YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis

Cho, Hyunsoo,Kim, Jaeryung,Ahn, Ji Hoon,Hong, Young-Kwon,Mä,kinen, Taija,Lim, Dae-Sik,Koh, Gou Young Grune & Stratton 2019 Circulation research Vol.124 No.2

The 8th International Comparison of Absolute Gravimeters 2009: the first Key Comparison (CCM.G-K1) in the field of absolute gravimetry

Jiang, Z,Pá,linká,š,, V,Arias, F E,Liard, J,Merlet, S,Wilmes, H,Vitushkin, L,Robertsson, L,Tisserand, L,Pereira Dos Santos, F,Bodart, Q,Falk, R,Baumann, H,Mizushima, S,Mä,kinen, J Springer-Verlag 2012 METROLOGIA -BERLIN- Vol.49 No.6

<P>The 8th International Comparison of Absolute Gravimeters (ICAG2009) took place at the headquarters of the International Bureau of Weights and Measures (BIPM) from September to October 2009. It was the first ICAG organized as a key comparison in the framework of the CIPM Mutual Recognition Arrangement of the International Committee for Weights and Measures (CIPM MRA) (CIPM 1999). ICAG2009 was composed of a Key Comparison (KC) as defined by the CIPM MRA, organized by the Consultative Committee for Mass and Related Quantities (CCM) and designated as CCM.G-K1. Participating gravimeters and their operators came from national metrology institutes (NMIs) or their designated institutes (DIs) as defined by the CIPM MRA. A Pilot Study (PS) was run in parallel in order to include gravimeters and their operators from other institutes which, while not signatories of the CIPM MRA, nevertheless play important roles in international gravimetry measurements. The aim of the CIPM MRA is to have international acceptance of the measurement capabilities of the participating institutes in various fields of metrology. The results of CCM.G-K1 thus constitute an accurate and consistent gravity reference traceable to the SI (International System of Units), which can be used as the global basis for geodetic, geophysical and metrological observations of gravity. The measurements performed afterwards by the KC participants can be referred to the international metrological reference, i.e. they are SI-traceable.</P><P>The ICAG2009 was complemented by a number of associated measurements: the Relative Gravity Campaign (RGC2009), high-precision levelling and an accurate gravity survey in support of the BIPM watt balance project. The major measurements took place at the BIPM between July and October 2009. Altogether 24 institutes with 22 absolute gravimeters (one of the 22 AGs was ultimately withdrawn) and nine relative gravimeters participated in the ICAG/RGC campaign.</P><P>This paper is focused on the absolute gravity campaign. We review the history of the ICAGs and present the organization, data processing and the final results of the ICAG2009.</P><P>After almost thirty years of hosting eight successive ICAGs, the CIPM decided to transfer the responsibility for piloting the future ICAGs to NMIs, although maintaining a supervisory role through its Consultative Committee for Mass and Related Quantities.</P>

STUDY ON THE CAPABILITY TO MEASURE STAKEHOLDERS’ BRAND EXPERIENCES WITH A CONSUMER-CENTRIC MEASUREMENT FRAMEWORK

Ulla A. Saari,Saku J. Mäkinen 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7

