http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이균범,김성균,Lee, Gyun-Bum,Kim, Sung-Kyun 대한기계학회 2014 대한기계학회 논문집. Transactions of the KSME. C, 산업기술과 혁신 Vol.2 No.2
Drug delivery in human upper airway was studied by the numerical simulation of oral airflow. We created an anatomically accurate upper airway model from CT scan data by using a medical image processing software (Mimics). The upper airway was composed of oral cavity, pharynx, larynx, trachea, and second generations of branches. Thin sliced CT data and meticulous refinement of model surface under the ENT doctor's advice provided more sophisticated nasal cavity models. With this 3D upper airway models, numerical simulation was conducted by ANSYS/FLUENT. The steady inspiratory airflows in that model was solved numerically for the case of flow rate of 250 mL/s with drug-laden spray(Q= 20, 40, 60 mL/s). Optimal parameters for mechanical drug aerosol targeting of predetermined areas was to be computed, for a given representative upper airways. From numerical flow visualization results, as flow-rate of drug-laden spray increases, the drag spray residue in oral cavity was increased and the distribution of drug spray in trachea and branches became more homogeneous. 상기도 내의 약물 전달을 알아보기 위하여 구강 호흡 시 공기유동에 대한 수치해석을 수행하였다. 상기도는 구강과 후두, 기관과 기관지로 구성되어 있다. 정밀 촬영한 CT 데이터로부터 의료영상 소프트웨어(Mimics)를 이용한 구분(segmentation)과 세심한 표면처리를 통하여 해부학적으로 정확한 모델을 만들 수 있었다. 이 3차원 컴퓨터 모델을 이용하여, 구강에서 기관지의 2번째 분지까지 이르는 유로의 수치 모델을 제작하였다. 수치해석은 상용 소프트웨어인 ANSYS/Fluent를 이용하여 계산하였다. 본 연구에 사용된 모델은 노즐이 부착되지 않은 상태에서 초당 250 mL를 흡입하는 정상 구강호흡 모델과 입구에 각각 20 mL/s, 40 mL/s, 60 mL/s의 유량을 갖는 노즐을 장착한 모델을 사용하였다. 전산 유동가시화 결과로부터, 노즐의 유량을 증가시킬수록 선회류의 발생 정도가 증가하여 구강 내 약물의 잔류 량은 증가하지만, 기관/기관지에 약물 도표는 균일하게 나타났다.
이균범(Kyun Bum Lee),전영선(YoungSun Jeon),김성균(Sung Kyun Kim) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
Since fluid mechanical parameters are heavily affected by the geometry of the flow passage, changes in the anatomical shape of the nasal cavity, due to diseases or surgical treatments, alter the nasal resistance and functions of the nose. There were evidences that nasal secretion and olfaction would be related with the wall shear stress distribution on olfactory region in the nasal cavity. The objective of this research was to observe the changes of airflow pattern in the nasal cavity after middle turbinectomy with varying resection volume, location, and manner(unilateral or bilateral). Airflows inside normal and post-surgery models were investigated numerically by CFD technique. From the comparison of results for pre-and post-surgery models, changes in all evaluated factors increased with the extent of MT resection. The increase in the mucosal wall area with low wall shear stress resulted in the possible loss of the nasal secretion and olfaction function for almost total resection model(M3).
이균범(Gyun-Bum Lee),김성균(Seong-Kyun Kim) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
Drug delivery in human upper airway was studied by the numerical simulation of oral airflow. We created an anatomically accurate upper airway model from CT scan data by using a medical image processing software (Mimics). The upper airway was composed of oral cavity, pharynx, larynx, trachea, and second generations of branches. With this 3D upper airway models, numerical grid (5 parallelepiped layers near the wall and 6 million tetrahedron elements at the inner region surrounded by layers) was generated by ICEM-CFD/FLUENT. The steady inspiratory airflows in that model was solved numerically for the case of flow rate of 250 mL/s with drug-laden spray(Q= 20, 40, 60 mL/s). Optimal parameters for mechanical drug aerosol targeting of predetermined areas was to be computed, for a given representative upper airways. As flow-rate of drug-laden spray increases, the drag spray residue in oral cavity was increased and the distribution of drug spray in trachea and branches became more homogeneous.