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Direct Thrombus Imaging in Stroke
김종성,박정이,Matthias Nahrendorf,김동억 대한뇌졸중학회 2016 Journal of stroke Vol.18 No.3
There is an emergent need for imaging methods to better triage patients with acute stroke for tissue-plasminogen activator (tPA)-mediated thrombolysis or endovascular clot retrieval by directly visualizing the size and distribution of cerebral thromboemboli. Currently, magnetic resonance (MR) or computed tomography (CT) angiography visualizes the obstruction of blood flow within the vessel lumen rather than the thrombus itself. The present visualization method, which relies on observation of the dense artery sign (the appearance of cerebral thrombi on a non-enhanced CT), suffers from low sensitivity. When translated into the clinical setting, direct thrombus imaging is likely to enable individualized acute stroke therapy by allowing clinicians to detect the thrombus with high sensitivity, assess the size and nature of the thrombus more precisely, serially monitor the therapeutic effects of thrombolysis, and detect post-treatment recurrence. This review is intended to provide recent updates on stroke-related direct thrombus imaging using MR imaging, positron emission tomography, or CT
Kim, Dong-Eog,Kim, Jeong-Yeon,Schellingerhout, Dawid,Ryu, Ju Hee,Lee, Su-Kyoung,Jeon, Sangmin,Lee, Ji Sung,Kim, Jiwon,Jang, Hee Jeong,Park, Jung E.,Kim, Eo Jin,Kwon, Ick Chan,Ahn, Cheol-Hee,Nahrendorf American Heart Association 2017 Stroke Vol. No.
<P>Conclusions-Thromboembolic burden and the efficacy of tPA therapy can be assessed serially, noninvasively, and quantitatively using high-resolution microcomputed tomography and a fibrin-binding nanoparticle imaging agent.</P>