The target of this paper is to introduce a general brand experience measurement scale that can be used to measure brand experiences of the stakeholders of a company. It is proposed that also stakeholders’ brand experiences can be measured with a measurement scale developed for consumer marketing research. In literature, there are various different kinds of individual brand constructs and measurement frameworks that have been developed for tracking consumers’ brand perceptions; however, these models have not been frequently used to measure brandrelated aspects outside consumer-centric situations. The tracking of stakeholders’ brand experiences can help companies to position their brands better in the tightening global competition where also stakeholders have a critical role and can influence the performance of the company (Hult, Mena, Ferrell, & Ferrell, 2011). Brands are experienced via stimuli that can be either controlled by the company, including, for example, advertisements, logos, sales environments, sales packages, and services, or then they are out of their control, for example, brand related information can spread freely on the social media or by word-of-mouth (Brakus, Schmitt, & Zarantonello, 2009; Keller, 2013). Thus, it can be said that the measurement of brand experiences can give valuable information to the company on what is the status and reputation of the brand. However, it is not only the customers or consumers that have brand experiences, also stakeholders encounter brands and the way they experience them on the personal level can have a major impact on how they interact and promote the brand in other contexts. Some B2B marketing theories have brought up the importance of understanding long-term relationships between buyers and sellers, including experiences associated with the relationship (Hadjikhani & LaPlaca, 2013) as well as purchase risks (Brown, Zablah, Bellenger, & Johnston, 2011). Brands are experienced via stimuli that can be either controlled by the company, including, for example, advertisements, logos, sales environments, sales packages, and services, or then they are out of their control, for example, brand related information can spread freely on the social media or by word-of-mouth (Brakus, Schmitt, & Zarantonello, 2009; Keller, 2013). Thus, it can be said that the measurement of brand experiences can give valuable information to the company on what is the status and reputation of the brand. However, it is not only the customers or consumers that have brand experiences, also stakeholders encounter brands and the way they experience them on the personal level can have a major impact on how they interact and promote the brand in other contexts. Some B2B marketing theories have brought up the importance of understanding long-term relationships between buyers and sellers, including experiences associated with the relationship (Hadjikhani & LaPlaca, 2013) as well as purchase risks (Brown, Zablah, Bellenger, & Johnston, 2011). Brand experiences can be measured, for example, with a measurement scale (Brakus et al., 2009) that has been extended with an eco-friendliness dimension (Saari, 2016). This model has been tested with consumers, and this paper argues that the same scale can be useful for monitoring the brand experiences of other stakeholders as well. The extended brand experience scale can be used to monitor whether consumers and stakeholders experience a certain brand to be ecofriendly, and how positively or negatively they are inclined towards the eco-friendliness of the brand experiences. With the raising focus on stakeholders’ important role in solving environmental problems, the role of stakeholder marketing becomes more critical for a company (Homburg, Stierl, & Bornemann, 2013). And in this situation it becomes also more crucial to follow up what are the brand experiences of stakeholders. The stakeholders’ brand experiences can give a strong indication is the company implementing its strategy correctly and are all the essential elements transparently and authentically communicated to the stakeholders, especially with regard to the environmental development activities that are reflected in the eco-friendliness dimension of brand experiences.

On-line High Performance Liquid Chromatography Measurements of Extracellular Metabolites in an Aerobic Batch Yeast (Saccharomyces cerevisiae) Culture

Niina Tohmola,Jouni Ahtinen,Juha-Pekka Pitkänen,Ville Parviainen,Sakari Joenväärä,Mika Hautamäki,Peter Lindroos,Jarno Mäkinen,Risto Renkonen 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.2

We constructed a bioprocess environment enabling automatic sampling from a bioreactor combined with a compact on-line high performance liquid chromatography (HPLC) unit. This setup allowed us to measure extracellular glucose, ethanol, glycerol, and acetate concentrations automatically at 5 min intervals during the cultivation. This environment also provides mechanical measurement of the optical density (OD) of cells and enables us to collect and store (−35℃) samples for further off-line analyses. Among the available devices, the performance of the sampling-analysis unit is by far the best with regard to speed and number of analytes. Both the sampling and analysis phases are easily controlled by software; thus,providing a unique environment to perform various bioprocess activity tasks, whether they would be cell line screening or optimisation of conditions for growth and productivity. Complex research set-ups can be created and continuous automated measurements empower long-term cultivations with a time series. We provide evidence for the applicability of this environment by performing three comparable batch cultivations with Saccharomyces cerevisiae yeast and show that both the on-line sampling and analysis modes produce reliable data for further use in the monitoring and controlling of bioprocesses. On-line data provided new insight into the dynamics of the diauxic shift during aerobic glucose batch cultivation. When cell growth and carbon dioxide production ceased for the first time during the diauxic shift, acetate accumulation and consumption of the remaining glucose below 0.15 g/L continued to occur for 1 h. At the same time, glycerol and ethanol began to be consumed. Samples were also collected during cultivation for later analysis of intracellular metabolites and to collect more valuable information about metabolism.