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      • SCOPUSKCI등재

        Pheochromocytoma 의 마취관리 1예 보고

        조용호,김태성,길호영,진상호,윤영준,최병석 대한마취과학회 1989 Korean Journal of Anesthesiology Vol.22 No.6

        The anesthetic management of patients with pheochromocytoma presents many difficult problems, such as hypertension, cardiac arrhythmias, and hypotension. A 21 year-old male underwent resection of pheochromocytoma under general anesthesia with isoflurane and fentanyl. Hypertensive crisis during induction of anesthesia and surgical manipulation of the tumor were managed with phentolamine and sodium nitroprusside drips. Anesthesia was maintained wtih nitrous oxide : oxygen, 50% : 50%, isoflurane, 0.5-2% and supplemented with fractional doses of fentanyl and vecuronium for muscular relaxation. We also used propranolol for the cardiac arrhythmia. An endotracheal semi-closed circle absorption technique with controlled ventilation was employed. Fentanyl does not release histamine, and has stable hemodynamics. Isoflurane has also advocated on the grounds that arrhythmias are less esaily provocated by circulating catecholamines than with other volatile agents, and has been shown to be a satisfactory agent. Vecuronium does not provoke catecholamine release, does not release histamine, has no autonomic effects at clinical plasma concentrations, and is clearly the neuromuscular blocking agent of choice in this case. Optimal pre-operative preparation, smooth induction of anesthesia, adequate alveolar ventilation, proper cardiovascular control, and good communication between surgeon and anesthesiologist are most important for the anesthetic management of pheochromocytoma.

      • Nicotinamide Adenine Dinucleotide 생합성에 미치는 Cycloheximide의 영향

        조용호,Cho, Yong-Ho 생화학분자생물학회 1972 한국생화학회지 Vol.5 No.1

        The effects of cycloheximide on the biosynthesis of hepatic NAD from nicotinamide have been investigated in mice by following the changes in the level of NAD and observing the incorporation of nicotinamide-7-$^{14}C$ into the biosynthetic intermediates of NAD, namely, niacin mononucleotide, desamido-NAD and NAD. Cycloheximide (1 mg/kg) inhibited markedly the increase in the hepatic NAD induced by nicotinamide (500 mg/kg). Cycloheximide when given alone, however, did not cause any change in the normal levels of liver NAD. The analysis for the incorporation of nicotinamide-7-$^{14}C$ into biosynthetic precursors of NAD revealed that cycloheximide inhibited the increased biosynthesis of NAD induced by nicotinamide by causing the accumulation of desamido-NAD and niacin mononucleotide in livers. It is suggested from these results that cycloheximide inhibits hepatic NAD biosynthesis from nicotinamide by blocking mainly the enzyme system that converts desamido-NAD to NAD, e.g., NAD synthetase. Nicotinamide로부터 NAD가 생합성되는데 미치는 cycloheximide의 영향을 보기 위하여 mouse에 nicotinamide와 cycloheximide를 투여한 후에 간 NAD량을 측정하고, 또 동시에 nicotinamide-7-$^{14}C$이 NAD 생합성계의 중간체(niacin mononucleotide와 desamido-NAD)와 NAD에 진입되는 율을 관찰하였다. Nicotinamide 투여에 의한 간 NAD의 증량은 cycloheximide(1mg/kg)로 말미암아 현저히 억제되었다. 그러나 cycloheximide 단독 투여는 간의 정상 NAD량에 아무런 영향을 주지 아니 하였다. Nicotinamide-7-$^{14}C$이 NAD합성 중간체에 진입되는 양상을 분석한 결과 cycloheximide는 nicotinamide로부터 생성되는 desamido-NAD와 niacin mononucleotide의 축척을 가져오므로써 nicotinamide 유발의 NAD 증량을 억제함을 알 수 있었고, 따라서 cycloheximide는 주로 NAD 생합성 효소계 중 desamido-NAD가 NAD로 전환되는 반응에 억제적으로 작용함이 시사되었다.

      • SCIESCOPUSKCI등재
      • KCI등재

        성지여고 배드민턴부의 역사적 고찰

        조용호,문성국,이가람 중앙대학교 학교체육연구소 2020 Asian Journal of Physical Education of Sport Scien Vol.8 No.2

