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The Biosynthesis Pathway of Swainsonine, a New Anticancer Drug from Three Endophytic Fungi
( Zhenhui Ren ),( Runjie Song ),( Shuai Wang ),( Haiyun Quan ),( Lin Yang Lu ),( Sun Baoyu Zhao ),( Hao Lu ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.11
Swainsonine (SW) is the principal toxic ingredient of locoweed plants that causes locoism characterized by a disorder of the nervous system. It has also received widespread attention in the medical field for its beneficial anticancer and antitumor activities. Endophytic fungi, Alternaria sect. Undifilum oxytropis isolated from locoweeds, the plant pathogen Slafractonia leguminicola, and the insect pathogen Metarhizium anisopliae, produce swainsonine. Acquired SW by biofermentation has a certain foreground and research value. This paper mainly summarizes the local and foreign literature published thus far on the swainsonine biosynthesis pathway, and speculates on the possible regulatory enzymes involved in the synthesis pathway within these three fungi in order to provide a new reference for research on swainsonine biosynthesis by endophytic fungi.
Yulan Gao,Xiangchen Fang,Zhenmin Cheng,Liming Xu,Zhenhui Lu,Shanda Wang 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.26 No.-
An ex-situ presulfurization technology for transforming the metal oxides of hydrotreating catalyst to the corresponding metal oxy-sulfides was developed, involving pre-dispersion of an organo-nitrogen substance onto catalyst and a subsequent multi-step heat treatment. The inherence of exothermic effect involved in the ex situ pre-sulfurized catalyst fabrication and activation, and particularly the relationship between the exothermic effect and the surface property of catalyst were investigated. The results indicated that both the preparation parameters and the operating conditions can have effects on the exothermic behavior and surface state of the catalyst. The information obtained in the current study is useful for optimizing the EPRES process, essential for hydrotreating catalyst and its application.