A Coordinated Ciphertext Policy Attribute-based PHR Access Control with User Accountability

( Guofeng Lin ),( Lirong You ),( Bing Hu ),( Hanshu Hong ),( Zhixin Sun ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.4

The personal health record (PHR) system is a promising application that provides precise information and customized services for health care. To flexibly protect sensitive data, attribute-based encryption has been widely applied for PHR access control. However, escrow, exposure and abuse of private keys still hinder its practical application in the PHR system. In this paper, we propose a coordinated ciphertext policy attribute-based access control with user accountability (CCP-ABAC-UA) for the PHR system. Its coordinated mechanism not only effectively prevents the escrow and exposure of private keys but also accurately detects whether key abuse is taking place and identifies the traitor. We claim that CCP-ABAC-UA is a user-side lightweight scheme. Especially for PHR receivers, no bilinear pairing computation is needed to access health records, so the practical mobile PHR system can be realized. By introducing a novel provably secure construction, we prove that it is secure against selectively chosen plaintext attacks. The analysis indicates that CCP-ABAC-UA achieves better performance in terms of security and user-side computational efficiency for a PHR system.

Role of IFNLR1 gene in PRRSV infection of PAM cells

Ming Qin,Wei Chen,Zhixin Lin,Lixue Wang,Lixia Ma,Jinhong Geng,Yu Zhang,Jing Zhao,Yong-Qing Zeng 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.3

Background: Interferon lambda receptor 1 (IFNLR1) is a type II cytokine receptor that clings to interleukins IL-28A, IL29B, and IL-29 referred to as type III IFNs (IFN-λs). IFN-λs act through the JAK-STAT signaling pathway to exert antiviral effects related to preventing and curing an infection. Although the immune function of IFN-λs in virus invasion has been described, the molecular mechanism of IFNLR1 in that process is unclear. Objectives: The purpose of this study was to elucidate the role of IFNLR1 in the pathogenesis and treatment of porcine reproductive and respiratory syndrome virus (PRRSV). Methods: The effects of IFNLR1 on the proliferation of porcine alveolar macrophages (PAMs) during PRRSV infection were investigated using interference and overexpression methods. Results: In this study, the expressions of the IFNLR1 gene in the liver, large intestine, small intestine, kidney, and lung tissues of Dapulian pigs were significantly higher than those in Landrace pigs. It was determined that porcine IFNLR1 overexpression suppresses PRRSV replication. The qRT-PCR results revealed that overexpression of IFNLR1 upregulated antiviral and IFN-stimulated genes. IFNLR1 overexpression inhibits the proliferation of PAMs and upregulation of p-STAT1. By contrast, knockdown of IFNLR1 expression promotes PAMs proliferation. The G0/G1 phase proportion in IFNLR1-overexpressing cells increased, and the opposite change was observed in IFNLR1-underexpressing cells. After inhibition of the JAK/STAT signaling pathway, the G2/M phase proportion in the IFNLR1-overexpressing cells showed a significant increasing trend. In conclusion, overexpression of IFNLR1 induces activation of the JAK/STAT pathway, thereby inhibiting the proliferation of PAMs infected with PRRSV. Conclusion: Expression of the IFNLR1 gene has an important regulatory role in PRRSV-infected PAMs, indicating it has potential as a molecular target in developing a new strategy for the treatment of PRRSV.

A Secure and Efficient Cloud Resource Allocation Scheme with Trust Evaluation Mechanism Based on Combinatorial Double Auction

( Yunhao Xia ),( Hanshu Hong ),( Guofeng Lin ),( Zhixin Sun ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.9

Cloud computing is a new service to provide dynamic, scalable virtual resource services via the Internet. Cloud market is available to multiple cloud computing resource providers and users communicate with each other and participate in market transactions. However, since cloud computing is facing with more and more security issues, how to complete the allocation process effectively and securely become a problem urgently to be solved. In this paper, we firstly analyze the cloud resource allocation problem and propose a mathematic model based on combinatorial double auction. Secondly, we introduce a trust evaluation mechanism into our model and combine genetic algorithm with simulated annealing algorithm to increase the efficiency and security of cloud service. Finally, by doing the overall simulation, we prove that our model is highly effective in the allocation of cloud resources.

