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( Dong Jin Park ),( Shin Seok Lee ),( Ji Hyoun Kang ),( Jung Ho Choi ),( Yi Rang Yim ),( Jeong Won Lee ),( Kyung Eun Lee ),( Li Hui Wen ),( Tae Jong Kim ),( Yong Wook Park ),( Yukitoshi Takahashi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The high concordance of systemic lupus erythematosus (SLE) with fi bromyalgia (FM) suggests common underlying mechanisms related to pain and distress in both patient groups. This study was aimed to evaluate roles of NMDAR antibodies in development of FM in SLE patients Methods: Sera from 104 SLE patients, 112 FM patients, and 110 healthy controls were analyzed to detect titers of antibodies to N-terminus of 2B subunit of NMDAR (GluN2B). Clinical, laboratory data and concomitant diseases were found by reviewingthe patient charts. We underwent clinical examination and neuropsychiatric evaluation, and interviewed SLE patients using a structured questionnaire that included FM and neuropsychiatric symptoms. Results: 18 patients (17. 3 %) of total 104 SLE patients were revealed having FM. The titer of anti-GluN2B antibodies was signifi cantly higher in SLE patients than FM patients and healthy controls (P < 0. 001). In SLE patients, patients with concomitant FM showed higher titers of anti-GluN2B antibodies (P < 0. 05). The titers of anti-GluN2B antibodies were correlated with tender point count (Spearman`s rho = 0. 238, P = 0. 016) and widespread pain index (Spearman`s rho = 0. 276, P = 0. 005), but not with other symptom scales. Anti-GluN2B antibody-positive SLE patients were more likely to have NPSLE and concomitant FM (P < 0. 05). In multivariate analysis, Anti-GluN2B antibody was independent predictor of concomitant FM and NPSLE. Conclusions: This is the fi rst study to present that antibodies to NMDAR may be associated with pathogenesis of FM in SLE patients.