http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Jung Yeob Ham ),( Hoo Sang Hwang ),( Euno Kim ),( Jeong Ah Kim ),( Sung Jin Cho ),( Jae Young Ko ),( Woo Jin Lee ),( Jae Hwan Lee ),( Harish Holla ),( Joydeep Banerjee ),( Seok Ho Kim ),( Jin Ho Yan 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
We have discovered and demonstrated the in vitro and in vivo PPARδ-selective activity of novel Y-shaped agonists. These compounds activated hPPARδ with EC(50) values between 1 and 523 nM. Surprisingly, compounds 10a, 11d, 11e and 11f were the most potent and most selective hPPARδ agonists with 10(4)-fold selectivity over the other two subtypes, namely, hPPARα and hPPARγ. The PPARδ ligands 10a, 11e and 11f showed good bioavailability and in vivo efficacy. ⓒ 2012 Elsevier Masson SAS. All rights reserved.