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RISS 인기검색어
- 검색키워드
- 저자 : Yi-Tsung Chiu (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Yi-Tsung Chiu,Tzu-Kang Lin,Hsiao-Hui Hung,Kuo-Chun Chang,Yu-Chi Sung 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.13 No.6
The widening project on Freeway No.1 in Taiwan has a total length of roughly 14 kilometers,and includes three special bridges, namely a 216 m long-span bridge crossing the original freeway, an F-bentdouble decked bridge in a co-constructed section, and a steel and prestressed concrete composite bridge. This study employed in-situ monitoring in conjunction with numerical modeling to establish a real-timemonitoring system for the three bridges. In order to determine the initial static and dynamic behavior of thereal bridges, forced vibration experiments, in-situ static load experiments, and dynamic load experimentswere first carried out on the newly-constructed bridges before they went into use. Structural models of thebridges were then established using the finite element method, and in-situ vehicle load weight, arrangement,and speed were taken into consideration when performing comparisons employing data obtained fromexperimental measurements. The results showed consistency between the analytical simulations andexperimental data. After determining a bridge's initial state, the proposed in-situ monitoring system, which isemployed in conjunction with the established finite element model, can be utilized to assess the safety of abridge's members, providing useful reference information to bridge management agencies.
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Chiu, Yi-Tsung,Lin, Tzu-Kang,Hung, Hsiao-Hui,Sung, Yu-Chi,Chang, Kuo-Chun Techno-Press 2014 Smart Structures and Systems, An International Jou Vol.13 No.6
The widening project on Freeway No.1 in Taiwan has a total length of roughly 14 kilometers, and includes three special bridges, namely a 216 m long-span bridge crossing the original freeway, an F-bent double decked bridge in a co-constructed section, and a steel and prestressed concrete composite bridge. This study employed in-situ monitoring in conjunction with numerical modeling to establish a real-time monitoring system for the three bridges. In order to determine the initial static and dynamic behavior of the real bridges, forced vibration experiments, in-situ static load experiments, and dynamic load experiments were first carried out on the newly-constructed bridges before they went into use. Structural models of the bridges were then established using the finite element method, and in-situ vehicle load weight, arrangement, and speed were taken into consideration when performing comparisons employing data obtained from experimental measurements. The results showed consistency between the analytical simulations and experimental data. After determining a bridge's initial state, the proposed in-situ monitoring system, which is employed in conjunction with the established finite element model, can be utilized to assess the safety of a bridge's members, providing useful reference information to bridge management agencies.
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Antioxidative and Hepatoprotective Effects of Magnolol on Acetaminophen-induced Liver Damage in Rats
Yung-Hsiang Chen,Feng-Yen Lin,Po-Len Liu,Yi-Tsau Huang,Jen-Hwey Chiu,Yi-Chun Chang,Kee-Ming Man,Chuang-Ye Hong,Yen-Yi Ho,Ming-Tsung Lai 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
Acute liver failure (ALF), an often fatal condition characterized by massive hepatocyte necrosis, is frequently caused by drug poisoning, particularly with acetaminophen (N-acetyl-p-aminophenol/APAP). Hepatocyte necrosis is consecutive to glutathione (GSH) depletion and mitochondrial damage caused by reactive oxygen species (ROS) overproduction. Magnolol, one major phenolic constituent of Magnolia officinalis, have been known to exhibit potent antioxidative activity. In this study, the anti-hepatotoxic activity of magnolol on APAP-induced toxicity in the Sprague-Dawley rat liver was examined. After evaluating the changes of several biochemical parameters in serum, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were elevated by APAP (500 mg/kg) intraperitoneal administration (8 and 24 h) and reduced by treatment with magnolol (0.5 h after APAP administration; 0.01, 0.1, and 1 μg/kg). Histological changes around the hepatic central vein, lipid peroxidation (thiobarbituric acid-reactive substance/TBARS), and GSH depletion in liver tissue induced by APAP were also recovered by magnolol treatment. The data show that oxidative stress followed by lipid peroxidation may play a very important role in the pathogenesis of APAP-induced hepatic injury; treatment with lipid-soluble antioxidant, magnolol, exerts anti-hepatotoxic activity. Our study points out the potential interest of magnolol in the treatment of toxic ALF.
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