        본 연구는 한국 여자배드민턴의 요람인 마산 성지여고 배드민턴부에 관한 신문, 잡지, 사진 등의 1차 자료와 구술 자료를 고찰해, 성지여고가 한국 여자배드민턴의 발전에 미친 영향을 파악했다. 1962년에 설립된 성지여고 배드민턴부는 1960년대 후반부터 성장기를 경험하며, 전국춘계종별배드민턴대회, 전국체육대회, 전국종별배드민턴 대회에서 우승을 차지하기 시작했다. 특히 1969년 아시아 청소년배드민턴선수권대회에서는 1위부터 4위까지 모두 성지여고 선수들이차지하기도 했다. 전성기(1970-1983)에 성지여고는 참가는 곧 우승이라는 공식을 써 가며 당대수많은 대회에서 우승을 독식했다. 특히 성지여고는 춘계종별배드민턴리그전 9연패, 전국체육대회 8연패 등의 성적뿐만 아니라, 1981년 한국 최초의 전영오픈 우승을 차지한 황선애 선수를배출하기도 했다. 부활기(1988-2000)에도 성지여고는 꾸준히 김호자, 이정미, 이경원, 정경은, 배연주, 성지현 선수 등과 같은 국가대표급 선수들을 배출하며, 국내․외 대회에서 우수한 성적을 올리며 한국 여자 배드민턴의 성지로 명성을 이어왔다. This study identified the impact of Seongji Girls' High School in Masan, the cradle of Korean women's badminton, on the development of Korean women's badminton by examining the primary data such as newspapers, magazines, and photographs, and oral data. Founded in 1962, Seongji Girls' High School's badminton team had grown since the late 1960s and began to win titles in the national spring badminton championship, the national sports competition and the national badminton championships. In particular, its players ranked first to fourth at the Asian Youth Badminton Championship in 1969. In its heyday(1970-1983), it dominated many of the events of its time by winning every competition it participated. Moreover, not only did it win nine straight games in the spring badminton league and eight straight games at the National Sports Competition, it also produced Hwang Sun-ae, the first Korean player who won the All England Badminton Championship in 1981. Even during the revival period(1988-2000), it continued to be a sacred place for Korean women's badminton, producing national team-level players such as Ho-ja Kim, Jung-mi Lee, Kyung-won Lee, Kyung-ju Jung, Yeon-ju Bae and Ji-hyun Sung, and achieving excellent results at national and international competitions.

      • 갯기름나물의 근(根)과 경엽(莖葉)의 면역 및 항암 활성 비교연구

        조용호,Cho, Yong-Ho 대한한방피부미용학회 2005 대한한방피부미용학회지 Vol.1 No.1

        This study compared the activity of the aerial part of P. japonicum with its root in order to examine the possibility of the medicinal use of the aerial part, which has not been used as medicine, in substitute for the root that has traditionally been used as medicine. For this purpose, the author measured the proliferation of Human $CD4^-$ T cells, which are related to immunity, the differentiation of HL-60 cells, and the contents of IL-6, IgE and $TNF-{\alpha}$ and compared their anti-cancer effect on Hep3B and A549 cells. The results of this study are as follows: 1. As for Human $CD4^-$ T cells, $1.0\;g/{\ell}$ methanol extract from the aerial part promoted the proliferation of the cells 1.8 times higher while $1.0\;g/{\ell}$ methanol extract from the root did by 1.76 times higher compared to the control group. 2. As for HL-60 cells, methanol extract and water extract from the aerial part showed differentiation 1.14 times higher and 1.12 times higher respectively while methanol extract and water extract from the root did 1.14 times higher and 1.07 times higher compared to tile control group. 3. Cell density was highest on Day 4 of culture in all samples, Methanol extracts from the aerial part and the root showed activities of $7.9{\times}10^3\;cells/m{\ell}$ and $7.5{\times}10^3\;cells/m{\ell}$ respectively, and water extracts from the aerial part and the root did activities of $5.3{\times}10^3\;cells/m{\ell}$ and $6.1{\times}10^3\;cells/m{\ell}$. 4. The secretion of IL-6 was highest on Day 4 of culture. Methanol extracts from the aerial part and the root showed secretions of $6.7{\times}10^{-3}\;pg/cells/m{\ell}$ and $7.2{\times}10^{-3}\;pg/cells/m{\ell}$ respectively, and water extracts from the aerial part and the root did secretions of as high as $7.0{\times}10^{-3}\;pg/cells/m{\ell}$ and $6.0{\times}10^{-3}\;pg/cells/m{\ell}$. 5. As for the production of IgE, water extract from the root effectively inhibited the product at $1,000\;{\mu}g/m{\ell}$, methanol extract from the root at $10\;{\mu}g/m{\ell}$ and $100\;{\mu}g/m{\ell}$, water extract from the aerial at $1,000\;{\mu}g/m{\ell}$, and methanol extract from the aerial part at $1,000\;{\mu}g/m{\ell}$. 6. According to the result of measuring the content of $TNF-{\alpha}$, methanol extracts from the root and the aerial part showed inhibition effect at $10\;{\mu}g/m{\ell}$, $100\;{\mu}g/m{\ell}$ and $1,000\;{\mu}g/m{\ell}$. 7. As for liver cancer cell Hep3B, $1.0\;g/{\ell}$ methanol extracts from the root and the aerial part showed inhibition effects of 78% and 70% respectively, and $1.0\;g/{\ell}$ water extracts from the root and the aerial part did inhibition effects of 56% and 59%. 8. As for lung cancer cell A549, $1.0\;g/{\ell}$ methanol extracts from the root and the aerial part showed inhibition effects of 75% and 70% respectively, and $1.0\;g/{\ell}$ water extracts from the root and the aerial part did inhibition effects of 48% and 45%. The results of this study presented above show that the aerial part of P. japonicum has immunizing and anti-cancer effects as high as its root, which has commonly been used as medicine. There should be more in-depth research on the aerial part of P. japonicum in the future.

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