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Yu, J.,Wang, L.,Lai, X.,Pei, S.,Zhuang, Z.,Meng, L.,Huang, Y.,Li, Q.,Lu, W.,Byun, J.H.,Oh, Y.,Yan, Y.,Chou, T.W. Pergamon Press ; Elsevier Science Ltd 2015 Carbon Vol.94 No.-
In spite of the recent rapid growth in stretchable electronic device research, efforts have been mainly focused on material selection, device geometric design and short-term performance characterization. The present research focuses on the long-term durability of electromechanical and electrochemical performance of buckled carbon nanotube fibers based stretchable conductors and supercapacitors under cyclic deformation. The damage mode and damage evolution as a function of fatigue deformation are identified. After 10,000 stretching-releasing cycles with mechanical deformation up to 40% strain, the conductivities of buckled dry spun and aerogel spun CNT fiber based stretchable conductors exhibit excellent stability and the resistances increase by only about 0.2% and 6%, respectively. The areal specific capacitances of buckled dry spun and aerogel spun CNT fiber based stretchable supercapacitors change, respectively, from 4.42mFcm<SUP>-2</SUP> to 3.60mFcm<SUP>-2</SUP>, and from 8.16mFcm<SUP>-2</SUP> to 9.95mFcm<SUP>-2</SUP> at the scan rate of 50mVs<SUP>-1</SUP> after 10,000 deformation cycles.
Y. Yuan,Z. H. Zhong,Z.S. Yu,H. F. Yin,Y. Y. Dang,X. B. Zhao,Z. Yang,J. T. Lu,J. B. Yan,Y. Gu 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.4
A new Ni-Fe-based superalloy, HT-X, has been developed for applications in 700 °C advanced ultra-supercritical (A-USC) boilers. The HT-X alloy is subjected to various heat treatments. Tensile tests are conducted at room temperature (RT), 700 °C and 750 °C. Creep tests are carried out under conditions of 700 °C/300 MPa and 750 °C/150 MPa. After aging treatment, the yield strength of the HT-X alloy at RT and 750 °C is 787 MPa and 624 MPa, respectively. When additional thermal exposure at 750 °C for 5400 h is applied, the yield strength is decreased to 656 MPa at RT and 480 MPa at 700 °C. For an aged specimen, the a/2<110> dislocation shearing process occurs when tensile testing is conducted at RT and 750 °C. As the γ' precipitate size increases in the specimen that is thermally exposed at 750 °C for 5400 h, Orowan bowing is the dominant dislocation process, and stacking faults develop in the γ' precipitates at both RT and 700 °C. Dislocation slip combined with climb is the dominant mechanism under the creep testing conditions. The factors that affect the mechanical properties and deformation mechanisms are discussed.
N. J. Yu,P. Y. Zhang,Y. J. Shi,M. X. Pan,S. Y. Zhang,H. L. Ge,Y. C. Lu 한국자기학회 2014 Journal of Magnetics Vol.19 No.4
An effective process was employed for synthesizing anisotropic magnetic SmCo7-type alloy flakes with high coercivity, which is highly desirable for many applications. The highest coercivity of 16.3 kOe corresponds to a typical flake thickness of 200 nm for the 3-h ball-milled sample. The anisotropy field was calculated by measuring the parallel and perpendicular directions to the easy magnetization direction of the powders. The anisotropy field decreased with the increase of the ball milling time, thus indicating that the decrease of coercivity was mainly caused by the reduction of the anisotropy field. Microstructure analysis indicated that the morphology, grain size, and anisotropy field of these samples have a great influence on the magnetic properties.
