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이주호,Hlaing Shwe Phyu,caojiafu,핫산 눌하스니,유진욱 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.5
Purpose Nitric oxide (NO) has emerged as a novel agent for the treatment of infected wounds owing to its potent woundhealing effects and antibacterial activity against drug-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). In this study, we developed a NO-releasing ointment composed of S-nitrosoglutathione (GSNO) and polyethylene glycol (PEG) for the treatment of MRSA-infected cutaneous wounds. Methods The GSNO-incorporated PEG ointment (GPO) was successfully prepared by homogeneous dispersion of micronized GSNO in a PEG ointment base. High encapsulation efficiency was achieved (97.25%) via water-free fabrication processing of the GPO, resulting in minimal GSNO hydrolysis. Results When applied to a wound, the wound fluid triggered the degradation of GSNO and NO was released from the GPO for 24 h without an initial burst release. The GPO exhibited potent antibacterial effects against MRSA without cytotoxic effects against L929 cells. An in vivo wound healing experiment using a mouse MRSA-challenged full-thickness wound model revealed that the GPO could facilitate healing of infected wounds. Conclusion Thus, the GPO could be a promising NO-releasing formulation for the treatment of infected cutaneous wounds.
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Recent advances of nanocellulose in drug delivery systems
핫산 눌하스니,Rahman Latifah,Kim So-Hyeon,caojiafu,Arjuna Andi,Lallo Subehan,전병학,유진욱 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.6
Background Nanocellulose, which possesses great physical, chemical, and biological properties, is a natural polymer derived from widely available native cellulose. It has outstanding properties such as high mechanical strength, stiffness, low weight, biocompatibility, and renewability, which are beneficial for the design of advanced drug delivery systems, as either an excipient or a carrier. Area covered This review introduces three types of nanocellulose: cellulose nanocrystals, cellulose nanofibers, and bacterial cellulose. Their physical and chemical properties along with their methods of preparation are also compared. Recent studies of nanocellulose for various drug delivery applications are summarized and discussed. Selected nanocellulose studies with significant findings for oral, ocular, intratumoral, topical, and transdermal delivery are also emphasized. Expert opinion Nanocellulose has potential for drug delivery applications due to its high surface area-to-volume ratio and high polymerization, which provide nanocellulose with a high loading and binding capacity for active pharmaceutical ingredients, enabling the control of the drug release.
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