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RAW 264.7 세포에서의 미역( Undaria pinnatifida )뿌리 에탄올 추출물의 항염증활성
강보영 ( Bo Kyeong Kang ),안나경 ( Na Kyong Ahn ),최연욱 ( Yeon Uk Choi ),김민지 ( Min Ji Kim ),박시우 ( Si Woo Bark ),박원민 ( Won Min Pak ),김보람 ( Bo Ram Kim ),김꽃봉우리 ( Koth Bong Woo Ri ),안동현 ( Dong Hyun Ahn ) 한국수산과학회 2014 한국수산과학회지 Vol.47 No.6
The anti-inflammatory effects of the ethanol extract ofUndaria pinnatifida root (UPREE) were investigated using the lipopolysaccharide (LPS)-induced inflammatory response in RAW 264.7 cells by measuring the production of nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β, and cell proliferation. We found that NO levels were reduced by 34% at 100 μg/mL. Moreover, the production of IL-6 and TNF-α was suppressed by the UPREE treatment. In particular, the IL-6 production was inhibited by more than 30% at 100 μg/mL UPREE. The proliferation of RAW 264.7 cells was measured by MTT assay, and we found no cytotoxicity in those cells treated with UPREE compared to the control. Our results suggest that UPREE shows promise as a therapeutic anti-inflammatory treatment.