Inverse Analysis of Inconel 718 Laser-Assisted Milling to Achieve Machined Surface Roughness
Yixuan Feng,Tsung-Pin Hung,Yu-Ting Lu,Yu-Fu Lin,Fu-Chuan Hsu,Chiu-Feng Lin,Ying-Cheng Lu,Xiaohong Lu,Steven Y. Liang 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.11
This manuscript proposes an inverse analysis method for the machined surface roughness in laser-assisted milling on Inconel 718. The method solves the forward problem considering the tool profile and the elastic recovery of machined surface and applies the variance-based recursive method to guide the updating mechanism of process parameters to match the measurements. Subsequently, the inverse analysis identifies four process parameters of feed per tooth, tool tip radius, minimum cutting thickness, and tool tip angle, and finds the optimal solution for target performance, the surface roughness. The measurements are collected under the single beam coaxial laser-assisted milling spindle. The proposed modified Kalman filter algorithm introduces the gain coefficient G when updating the process parameters to improve robustness and accuracy. The inverse analysis is conducted on all measurements, and the average error of target performance is 0.460% when the laser is on and 0.394% when the laser is off. The average difference of process parameters is less than 5%, and the selection process is done in 50 loops within a minute. Therefore, the proposed inverse analysis model is robust, adaptive to different initial guesses and measurements, highly accurate, and saves computation time.
수리동력학적 분리장치에 의한 고속 도로 강우유출수의 전처리 기술
우강화(Yu, Jianghua),이치타오(Yi, Qitao),김필주(Kim, Phil-Ju),여미미(Lu, Wei Wei),박성순(Park, Sung-Soon),김영철(Kim, Y.C.) 한국산학기술학회 2009 한국산학기술학회 학술대회 Vol.- No.-
고속도로 교량이나 성토지역 노면이 제공하는 자연적인 위치에너지(동력)를 활용하여 수리학적인 입자상 오염물질 분리장치를 실험실 조건에서 운전한 결과 운전압력 0.5기압(수두 5.6m) 이상에서 90% 이상의 제거효율을 보였다. D50는 약45μm이었는데 입자의 크기가 45 μm 보다 굵은 입자는 거의 대부분제거되지만 45 μm보다 작은 입자의 제거는 쉽지 않음을 시사해주고 있다. 이러한 입자를 제거하기 위한 후속장치가 필요하며 장치의 원활한 운전을 위해서 유지관리문제에 대한 치밀한 검토가 필요하다.
Xu, Jian-Yu,Lu, Shan,Xu, Xiang-Ying,Hu, Song-Liu,Li, Bin,Qi, Rui-Xue,Chen, Lin,Chang, Joe Y. Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Nucleolin (C23) is an important anti-apoptotic protein that is ubiquitously expressed in exponentially growing eukaryotic cells. In order to understand the impact of C23 in radiation therapy, we attempted to investigate the relationship of C23 expression with the radiosensitivity of human non-small cell lung cancer (NSCLC) cells. We investigated the role of C23 in activating the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), which is a critical protein for DNA double-strand breaks (DSBs) repair. As a result, we found that the expression of C23 was negatively correlated with the radiosensitivity of NSCLC cell lines. In vitro clonogenic survival assays revealed that C23 knockdown increased the radiosensitivity of a human lung adenocarcinoma cell line, potentially through the promotion of radiation-induced apoptosis and adjusting the cell cycle to a more radiosensitive stage. Immunofluorescence data revealed an increasing quantity of ${gamma}$-H2AX foci and decreasing radiation-induced DNA damage repair following knockdown of C23. To further clarify the mechanism of C23 in DNA DSBs repair, we detected the expression of DNA-PKcs and C23 proteins in NSCLC cell lines. C23 might participate in DNA DSBs repair for the reason that the expression of DNA-PKcs decreased at 30, 60, 120 and 360 minutes after irradiation in C23 knockdown cells. Especially, the activity of DNA-PKcs phosphorylation sites at the S2056 and T2609 was significantly suppressed. Therefore we concluded that C23 knockdown can inhibit DNA-PKcs phosphorylation activity at the S2056 and T2609 sites, thus reducing the radiation damage repair and increasing the radiosensitivity of NSCLC cells. Taken together, the inhibition of C23 expression was shown to increase the radiosensitivity of NSCLC cells, as implied by the relevance to the notably decreased DNA-PKcs phosphorylation activity at the S2056 and T2609 clusters. Further research on targeted C23 treatment may promote effectiveness of radiotherapy and provide new targets for NSCLC patients.
