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- 주제어 : Biological indicatior (검색결과 1 건)
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김치년,노재훈,조영봉,문영한 大韓産業醫學會 1992 대한직업환경의학회지 Vol.4 No.2
The objectives of this study are developing the optimal analytic methods for detecting urinary metabolites of carbon disulfide(CS₂) and determining which metabolite is more useful biological indicator for CS₂metabolites, For this experiment, we used synthesized CS₂metabolites, 2-thio-thiazolidine-4-carboxylic acid(TTCA) and thiocarbamide. Those were identified by infrared spectroscopy and nuclear magnetic resonance spectroscopy. The maximum absorbances of TTCA and thiocarbamide were 272 nm and 236 nm respectively. Detection by UV detector was more precise and accurate than that by infrared spectrophotometer. Ethyl acetate extraction method was adopted as precleaning method for HPLC analysis of urinary methabolites. Urinary amount of TTCA and thiocarbamide were measured by HPLC after administration of CS₂(350mg/kg, 700mg/kg) into Sprague-Dawley rats intraperitoneally. Excreted amounts of urinary TTCA and thiocarbamide were increased by the doses of CS₂administration. The urinary amount of TTCA was greater than that of thiocarbamide after administration of both doses of CS₂in rats. These results showed that TTCA seened to be more useful biological indicator for CS₂exposure as ACGIH recommended, however further studies are need to simplyfy analytic methods for measuring the urinary metabolites of CS₂and clarify mechanisms of CS₂metabolism.
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