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張善文 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.2
An audiologic study was performed for the patients of head injury, who were admitted to dept. of neurosurgery, Chung-Nam University Hospital during April 1975-April 1976. Sixty cases, 26 with the temporal bone fracture, 16 with the skull fracture not involving the temporal bone, and 18 with head injury without fracture, were sampled, who had no history of ear trouble and noise exposure, and could cooperate in doing pure tone audiometry. Hearing test was done at 3rd week-3rd month after head injury. The results were as followings: 1. On otologic symptoms and fin dings, ear bleedings was observed in 20 cases(76.9%) with the temporeal bone fracture and 12 cases(46.1%) showed the pathology of the external auditory canal and 8 cases (30.7%) showed the pathology of the ear drum. Facial nerve paralysis was observed in 2 cases with the temporal bone fracture and 36 cases(60%) complained hearing loss and 25 cases(41.6%) and 29 cases(48.3%) complained of tinnitus and vertigo after head injury. 2. On the type of hearing loss, 8 cases(18.3%) had normal hearing bilaterally, and 34 cases(56.6%) of bilateral sensorineural, 9 cases(15%) of bilateral or unilateral mixed, and 3 cases (5%) of unilateral conductive hearing loss were observed. 3. There were 36 cases(60%), that had descending curve or abrupt drop on audiogram and the maximal hearing loss was observed at high frequencies, especially at 6,000 Kz, mostly in the cases of the temporal bone fracture. 4. Twenty-three cases(38.3%), bilaterally and 14 cases(23.3%) unilaterally showed hearing loss at the speech frequencies but there was a few in the skull fracture without the temporal bone fracture. And there 29 casese (48.3%); that had hearing loss at high frequencies without hearing loss at speech frequencies. 5. In the cases of the temporal bone fracture, there was tendency that hearing loss on the fractured ear was greater than on the contralateral ear but the satistical significancy couldn't be noted. 6. Hearing loss after head injury had the tendency that the longer the duration of unconsciousness, the greater the hearing loss. 7. Tinnitus after head injury showed its pitch at 500 Hz and 1,000 Hz and 25∼35 dB in its intensity.
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Aflatoxin B_1 투여가 急性 肝 病變에 미치는 영향에 對한 病理學的 硏究
장선문,이충식,강대영 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1
In an attempt of elucidate the pathologic and histochemical changes of aflatoxin B_2-induced hepatie lesions, the present study in male Sprague-Dawley rats was undertaken to evalute the relation between pathologic change of the liver and histochemical changes of several enzymes : alkaline phosphatase, acid phosphatase and succinic dehydrogenase at 3. 9. 24. 48. 72, and 144 hours after single administration of aflatoxin B_1 by gastric tube. The aflatoxin B_1 was dissolved in peanut oil(0.5㎎ aflatoxin B_1 to 0.5ml peanut oil). Grouop of male rats received aflatoxin B_1 1㎎ per ㎏ of body weight, respectively. Control animals were given a similar volume of peanut oil alone. The results on morphologic and histochemical changes were as follows: 1. The necrotic change of liver was mainly periportal, and it became most severe at 24 hours and was more prominent in the large dose group than the small dose group. 2. Biliary ductular cell proliferation started to appear within 72 hours and after became regressed later in the small dose group, but it remained approximately 144 hours after exposure in the large dose group. 3. Electron microscopically, all three groups showed irregular nuclear membrane and nucleolar change characterized by segregation of granular and fibrillar elements. All the group showed cytoplasmie changes such as dilatation of rough endoplasmic reticulum with detached ribosome, hyperplasia of smooth endoplasmic reticulum, increased numbers of lipid droplets and mitochondrial alteration. The above change in the large dose group was more severe than those of the small dose group. 4. In the histochemical study of experimental animals, there was a decrease in the intensity of the staining reaction of alkaline phosphatase and succinic dehydrogenase within 24 hours and a progressive decrease in staining intensity was noted at 144 hours. And then the staining intensity of the acid phosphatase was similar to that shown by the control animal. In summary, the data obtained by present experiments indicate aflatoxin B_1 exerts periportal necrosis of hepatic lobules accompanied by bile ductular cell proliferation, and inhibition of protein synthesis, as jedged by elertron microscopic and histochemical changes.
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곡류가루 첨가가 소시지의 품질 및 저장성에 미치는 영향
장선문,임지숙,조은자 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.3
To investigate the effect of cereal powders on the quality and storage characteristics of sausage, Aw, pH, microbial count, TBA value, VBN value, textual and sensory characteristics were examined. Water activity tended to decrease as storage time prolonged and all the samples showed higher Aw's than that of the control. During the storage period, pH values of all the samples decreased. L, a and b values had a tendency to decrease during the storage period. During the four weeks storage at 4℃, TBA and VBN values of all the sample showed increasing tendency and were lower than those of the control. Total plate counts of bacteria, the number of lactic acid bacteria and coliform bacteria counts increased as the storage time prolonged. Texture characteristics of all samples increased up to 1 week storage and decreased subsequently. The sensory scores of all the samples decreased as the storage time prolonged.
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