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Bezoin in Heterocyle Synthesis: Synthesis and Reactions of 2, 3-Diphenyl-4-cyanopyrrole-5-thione
Khalifa, Fathy A.,Zohdi, Hussein F.,Ibrahim, M.K.A.,Ismail, N.A. The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.4
2, 3-diphenyl-4-cyano-pyrrole-5-thione (4) was either by the reaction of benzoin (1) and cyanothioacetamide (3) followed by cyclization using AcOH/sodium acetate or by refluxing a mixture of benzoin (1) and cyanothioacethamide in pyridine to afford directly 4. Several new pyrrole and pyrazole derivatives were synthesised using 4 as synthon. The structure of the newly synthesised derivatives were based on celemental and spectral data studies. Methylation of the SH group in 4 afforded 5. Reaction of 4 with ethyl bromo acetate afforded (6). Treatment of (5) and (6) with hydrazine hydrate afforded the same pyrazole derivative (10) through the intermediate (9). Treatment of 6 with aniline and phenylhydrazine afforded the pyrrole derivatives 8a, b respectively. Treatment of 6 while dill HCI gave 2, 3-diphenyl-4-cyano-pyrrole-5-one (7). Treatment of 6 with $NH_3$/EtOH afforded the amidic derivatives (11) with treatment of 6 $NH_3$/ heat then acidification it gave the carboxylic derivatives (12).
Choi, Sun,Jamshidi, Arash,Seok, Tae Joon,Wu, Ming C.,Zohdi, Tarek I.,Pisano, Albert P. American ChemicalSociety 2012 Langmuir Vol.28 No.6
<P>We report a fast, high-throughput method to create size-tunablemicro/nanoparticle clusters via evaporative assembly in picoliter-scaledroplets of particle suspension. Mediated by gravity force and surfacetension force of a contacting surface, picoliter-scale droplets ofthe suspension are generated from a nanofabricated printing head.Rapid evaporative self-assembly of the particles on a hydrophobicsurface leads to fast clustering of micro/nanoparticles and formsparticle clusters of tunable sizes and controlled spacing. The evaporatingbehavior of the droplet is observed in real-time, and the clusteringcharacteristics of the particles are understood based on the physicsof evaporative-assembly. With this method, multiplex printing of variousparticle clusters with accurate positioning and alignment are demonstrated.Also, size-unifomity of the cluster arrays is thoroughly analyzedby examining the metallic nanoparticle cluster-arrays based on surface-enhancedRaman spectroscopy (SERS).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2012/langd5.2012.28.issue-6/la204362s/production/images/medium/la-2011-04362s_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la204362s'>ACS Electronic Supporting Info</A></P>
Siti Fairus Asahar,Khasnur Abd Malek,Wan Najwa Wan Mohd Zohdi,Alan Basil Peter 대한가정의학회 2020 Korean Journal of Family Medicine Vol.41 No.1
We present the case of a 14-year-old Malay girl with an ependymoma of the conus medullaris who presented to multiple general practitioner clinics with a 24-month history of chronic low back pain. The pain was symptomatically managed as a simple musculoskeletal pain and sciatica. Further imaging to aid diagnosis was delayed until the appearance of severe pain with neurological deficits. Magnetic resonance imaging revealed an enhancing spinal mass at L1 through L3, and histopathological investigations confirmed the grade II ependymoma according to the World Health Organization classification. She underwent gross resection of the tumor. After the surgery, she developed neurogenic urinary bladder and bowel, which required intermittent self-catheterization, intermittent enema use, and intensive physical therapy.