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Ban, Ju-Yeon,Cho, Soon-Ock,Kwon, Soon-Ho,Kim, Jin-Bae,Song, Nak-Sul,Bae, Ki-Whan,Song, Kyung-Sik,Seng, Yeon-Hee The Korean Society of Medicinal Crop Science 2005 韓國藥用作物學會誌 Vol.13 No.2
Caulis Bambusae in Taenia is widely used in Korea and China due to its various pharmacological activity. The present study aims to investigate the effect of the methanol extract of Caulis Bambusae in Taenia (CB) from Phyllostachys nigra Munro var. henonis Stapf (Gramineae) on amyloid ${\beta}$ protein (25-35) $(A{\beta}\;(25-35))$, a synthetic 25-35 amyloid peptide, -induced neurotoxicity using cultured rat cortical neurons. CB, over a concentration range of $10-50{\mu}g/{\mu}l$, inhibited the $A{\beta}\;(25-35)\;(10\;{\mu}M)$-induced neuronal cell death, as assessed by a 3-[4,5-dimethyIthiazole-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and the number of apoptotic nuclei, evidenced by Hoechst 33342 staining. CB $(50\;{\mu}g/{\mu}l)$ inhibited glutamate release into medium induced by $10\;{\mu}M\;A{\beta}$, (25-35) which was measured by HPLC. Pretreatment of CB $(50\;{\mu}g/{\mu}l)$ inhibited $10{\mu}M\;A{\beta}$ (25-35)-induced elevation of cytosolic calcium concentration $([Ca^{2+}]_c)$, which was measured by a fluorescent dye, fluo-4 AM, and generation of reactive oxygen species. These results suggest that CB prevents $A{\beta}$ (25-35)-induced neuronal ell damage in vitro.
Ban, Ju-Yeon,Cho, Soon-Ock,Jeon, So-Young,Song, Kyung-Sik,Bae, Ki-Hwan,Seong, Yeon-Hee The Korean Society of Medicinal Crop Science 2005 한국약용작물학회지 Vol.13 No.5
Sanguisorbae radix (SR) from Sanguisorba officinalis L. (Losaceae) is widely used in Korea and China due to its various pharmacological activity. The present study aims to investigate the effect of the methanol extract of SR on amyloid ${\beta}$ Protein(25-35) $(A{\beta}\;(25-35))$, a synthetic 25-35 amyloid peptide, -induced neurotoxicity using cultured rat cortical neurons. SR, over a concentration range of $10-50\;{\mu}g/ml$, inhibited the $A{\beta}$ (25-35) $(10\;{\mu}M)-induced$ neuronal cell death, as assessed by a 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and the number of apoptotic nuclei, evidenced by Hoechst 33342 staining. Pretreatment of SR $(50\;{\mu}g/ml)$ inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced} elevation of cytosolic calcium concentration $([Ca^{2+}]c)$, which was measured by a fluorescent dye, fluo-4 AM. SR $(10\;and\;50\;{\mu}g/ml)$ inhibited glutamate release into medium induced by $10\;{\mu}M\;A{\beta}(25-35)$, which was measured by HPLC, and generation of reactive oxygen species. These results suggest that SR prevents $A{\beta}$ (25-35)-induced neuronal cell damage in vitro.
Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit
Ban, Yeon Hee,Lee, Jong Hyun,Gu, Gyo Rim,Lee, Boram,Mo, SangJoon,Kwon, Ho Jeong,Yoon, Yeo Joon The Royal Society of Chemistry 2013 Molecular bioSystems Vol.9 No.5
<P>A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of <I>Streptomyces</I> sp. KCTC 11604BP <I>fkbO</I> deletion mutant with 3-cyclohexene-1-carboxylic acid. The structure of the new compound, 32-dehydroxy-FK506, and its biological activities were determined.</P> <P>Graphic Abstract</P><P>A FK506 analogue containing a non-natural starter unit, 32-dehydroxy-FK506, was obtained through mutational biosynthesis. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2mb25419k'> </P>
Differential Proteomic Analysis of Secreted Proteins from Cutinase-producingBacillus sp. SB-007
Yeon-Hee Ban,Miri Jeon,윤지희,박재민,Hyun-Ju Um,Dae-Soon Kim,Seung-Ki Jung,Keun-Young Kim,Jeewon Lee,민지호,김양훈 한국식물병리학회 2008 Plant Pathology Journal Vol.24 No.2
Bacillus sp. SB-007 was isolated from pea leaves harvested from the southwestern parts of South Korea through screening on a minimal medium containing 0.2% purified cutin for its ability to induce the cutinase production. However, no cutinase was produced when it was grown in a minimal medium containing 0.2% glucose. A proteomic approach was applied to separate and characterize these differentially secreted proteins. The expression level of 83 extracellular proteins of the cutinase-producing Bacillus sp. strain SB-007 incubated in a cutinase-induced medium increased significantly as compared with that cultured in a non cutinase-induced medium containing glucose. The extracellular proteome of Bacillus sp. SB-007 includes proteins from different functional classes, such as enzymes for the degradation of various macromolecules, proteins involved in energy metabolism, sporulation, transport/binding proteins and lipoproteins, stress inducible proteins, several cellular molecule biosynthetic pathways and catabolism, and some proteins with an as yet unknown function. In addition, the two protein spots showed little similarities with the known lipolytic enzymes in the database. These secreted proteome analysis results are expected to be useful in improving the Bacillus strains for the production of industrial cutinases.
Differential Proteomic Analysis of Secreted Proteins from Cutinase-producing Bacillus sp. SB-007
Ban, Yeon-Hee,Jeon, Mi-Ri,Yoon, Ji-Hee,Park, Jae-Min,Um, Hyun-Ju,Kim, Dae-Soon,Jung, Seung-Ki,Kim, Keun-Young,Lee, Jee-Won,Min, Ji-Ho,Kim, Yang-Hoon The Korean Society of Plant Pathology 2008 Plant Pathology Journal Vol.24 No.2
Bacillus sp. SB-007 was isolated from pea leaves harvested from the southwestern parts of South Korea through screening on a minimal medium containing 0.2% purified cutin for its ability to induce the cutinase production. However, no cutinase was produced when it was grown in a minimal medium containing 0.2% glucose. A proteomic approach was applied to separate and characterize these differentially secreted proteins. The expression level of 83 extracellular proteins of the cutinase-producing Bacillus sp. strain SB-007 incubated in a cutinase-induced medium increased significantly as compared with that cultured in a non cutinase-induced medium containing glucose. The extracellular proteome of Bacillus sp. SB-007 includes proteins from different functional classes, such as enzymes for the degradation of various macromolecules, proteins involved in energy metabolism, sporulation, transport/binding proteins and lipoproteins, stress inducible proteins, several cellular molecule biosynthetic pathways and catabolism, and some proteins with an as yet unknown function. In addition, the two protein spots showed little similarities with the known lipolytic enzymes in the database. These secreted proteome analysis results are expected to be useful in improving the Bacillus strains for the production of industrial cutinases.
Characterization of FK506 Biosynthetic Intermediates Involved in Post-PKS Elaboration
Ban, Yeon Hee,Shinde, Pramod B.,Hwang, Jae-yeon,Song, Myoung-Chong,Kim, Dong Hwan,Lim, Si-Kyu,Sohng, Jae Kyung,Yoon, Yeo Joon American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.6
<P>The post-PKS modification steps of FK506 biosynthesis include C9-oxidation and 31-<I>O</I>-methylation, but the sequence of these reactions and the exact route have remained unclear. This study details the post-PKS modification pathways in FK506 biosynthesis through the identification of all intermediates and in vitro enzymatic reactions of the cytochrome P450 hydroxylase FkbD and the methyltransferase FkbM. These results complete our understanding of post-PKS modification steps to FK506 showing the substrate flexibility of two enzymes involved and the existence of two parallel biosynthetic routes to FK506.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-6/np4001224/production/images/medium/np-2013-001224_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np4001224'>ACS Electronic Supporting Info</A></P>