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- 저자 : Zhongcheng Xin (검색결과 5 건)
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Optical Model of a Human Eye’s Crystalline Lens based on a Three-layer Liquid Lens
Meimei Kong,Xin Chen,Yang Yuan,Rui Zhao,Tao Chen,Zhongcheng Liang 한국광학회 2019 Current Optics and Photonics Vol.3 No.2
Based on liquid-lens technology and our previous findings on the optical model of the Chinese eye, the liquid lens is applied in the research of the crystalline-lens optical model. Theoretical models of three-layer liquid lenses are built with COMSOL software, and the effect of voltage on the shape of the interface between two liquids is analyzed. By polynomial fitting, different equations describing the interface shape are set up under different voltages. Finally, the optical system of the human eye with a three-layer liquid lens is built and analyzed with Zemax optical design software, and moreover the optical system models of emmetropia, myopia, and hyperopia are presented. This method to build a model of the human eye with a variable-focus liquid lens can provide a novel idea for more practical human-eye models for clinical regulation and control in the future.
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ELECTRIC-HYDRAULIC COMPOUND CONTROL ANTI-LOCK BRAKING SYSTEM
Feng Yang,Xin Chen,Dong Guo,Mingmao Hu,Ziwen Liao,Zhongcheng Fu,Qingshan Gong 한국자동차공학회 2022 International journal of automotive technology Vol.23 No.6
An anti-lock control strategy for electric-hydraulic compound braking is proposed to improve the emergency braking safety of a hub motor electric vehicle. Based on the half-vehicle braking longitudinal dynamics model, the optimal control is solved to obtain the total braking torque corresponding to each wheel. A fuzzy algorithm is used to determine the proportion coefficient of the motor based on the battery state of charge coefficient (SOC) and the motor speed constraints on the motor braking, and the total braking torque is distributed. The hydraulic and motor braking torques obtained from the allocation are input as reference values to the electric-hydraulic compound braking system, and the output braking torque is fed back into the CarSim vehicle model. The proposed electric-hydraulic compound ABS control strategy is also validated in the co-simulation of CarSim and MATLAB/Simulink on high, medium and low adhesion road surfaces.
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Huixi Li,Zhichao Zhang,Jing Peng,Zhongcheng Xin,Meng Li,Bicheng Yang,Dong Fang,Yuan Tang,Yinglu Guo 대한비뇨의학회 2019 Investigative and Clinical Urology Vol.60 No.5
Purpose: To investigate whether treatment with low-energy shock wave (LESW) alleviates pain and bladder dysfunction in a mouse model of uroplakin 3A (UPK3A)-induced interstitial cystitis/painful bladder syndrome (IC/PBS). Materials and Methods: Forty female BALB/c mice were divided into four groups (n=10/group): Sham, Sham+LESW, UPK3A, and UPK3A+LESW. At 6 weeks of age, mice were injected with an emulsion containing water and complete Freund's adjuvant with (UPK3A and UPK3A+LESW groups) or without (Sham and Sham+LESW groups) 200 µg of UPK3A. At 10 weeks, mice received a second dose of Freund's adjuvant to booster immunization. At 12 weeks, mice underwent pain assessment and a frequency volume chart (FVC) test as the pretreatment assessment. LESW treatment and pain assessment were conducted from 13 to 15 weeks. One week after the final treatment, pain assessment and the FVC were conducted again as the post-treatment assessment. Mice were euthanized and sacrificed at 17 weeks. Results: The presence of tactile allodynia and bladder dysfunction was significant in the UPK3A-injected mice. LESW raised the pain threshold and improved bladder function with decreased urinary frequency and increased mean urine output. Expression and secretion of local and systemic inflammatory markers, including tumor necrosis factor-α (TNF-α) and nerve growth factor (NGF), increased after UPK3A immunization. These markers were significantly decreased after LESW treatment (p<0.05). Conclusions: LESW treatment attenuated pain and bladder dysfunction in a UPK3A-induced model of IC/PBS. Local and systemic inflammation was partially controlled, with a reduced number of infiltrated inflammatory cells and reduced levels of TNF-α and NGF.
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Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 via miR-411-5p
Pan Jiancheng,Liu Zihao,Yang Zhizhao,Liang Enli,Fang Cheng,Zhang Dingrong,Zhou Xiaodong,Niu Yuanjie,Xin Zhongcheng,Chen Yegang,Cai Qiliang 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.1
Purpose: As the mechanism of interaction between circular RNAs (circRNAs) and microRNAs (miRNAs) in regulating the development of prostate cancer (PCa) is not clear, this study focuses on investigating these effects. Materials and Methods: Sample tissues were collected from the PCa of patients, and microarray analysis of human circRNAs was conducted. The expression of circ_0001686, hsa_miR-411-5p (miR-411-5p) were also detected by qRT-PCR. Circ_0001686 and miR-411-5p mimics were transfected into the PCa cell lines (CWR22RV1and LNCaP) and MTT, colony formation, Transwell, and scratch wound assays were used to analyze the biological behaviors of PCa cells. Si-circ_0001686 and ASO-miR-411-5p were used as negative controls, and dual-luciferase reporter assays were performed to verify the interactions among circ_0001686, miR-411-5p, and SMAD3/TGFBR2. The levels of SMAD3 and TGFBR2 in different treated PCa cells were measured by western blot, and in vivo experiments in a nude mouse model were carried out to strengthen the in vitro findings of miR-411-5p. Results: The expression of circ_0001686 was up-regulated, while the expression of miR-411-5p was down-regulated in PCa cells. Moreover, circ_0001686 promoted cell proliferation, migration, and invasion. Molecular mechanism exploration revealed that circ_0001686 could reduce miR-411-5p, affecting the downstream target genes of SMAD3 and TGFBR2. In vitro and in vivo studies verified that miR-411-5p inhibits PCa progression. Conclusions: Circ_0001686 can reduce miR-411-5p to increase the expression of SMAD3/TGFBR2, which consequently promotes the proliferation, invasion, and migration of PCa cells.
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Low-Intensity Shock Wave Therapy and Its Application to Erectile Dysfunction
Hongen Lei,Jing Liu,Huixi Li,Lin Wang,Yongde Xu,Wenjie Tian,Guiting Lin,Zhongcheng Xin 대한남성과학회 2013 The World Journal of Men's Health Vol.31 No.3
Although phosphodiesterase type 5 inhibitors (PDE5Is) are a revolution in the treatment of erectile dysfunction (ED) and have been marketed since 1998, they cannot restore pathological changes in the penis. Low-energy shock wave therapy (LESWT) has been developed for treating ED, and clinical studies have shown that LESWT has the potential to affect PDE5I non-responders with ED with few adverse effects. Animal studies have shown that LESWT significantly improves penile hemodynamics and restores pathological changes in the penis of diabetic ED animal models. Although the mechanisms remain to be investigated, recent studies have reported that LESWT could partially restore corpus cavernosum fibromuscular pathological changes, endothelial dysfunction, and peripheral neuropathy. LESWT could be a novel modality for treating ED, and particularly PDE5I non-responders with organic ED, in the near future. However, further extensive evidence-based basic and clinical studies are needed. This review intends to summarize the scientific background underlying the effect of LESWT on ED.
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