sexual maturity, and even further in older age. Previous studies have found trace elements like mercury (Hg), arsenic (As) and uranium (U) in tap water used for snail culture, and that these elements were accumulated in snail tissues. Here, we test whether the presence of these metals at maximum allowed concentrations (Environmental Protection Agency - EPA) in aquarium water could affect the development of the copulatory apparatus in mature females. Females of different ages were used as controls, grown in reconstituted metal-free water with or without the addition of Hg, As and U, as well as tributyltin (TBT), a compound used as masculinizing agent. Six and seven months old females cultured in tap water showed a longer penis and penile sheath, and a greater overall development of the copulatory apparatus, measured by an index (DI), as compared with same-age females cultured in reconstituted water. Moreover, when females were exposed to Hg, As or U at the maximum contaminant levels for human consumption allowed by EPA regulations, there was no further development of the copulatory apparatus, while there was a clearly positive effect in TBT-exposed females. This study confirms the masculinizing effect of organotin compounds on female copulatory apparatus and discusses the usefulness of the development of these organs as a bioindicator of environmental pollution.

      • Poster Session : PS 0126 ; Cardiology : Comparison of Blood Pressure at the Beginning and at the End of Visits in a HIV Clinic

        ( Manuel Roca ),( M Daniela Diaz ),( M Alexandra Mendoza ),( Bernardino Roca ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Objectives: Stress and other causes can infl uence blood pressure levels and may limit the usefulness of its measurement in the offi ce, but knowledge in this fi eld is limited. We aim to determine the impact on and blood pressure of the state of anxiety that HIV-infected patients experience when they are about to be informed of immunologic and virologic tests and other blood analysis results in clinical visits. Methods: In a cohort of HIV-infected patients, we measured blood pressure of every subject twice: at the beginning of visits just before we reported them lymphocyte CD4 cell count, HIV-viral load and other blood analysis results, and about ten minutes afterwards at the end of visits. We compared results of both determinations, and searched for factors associated with differences between both determinations, when present. Results: We included 152 patients, the median of age was 45 years (interquartile range: 39-50), 101 (66 %) were male, 24 (16 %) had been diagnosed of hypertension previously, 28 (18 %) had been diagnosed of diabetes, 25 (16 %) had been diagnosed of dyslipidemia, and 120 (79 %) were smokers; 142 (93 %) were taking antiretroviral medication. Table shows results at the beginning and at the end of visits (sBP and dBP = systolic and diastolic blood pressure, measured in mmHg). An association was found between lower sBP at the end of the visit compared to blood pressure at the beginning of the visit and the following variables: younger age (P = 0.018) and female gender (P = 0.008). Conclusion: sBP at the end of the visit is commonly lower than sBP at the beginning of the visit, especially in young women.

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