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Antimicrobial curcumin nanoparticles downregulate joint inflammation and improve osteoarthritis
Zhengqiu Lin,Shicui Jiang,Xiuzhi Ye,Minghai Dai,Guojing Yang,Liangle Liu 한국고분자학회 2023 Macromolecular Research Vol.31 No.12
Osteoarthritis (OA) is characterized by degenerative lesions in articular cartilage and becomes increasingly difficult to treat as the inflammatory response progresses and damage to joint cartilage occurs. Therefore, novel therapeutic options are required. In this study, curcumin (Cur) nanoparticles (Cur@Zn&TA) were prepared using a metal–phenol network based on Zn2+ ions and tannic acid (TA). The poor bioavailability of Cur, caused by low and rapid metabolism, was resolved by metal–phenol network wrapping, thus prolonging the time of action of the drug. This composite nanostructure has several biological effects, including anti-inflammatory, antibacterial, and chondroprotective, which are ideal for treating OA. Animal tests indicated that Cur@Zn&TA nanoparticles can be directly injected into the joint cavity to regulate the inflammatory response of OA, effectively promoting OA repair and preventing bacterial infections to achieve rapid and long-term treatment of OA.
Zhengqiu Li,Lin Ye,Xiaowen Zhao,Phil Coates,Fin Caton-Rose,Michael Martyn 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.52 No.-
Highly oriented long-chain-branched poly(lactic acid) (LCB-PLA)film was fabricated through biaxial hotstretching in solid state. Compared with neat PLA, more homogeneousfilm with higher draw ratio can beobtained for LCB-PLA. With increasing draw ratio, the long period, lamellae thickness and grain size ofLCB-PLA decreased, while the crystallinity increased. For LCB-PLA with draw ratio of 6*6, the tensilestrength and elongation at break can reach up to 208 6 MPa and 85% respectively. After drawing, theincreasing content ofCH3 and C¼O group on the surface of LCB-PLAfilm was beneficial for celladhesion and growth on it.