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Polyacrylate 수화겔의 약물방출특성에 관한 연구
차효복,이성길,이용택 慶熙大學校 材料科學技術硏究所 1998 材料科學技術硏究論集 Vol.11 No.-
SAc hydrogels were prepared by crosslinking of concentrated aqueous solutions of poly(acrylamide)(PAm) and poly(sodium-acrylate)(PSAc) in N_(2) gas. The equilibrium swelling studies of SAc hydrogels were carried out in solution of varing pH. The gel was swollen extensively in the solution of pH 6 when compared to that of pH 2. Riboflavin and L-ascorbic acid was loaded and the in vitro release studies were carried out in pH solution. The results of this study suggest that drug release is proportion to swelling ratio. SAc hydrogel with drug is corresponded to the soluble matrix pharmaceutical preparation.