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RISS 인기검색어
- 검색키워드
- 저자 : Zhentao Guo (검색결과 4 건)
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Zhentao Guo,Qianxue Chen,Baohui Liu,Daofeng Tian,Shenqi Zhang,Mingchang Li 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.5
Purpose: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a tumor suppressor gene and may be related to tumor drug resistance. In this study, we explored whether LRIG1 protein expression can improve the chemosensitivity of glioma cells and what was its mechanism. Materials and Methods: We collected 93 cases of glioma tissues and detected the expression of LRIG1 and BCL-2. We constructed a multidrugresistance cell line U251/multidrug resistance (MDR) and examined the change of LRIG1 and BCL-2 at mRNA and protein expression levels. LRIG1 expressionwas upregulated in U251/MDR cells and we detected the change of multidrug resistance. Meanwhile, we changed the expression of LRIG1 and BCL-2 and explored the relationship between LRIG1 and BCL-2. Finally, we also explored the relationship between LRIG1 and RTKs. Results: LRIG1 was negatively correlated with BCL-2 expression in glioma tissue and U251/MDR cells, and upregulation of LRIG1 can enhance chemosensitivity and inhibit BCL-2 expression. Furthermore, LRIG1 was negatively correlated with RTKs in U251/MDR cells. Conclusion: These results demonstrated that LRIG1 can improvechemosensitivity by modulating BCL-2 expression and RTK signaling in glioma cells.
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Zhentao Li,Jie Dong,Jian Huang,Tao Guo,Shihua Wang,Xin Zhao,Qinghua Zhang 한국고분자학회 2020 Macromolecular Research Vol.28 No.1
In this work, two sets of high performance polyimide (PI) fibers fabricated by a more environmentally-friendly and highly efficient “reaction-spinning” method were firstly reported. The relationship between the spinning rate, chemical structure and the imidization degree of the PI precursor fibers were investigated, and the results indicated a moderate low spinning speed and relatively flexible molecular chains are both favorable for the partial imidization reaction in the spinning process. 2D WAXD results demonstrate that the rigid PDA-based PI fibers possess a higher alignment of polymer chains along the fiber axis during the spinning compared to the flexible ODA-based PIs, resulting in enhanced mechanical properties, with the tensile strength of 1.2-2.8 GPa and modulus of 53.6-111.2 GPa, respectively. Meanwhile, ODA sets of PI fibers exhibit a higher loop strength and knot strength than the commercial Aramid and PBO fibers. The process used in this study has a significant potential for realizing industrial level production of high strength and high modulus PI fibers.
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Adaptive Subpixel Edge Detection for Locating the Center of Nut Screw Hole
Rui Yang,Hanming Guo,Zhentao Chen,Jiuai Sun 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.8
An accurate and fast machine vision-based method for locating the center of disk nuts is of tremendous significant for safe installation and maintaining service life of glass curtain wall. However, current manual or image processing approaches suffer from the problems of inaccurate or time consuming. Based on the intensity distribution model around the edge of screw holes within actual captured images, a Gaussian weighted adaptive threshold method is proposed to replace traditional Otsu threshold algorithm to identify the edge of screw holes in a level of subpixel. The identified edge points are used to fi t the center of hole via a least square estimation algorithm. Both simulation and real object evaluation have shown that the proposed algorithm has higher accuracy in locating the center of the screw holes and demonstrated with good tolerance to noise and faster processing speed comparing to that of the traditional algorithm.
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Glioma Stem Cell-Targeted Dendritic Cells as a Tumor Vaccine Against Malignant Glioma
Baowei Ji,Qianxue Chen,Baohui Liu,Liquan Wu,Daofeng Tian,Zhentao Guo,Wei Yi 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.1
Purpose: Cancer stem cells have recently been thought to be closely related to tumor development and reoccurrence. It may be a promising way to cure malignant glioma by using glioma stem cell-targeted dendritic cells as a tumor vaccine. In this study, we explored whether pulsing dendritic cells with antigens of glioma stem cells was a potent way to induce specific cytotoxic T lymphocytes and anti-tumor immunity. Materials and Methods: Cancer stem cells were cultured from glioma cell line U251. Lysate of glioma stem cells was obtained by the repeated freezing and thawing method. Dendritic cells (DCs) were induced and cultured from the murine bone marrow cells, the biological characteristics were detected by electron microscope and flow cytometry. The DC vaccine was obtained by mixing DCs with lysate of glioma stem cells. The DC vaccine was charactirizated through the mixed lymphocyte responses and cell killing experiment in vitro. Level of interferon-γ (IFN-γ) in the supernatant was checked by ELISA. Results: After stimulation of lysate of glioma stem cell, expression of surface molecules of DC was up-regulated, including CD80, CD86, CD11C and MHC-II. DCs pulsed with lysate of glioma stem cells were more effective than the control group in stimulating original glioma cells-specific cytotoxic T lymphocytes responses, killing glioma cells and boosting the secretion of IFN-γ in vitro. Conclusion: The results demonstrated DCs loaded with antigens derived from glioma stem cells can effectively stimulate naive T cells to form specific cytotoxic T cells, kill glioma cells cultured in vitro.
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