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RISS 인기검색어
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- 저자 : Yinfeng Li (검색결과 4 건)
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Cuicui Chen,Xiaozhu Liu,Yinfeng Li,Huankun Liang,Kangyan Li,Jiali Li,Chengwu Cheng,Xianpan Liu,Shuhai Zhong,Laiqing Li,Yan Wang 사단법인약침학회 2017 Journal of Acupuncture & Meridian Studies Vol.10 No.4
Allergic contact dermatitis (ACD) is a chronic inflammatory skin disease. Topical corticosteroids are the first-line therapy for ACD despite their significant adverse effects. Acupuncture has been widely used in the treatment of various skin diseases, but its underlying mechanism remains unrevealed. In this study, we investigated the characteristics of acupuncture treatment based on effectiveness and mechanism. BALB/c mice received 1-chloro-2,4-dinitrobenzene (DNCB) application to build AD-like model. Results showed that acupuncture was an effective treatment method in inhibiting inflammatory conditions, serum IgE levels, and expression of proinflammatory cytokine Th2 (IL-4, IL-6), and Th2 (IL-1b, TNF-a) mRNA compared with DNCB treatment. Acupuncture treatment also inhibited nuclear factor-kB p65, phosphorylation of IkBa, and phosphorylation of occludin proteins expression. Furthermore, it could improve the expression of epidermal growth factor in both mRNA and protein levels. These results suggest that acupuncture, as an alternative therapy treatment for its no significant side effects, was effective in alleviating ACD by reducing proinflammatory cytokines and changing proteins’ expression.
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On functionally-graded crashworthy shape of conical structures for multiple load cases
Tong Pang,Yinfeng Li,Hehe Kang,Guangyong Sun,Jianguang Fang,Qing Li 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.6
Many studies on energy absorbers have been focused on tapered tubes because they have significant advantages in crashworthinessand provide a desired constant load-deflection response. However, few studies have been reported on tapered tubes with nonlinearlyvariablediameters along the longitudinal direction. This paper presents thin-walled Functionally graded tapered tube (FGTT) with a diametervarying nonlinearly subject to axial (0°) and oblique (10°, 20°, 30°) impacts. To explore the advantages of FGTT, conventionalStraight/Conical circular tube (SCT/CCT) with the same mass are compared; and FGTTs with a gradient exponent n > 1 are found to bepreferable to others in terms of energy absorption capacity under small impact angles. Then, crashworthiness analyses of different crushingdistances are conducted and it is found that under a large impact angle (e.g. 20°, 30°), FGTT with a short crushing distance (e.g. 40mm) have a higher mean crashing force than long crushing distance (e.g. 120 mm), especially for n > 1. In addition, the effect of geometricparameters, such as the gradient exponent n and diameter range ΔD between top (incident) and bottom (distal) diameters of FGTTs,are also studied and it is found that the FGTT with ΔD = 40 mm and n > 1 exhibits better crashworthiness than the others under smallimpact angles (0°, 10°). This paper demonstrates that such FGTT structures have a certain potential to be an energy absorber.
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A novel adaptive model following controller to enhance steering and roll stability of heavy vehicle
Yongjie Lu,Junning Zhang,Haoyu Li,Yinfeng Han 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.12
In order to improve steering and roll stability for a heavy vehicle, a novel MIMO (multi-input-multi-output) controller is proposed based on an AMFC theory. A vehicle model considering the lateral motion, yaw motion and roll motion is developed. The establishment of reference models, controlled models and iteration algorithm of the feed-back matrix are presented. The Newton iteration method is used to correct the feed-back matrix in the real time, and the ideal control signal is calculated by the integral feed-forward matrix. The state of controlled model can approach reference model to achieve an adaptive online update for the steering control parameters under the transient conditions. The proposed AMFC have a good improvement in reducing side-slip angle, yaw rate and roll angle. The simulation and HIL experiments demonstrate the effectiveness and reliability of the proposed controller in improving the yaw stability and thus preventing rollover when necessary.
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Minghai Han,Weixian Wang,Jianli Zhou,Xun Gong,Cunbin Xu,Yinfeng Li,Qiang Li 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.2
The effects of activation of the unfolded protein response (UPR) via co-expression of the HAC1i gene on the production of the recombinant Pseudomonas aeruginosa elastase (rPAE) in Pichia pastoris GS115 were evaluated in this study. The results showed that expression of the HAC1i gene significantly increased the level of Kar2p (a hallmark of UPR activation) in P. pastoris GS115, demonstrating activation of the UPR. This gene did not affect the growth of yeast in the buffered glycerol-complex medium but stimulated its growth in the buffered methanolcomplex medium. Co-expression of the HAC1i gene enhanced the expression level of the heterogeneously Nglycosylated forms of rPAE, as the caseinolytic activity in the supernatant of the various glycoforms of rPAE expressed in P. pastoris GS115/HAC1 was increased 1.8—3.9-fold compared to that in the control strain P. pastoris GS115, respectively. The stimulating effects of co-expression of the gene on rPAE production were observed when 0.5, 1.0, and 2.0% methanol were added every 24 h, as the caseinolytic activity of supernatants of P. pastoris GS115/HAC1 expressing wild-type of rPAE was increased 3.3-, 1.9-, and 1.7-fold at the corresponding methanol concentration. Further, activation of UPR via co-expression of the HAC1i gene enhanced rPAE secretion in P. pastoris at 20, 24, and 28°C, as the caseinolytic activity of supernatants of P. pastoris GS115/HAC1 expressing wild-type rPAE was increased 2.3-, 2.1-, and 2.8-fold over the tested temperatures.
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