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( Yunyun Jiang ),( Fazheng Ren ),( Songling Liu ),( Liang Zhao ),( Huiyuan Guo ),( Caiyun Hou ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.3
Acid stress can affect the viability of probiotics, especially Bifidobacterium. This study aimed to improve the acid tolerance of Bifidobacterium longum BBMN68 using adaptive evolution. The stress response, and genomic differences of the parental strain and the variant strain were compared by acid stress. The highest acid-resistant mutant strain (BBMN68m) was isolated from more than 100 asexual lines, which were adaptive to the acid stress for 10th, 20th, 30th, 40th, and 50th repeats, respectively. The variant strain showed a significant increase in acid tolerance under conditions of pH 2.5 for 2 h (from 7.92 to 4.44 log CFU/ml) compared with the wildtype strain (WT, from 7.87 to 0 log CFU/ml). The surface of the variant strain was also smoother. Comparative whole-genome analysis showed that the galactosyl transferase D gene (cpsD, bbmn68_1012), a key gene involved in exopolysaccharide (EPS) synthesis, was altered by two nucleotides in the mutant, causing alteration in amino acids, pI (from 8.94 to 9.19), and predicted protein structure. Meanwhile, cpsD expression and EPS production were also reduced in the variant strain (p < 0.05) compared with WT, and the exogenous WT-EPS in the variant strain reduced its acid-resistant ability. These results suggested EPS was related to acid responses of BBMN68.
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A Feasibility Research on the Mechanism of Cold Chain Business in Deppon Logistics
Yanni Li,Yunyun Xu,Baichao Gong,Haopeng Sun,Fuguang Zhao 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.3
Cold chain distribution is always well-known as the “Mount Everest” in international logistics industry, while the rapid development in recent years of domestic meat, frozen food, cold drinks industry and dairy industry brought a leapfrog growth of cold chain logistics, which respectively stimulated the need for logistics outsourcing service from Third Party Logistics. Those companies demanding for exploiting cold chain business on one hand requires a complete set of refrigerated logistics chains, on the other hand also requires enterprises to establish a good and professional transport system with refrigerated operation equipment, which are precisely the weakness of manufacturing enterprises. Thus, outsourcing of cold chain logistics to a third party is the best choice for companies to focus on its core business. By analyzing the bulletins of International Cold Chain Logistics Summits, this paper shows the problems of cold chain industry in China and points out the potentials for its future development. It further analyzes the feasibility of launching cold chain business of Deppon Logistics. The purpose is to offer some suggestions to work out the barriers and set up a modern operation system under the big data age in Deppon.
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LI Kunpeng,LIU Wei,LI Qunzhan,ZHAO Yunyun,HE Zhixin,SHI Haiou,JIN Shoujie,CHEN Guangzan 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
The rational use of regenerative braking energy for urban rail transit trains directly affects the voltage safety of the traction power supply system and the electric braking function of the train. It is also of great significance for the implementation of train traction energy saving. This paper proposes a scheme of train regenerative braking ground absorbing device based on super-capacitor energy storage. It adopts multiple modular Buck/Boost DC conversion topology to realize bidirectional control of electric energy and stabilize the secondary utilization of traction network voltage and regenerative electric energy. According to the scheme of this paper, the energy storage device was developed and verified in the engineering of the Guangzhou Line 6 main line traction substation. The test indicators have met the design expectations.
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Gastric Cancer Stem Cells: Mechanisms and Therapeutic Approaches
Yan Fu,Peizhun Du,Jing Zhao,Cheng’en Hu,Yunyun Qin,Guangjian Huang 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.10
Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. GC stem-like cells (GCSCs), with unlimitedself-renewal, differentiation, and tumor-regenerating capacities, contribute significantly to the refractory features of GC and havegained increasing attention for their role in GC drug resistance, relapse, and metastasis. Therapies targeting GCSCs seem to beone of the most promising methods to improve the outcomes of GC patients. Extensive investigations have attempted to outlinethe regulatory mechanisms in GCSCs and to develop GCSCs-targeting therapies with which to diminish GC drug resistance, metastasisand relapse. To the best of our knowledge, there is a lack of reviews summarizing these studies. In this review, we systematicallyrecapitulated findings regarding the regulatory mechanisms of GCSCs, as well as therapies that target GCSCs, hoping tosupport the development of prognostic biomarkers and GCSCs-targeting anticancer therapies in GC.
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