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Gerbil 전뇌허혈-재관류 모델에서 L-Arginine과 7-Nitroindazole이 뇌손상에 미치는 영향
전영진,김성은,김용재,구혜수 대한응급의학회 2003 대한응급의학회지 Vol.14 No.1
Purpose: This study was performed to determine whether L-Arginine would improve or worsen the neurologic outcome after ischemic brain injury and whether 7-Nitroindazole (7-NI, inhibitors of neuronal nitric oxide (NO) synthase inhibitor) would improve or worsen. Methods: Five (5) groups (N=11 to 14) of anesthetized gerbils were subjected to 10 min of global cerebral ischemia by means of a bilateral carotid artery occlusion. One group (N=11) was the control group. In a second group (N=12), the animals were pretreated with intraperitoneal L-Arginine(300 mg/kg) one hour before ischemic insult. In a third group (N=12), pretreatment with L-Arginine was performed in the same manner and intraperitoneal 7-NI were given at the time of reperfusion and 2 hours after reperfusion. The animals of a fourth group (N=12) were treated with 7-NI in the same manner without any pretreatment with L-Arginine. The animals in the last group (N=14) underwent sham operations. Results: Compared with control group, concomittent treatment with L-Arginine and 7-Ni showed no significant improvement in the neurological cell survival rate. Also, group pretreated with L-Arginine only showed a similar outcome. The group treated with 7-Ni at the time of reperfusion and 2 hours after reperfusion showed a significant improvement in the neurological cell survival rate compared with the control group and the other two experimental groups (p<0.05). Conclusion: In the ischemia-reperfusion injury of global ischemia in gerbils, NO from endothelial NO synthase has no important role in the neurological outcome.
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