An improved time-domain approach for the spectra-compatible seismic motion generation considering intrinsic non-stationary features

Cheng Feng,Li Jianbo,Ding Zhixin,Lin Gao 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.3

The dynamic structural responses are sensitive to the time-frequency content of seismic waves, and seismic input motions in time-history analysis are usually required to be compatible with design response spectra according to nuclear codes. In order to generate spectra-compatible input motions while maintaining the intrinsic non-stationarity of seismic waves, an improved time-domain approach is proposed in this paper. To maintain the nonstationary characteristics of the given seismic waves, a new time-frequency envelope function is constructed using the Hilbert amplitude spectrum. Based on the intrinsic mode functions (IMFs) obtained from given seismic waves through variational mode decomposition, a new corrective time history is constructed to locally modify the given seismic waves. The proposed corrective time history and time-frequency envelope function are unique for each earthquake records as they are extracted from the given seismic waves. In addition, a dimension reduction iterative technique is presented herein to simultaneously superimpose corrective time histories of all the damping ratios at a specific frequency in the time domain according to optimal weights, which are found by the genetic algorithm (GA). Examples are presented to show the capability of the proposed approach in generating spectra-compatible time histories, especially in maintaining the nonstationary characteristics of seismic records. And numerical results reveal that the modified time histories generated by the proposed method can obtain similar dynamic behaviors of AP1000 nuclear power plant with the natural seismic records. Thus, the proposed method can be efficiently used in the design practices

Involvement of Orai1 in tunicamycin-induced endothelial dysfunction

Hui Yang,Yumei Xue,Sujuan Kuang,Mengzhen Zhang,Jinghui Chen,Lin Liu,Zhixin Shan,Qiuxiong Lin,Xiaohong Li,Min Yang,Hui Zhou,Fang Rao,Chunyu Deng 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.2

Endoplasmic reticulum (ER) stress is mediated by disturbance of Ca2+ homeostasis. The store-operated calcium (SOC) channel is the primary Ca2+ channel in non-excitable cells, but its participation in agent-induced ER stress is not clear. In this study, the effects of tunicamycin on Ca2+ influx in human umbilical vein endothelial cells (HUVECs) were observed with the fluorescent probe Fluo-4 AM. The effect of tunicamycin on the expression of the unfolded protein response (UPR)-related proteins BiP and CHOP was assayed by western blotting with or without inhibition of Orai1. Tunicamycin induced endothelial dysfunction by activating ER stress. Orai1 expression and the influx of extracellular Ca2+ in HUVECs were both upregulated during ER stress. The SOC channel inhibitor SKF96365 reversed tunicamycin-induced endothelial cell dysfunction by inhibiting ER stress. Regulation of tunicamycin-induced ER stress by Orai1 indicates that modification of Orai1 activity may have therapeutic value for conditions with ER stress-induced endothelial dysfunction.

Involvement of Orai1 in tunicamycin-induced endothelial dysfunction

Yang, Hui,Xue, Yumei,Kuang, Sujuan,Zhang, Mengzhen,Chen, Jinghui,Liu, Lin,Shan, Zhixin,Lin, Qiuxiong,Li, Xiaohong,Yang, Min,Zhou, Hui,Rao, Fang,Deng, Chunyu The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.2

Endoplasmic reticulum (ER) stress is mediated by disturbance of $Ca^{2+}$ homeostasis. The store-operated calcium (SOC) channel is the primary $Ca^{2+}$ channel in non-excitable cells, but its participation in agent-induced ER stress is not clear. In this study, the effects of tunicamycin on $Ca^{2+}$ influx in human umbilical vein endothelial cells (HUVECs) were observed with the fluorescent probe Fluo-4 AM. The effect of tunicamycin on the expression of the unfolded protein response (UPR)-related proteins BiP and CHOP was assayed by western blotting with or without inhibition of Orai1. Tunicamycin induced endothelial dysfunction by activating ER stress. Orai1 expression and the influx of extracellular $Ca^{2+}$ in HUVECs were both upregulated during ER stress. The SOC channel inhibitor SKF96365 reversed tunicamycin-induced endothelial cell dysfunction by inhibiting ER stress. Regulation of tunicamycin-induced ER stress by Orai1 indicates that modification of Orai1 activity may have therapeutic value for conditions with ER stress-induced endothelial dysfunction.