Yin Lin,Wan Y. Lin,Ji A. Liang,Yu Y. Lu,Hsin Y. Wang,Shih C. Tsai,Chia H. Kao 대한영상의학회 2012 Korean Journal of Radiology Vol.13 No.6
Objective: Neuroendocrine cervical carcinoma is a rare subtype of cervical cancer. These tumors exhibit an aggressive behavior with early regional lymph node and distant metastases. The purpose of our study was to describe five cases of neuroendocrine cervical-vaginal carcinoma and to discuss the potential of the 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) scan for the detection of this rare malignancy. Materials and Methods: Five cases of cervical-vaginal neuroendocrine tumor were retrospectively collected, during a two year (from September 2009 to August 2011) period in our hospital. The clinical staging distributions were International Federation of Gynecology and Obstetrics (FIGO) stage IB2 (1 of 5), stage IIA (3 of 5) and stage IVA (1 of 5). Results: Two cases (cases 1 and 4) were restaged after 18F-FDG PET/CT scan in the initial staging process. Post-treatment 18F-FDG PET/CT scans, in three patients, revealed positive findings for tumor recurrence or lymph node metastases. Two patients (cases 2 and 3) died of tumor within two years. Conclusion: 18F-FDG PET/CT scan is a useful tool in cervical-vaginal neuroendocrine tumor. In its initial staging, the 18F-FDG PET/CT scan may help assess the possible nodal involvement or early hematogeneous spreading. We can also use the 18F-FDG PET/CT to detect local recurrence and to evaluate the treatment response after clinical manipulation. Objective: Neuroendocrine cervical carcinoma is a rare subtype of cervical cancer. These tumors exhibit an aggressive behavior with early regional lymph node and distant metastases. The purpose of our study was to describe five cases of neuroendocrine cervical-vaginal carcinoma and to discuss the potential of the 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) scan for the detection of this rare malignancy. Materials and Methods: Five cases of cervical-vaginal neuroendocrine tumor were retrospectively collected, during a two year (from September 2009 to August 2011) period in our hospital. The clinical staging distributions were International Federation of Gynecology and Obstetrics (FIGO) stage IB2 (1 of 5), stage IIA (3 of 5) and stage IVA (1 of 5). Results: Two cases (cases 1 and 4) were restaged after 18F-FDG PET/CT scan in the initial staging process. Post-treatment 18F-FDG PET/CT scans, in three patients, revealed positive findings for tumor recurrence or lymph node metastases. Two patients (cases 2 and 3) died of tumor within two years. Conclusion: 18F-FDG PET/CT scan is a useful tool in cervical-vaginal neuroendocrine tumor. In its initial staging, the 18F-FDG PET/CT scan may help assess the possible nodal involvement or early hematogeneous spreading. We can also use the 18F-FDG PET/CT to detect local recurrence and to evaluate the treatment response after clinical manipulation.
Lee, S.,Lee, K.S.,Huh, S.,Liu, S.,Lee, D.Y.,Hong, S.,Yu, K.,Lu, B. Cell Press 2016 Developmental cell Vol.37 No.2
<P>Mitochondria play central roles in buffering intracellular Ca2+ transients. While basal mitochondria! Ca2+ (Ca-mito(2+)) is needed to maintain organellar physiology, Ca-mito(2+) overload can lead to cell death. How Ca-mito(2+) homeostasis is regulated is not well understood. Here we show that Miro, a known component of the mitochondrial transport machinery, regulates Drosophila neural stem cell (NSC) development through Ca-mito(2+) homeostasis control, independent of its role in mitochondrial transport. Miro interacts with Ca2+ transporters at the ER-mitochondria contact site (ERMCS). Its inactivation causes Ca-mito(2+) depletion and metabolic impairment, whereas its overexpression results in Ca-mito(2+) overload, mitochondrial morphology change, and apoptotic response. Both conditions impaired NSC lineage progression. Ca-mito(2+) homeostasis is influenced by Polo-mediated phosphorylation of a conserved residue in Miro, which positively regulates Miro localization to, and the integrity of, ERMCS. Our results elucidate a regulatory mechanism underlying Ca-mito(2+) homeostasis and how its dysregulation may affect NSC metabolism/development and contribute to disease.</P>