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Gao Linglin,Zhu Hao,Chen Yun,Yang Yuhui 한국미생물학회 2021 The journal of microbiology Vol.59 No.12
Cefquinome (CEQ) is a novel β-lactam antibiotic that exhibits excellent antibacterial activity against Staphylococcus aureus. However, the bacterial protein targets of CEQ are unclear. To evaluate the relationship between the pharmacokinetic/ pharmacodynamic (PK/PD) parameters of CEQ and strains with varying degrees of resistance and to elucidate bacterial protein responses to CEQ treatment, label-free quantitative proteomics analysis was conducted. The sensitive S. aureus ATCC6538 and the resistant 2MIC and 8MIC were tested for differentially expressed proteins. An in vitro model was treated with different concentrations of CEQ (3, 5, or 10 μg/ml) with different terminal half-lives (2.5 or 5 h) at different intervals (12 or 24 h). Differentially expressed proteins were evaluated using Gene Ontology analysis followed by KEGG pathway enrichment analysis and STRING network analysis. RT-qPCR was performed to validate the differentially expressed proteins at the molecular level. The results showed that the degree of resistance increased in a cumulative manner and increased gradually with the extension of administration time. The resistant strain would not have appeared in the model only if %T > mutant prevention concentration ≥ 50%. The expression of 45 proteins significantly changed following CEQ treatment, among which 42 proteins were obviously upregulated and 3 were downregulated. GO analysis revealed that the differentially expressed proteins were mainly present on cells and the cell membrane, participated in metabolic and intracellular processes, and had catalytic and binding activities. The RPSO, SDHB, CITZ, ADK, and SAOUHSC 00113 genes in S. aureus may play important roles in the development of resistance to CEQ. These results provided important reference candidate proteins as targets for overcoming S. aureus resistance to CEQ.
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Guojin Gong,Rigetu Zhao,Yuhui Zhu,Jinfeng Yu,Bin Wei,Yan Xu,Zhaoxun Cui,Guoying Liang 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.5
This study was designed to evaluate the gastroprotective activity of cirsilineol in hydrochloric acid (HCl)/ethanol-induced gastric ulcer model. Cirsilineol was administered at the doses of 20 and 40 mg/kg in HCl/ethanol-induced rats. The gastroprotective ability was verified by determining the ulcer score, total acidity, hemoglobin, inflammatory cytokines, lipid peroxides, and enzymatic antioxidants superoxide dismutase (SOD) and catalase (CAT) in gastric tissue and serum biochemical analysis. The results showed a favorable increase in the hemoglobin level, antioxidant enzymes (SOD and CAT), restored electrochemical balance (carbon dioxide & anion gap) while a noticeable decrease in ulcer index, total acidity, lipid peroxides, inflammatory cytokines (interleukin-1 beta [IL-1β], IL-6, and tumor necrosis factor alpha) in rats treated with the cirsilineol. The serum biochemical analysis on liver markers (alkaline phosphatases, alanine aminotransferase, and aspartate aminotransferase), kidney markers (urea, creatinine, albumin, globulin, total protein), and lipid profile (triglyceride, high-density lipoprotein, total cholesterol) were attenuated by cirsilineol treatment in rats. Histopathology showed enhanced gastric protection and preserved the integrity of gastric mucosa upon cirsilineol administration. These results ultimately suggest that cirsilineol has gastroprotective effects that prevent the development of gastric ulcer.
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Dynamic Event-triggered Approximate Optimal Control Strategy for Nonlinear Systems
Songsong Cheng,Mingjian Zhu,Yuhui Fu,Xiaohan Fang,Yuan Fan 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.5
This work proposes a novel dynamic event-triggered approximate optimal control strategy for nonlinear continuous-time systems. By employing the dynamic event-triggered control scheme, the purposes of maintaining system stability, approximatly minimizing the cost function, and saving communication as well as computation resources can be achieved simultaneously. Firstly, to obtain the solution of the optimal control problem, we propose the Hamiltonian-Jacobian-Bellman (HJB) equation. A critic network is involved to approximate the optimal discounted cost function. A weight matrix update scheme using gradient descent method is designed to realize the weight calculation of the neural network. Secondly, a dynamic event-triggered condition has been presented to derive a near optimal event-triggered controller, which is more efficient in resource utilization than that of existing results. By using the Lyapunov method, it is proven that the states in the closed-loop system are uniformly ultimately bounded. Finally, numerical results and some comparison with the static ETM and time-triggered systems have been provided to illustrate the effectiveness of the proposed dynamic event-triggered mechanisms (ETM).
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A design method for multi-degree-of-freedom aeroelastic model of super tall buildings
Lei Wang,Yong-jie Zhu,Ze-kang Wang,Yuhui Fan 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.32 No.3
Wind tunnel test models for super tall buildings mainly include synchronized pressure models, high-frequency force balance models, forced vibration models and aeroelastic models. Aeroelastic models, especially MDOF aeroelastic models, are relatively accurate, and designing MDOF model is an important step in aero-model wind tunnel tests. In this paper, the authors propose a simple and accurate design method for MDOF model. The purpose of this paper is to make it easier to design MDOF models without unnecessary experimentation, which is of great significance for the use of the aero-model for tall buildings.
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