Fenofibrate Increases Radiosensitivity in Head and Neck Squamous Cell Carcinoma via Inducing G2/M Arrest and Apoptosis

Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.

Dynamic Routing Path Selection Algorithm Using Reinforcement Learning in Wireless Ad-Hoc Networks

Qin Yang(양흠),Sang-Jo Yoo(유상조) 한국통신학회 2018 韓國通信學會論文誌 Vol.43 No.7

RESEARCH ARTICLES : Molecular Characterization of Transgenic Rice Producing Resveratrol

( Yang Qin ),( Hong Il Ahn ),( Soon Jong Kweon ),( So Hyeon Baek ),( Kong Sik Shin ),( Hee Jong Woo ),( Hyun Suk Cho ),( Jin Hyoung Lee ),( Myung Ho Lim ) 한국육종학회 2013 Plant Breeding and Biotechnology Vol.1 No.4

Resveratrol, a plant phenolic compound, has potential therapeutic benefits due to its antioxidant properties. This is substantiated by previous studies that show that resveratrol derived from rice grains is an effective treatment agent for metabolic syndrome. Here, we characterized the T-DNA sequence, inserted T-DNA structure, copy number, integrity of the transgene locus, resveratrol synthase gene expression and resveratrol contents in the grains of two resveratrol transgenic rice lines, Iksan515 and Iksan526. The T-DNA transformation vector contained two expression cassettes of the resveratrol synthase gene under the control of the ubiquitin promoter and the bar selection marker gene under the control of the CaMV35S promoter. Flanking sequence analysis indicated that the T-DNAs were inserted into intergenic regions of chromosome 4 for Iksan515 and chromosome 12 for Iksan526. Two T-DNAs connected in an inverted repeat structure at a single locus of the rice genome were identified by whole genome sequencing and Southern blot hybridization in both Iksan515 and Iksan526. No novel open reading frames (ORFs) around insertion sites, sequences encoding allergenic or toxic protein, or other unintended effects by T-DNA insertion were found in either case. In addition, resveratrol synthase gene expression in leaves and resveratrol detection in brown rice grains suggested the successful expression of the inserted foreign resveratrol synthase gene in two transgenic rice lines.

Novel Pilot-Assisted Channel Estimation Techniques for 3GPP LTE Downlink with Performance-Complexity Evaluation

Yang Qin(칭양),Bing Hui(휘빙),KyungHi Chang(장경희) 한국통신학회 2010 韓國通信學會論文誌 Vol.35 No.7

QTL Analysis of Protein Content in Double-haploid Lines of Rice

Yang Qin,Suk-Man Kim,Jae-Keun Sohn 韓國作物學會 2009 한국작물학회지 Vol.54 No.2

The objective of this study was to characterize the main-effect QTLs, epistatic QTLs and QTL-by-environment interactions (QE), which are involved in the control of protein content. A population of 120 doubled haploid (DH) lines derived from a cross between 'Samgang' and 'Nagdong', was planted and determined for protein content over three years. Based on the population and a genetic linkage map of 172 markers, QTL analysis was conducted by WinQTLcart 2.5 and QTLMAPPER. Three main-effect QTLs affecting protein content of brown rice were detected from 2004 to 2006 on chromosomes 1 and 11. The qPC11.2 was repeatedly detected across two years. Seven pairs of epistatic loci were identified on eight chromosomes for protein content and collectively explained 39.15% of phenotype variation. These results suggest that epistatic effects might be an even more important component of the genetic basis for protein content and that the segregation of the DH lines for protein content could be largely explained by a few main-effect QTLs and many epistatic loci.

Crowdfunding Resistance and Adoption: Empirical Evidence from Startups in China Great Bay Area

Qin Yang(양금),Young-Chan Lee(이영찬) 한국아시아학회 2020 아시아연구 Vol.23 No.3

중국 대만구(大灣區) 지역은 홍콩과 마카오의 2개 특별 행정구와 광동성의 9개 도시로 구성되어 있다. 대만구 지역은 중국 전체 수출의 37%를 차지하고 있으며, 2018년 GDP는 1조5천억 달러였다. HSBC 글로벌 리서치에 따르면 현재 GBA의 총 소매가치는 한국과 베트남을 합친 시장 규모와 일본의 3 분의 1에 해당한다. 또한 중국에서 가장 초기에 성공한 경제 특구 중 하나인 심천은 중국 하이테크 수출의 22%를 담당하고 있다. 은행 및 금융 서비스의 경우 홍콩은 본토와의 금융 "슈퍼 커넥터"의 역할을 하고 있다. 또한 중국의 연간 해외직접투자의 약 60%가 홍콩에서 발생하고 있다. 반면 홍콩 및 심천과 같은 대만구의 주요 도시에서 핀테크는 비약적으로 발전하고 있지만 크라우드펀딩 산업은 아직 초기 단계에 있다. 크라우드펀딩은 전 세계적으로 자산관리 전반에 걸쳐 경쟁 패턴을 변화시키고 있다. 혁신적인 정보기술 도입은 자산관리 산업의 통합을 촉진하는 동시에 차별화된 경쟁 기회를 제공하고 있다. 본 논문은 혁신확산이론, 현상유지 편향이론 및 행동추론이론 등을 사용하여 대만구 지역의 스타트업에서 크라우드펀딩 서비스의 저항과 채택에 영향을 미치는 요인을 밝혀내는 것을 목표로 한다. 첨단 정보기술을 갖춘 경제 중심지인 대만구는 금융과 기술을 결합할 수 있는 이상적인 지역이다. 재무와 기술은 모두 대만구의 향후 개발에 결정적인 역할을 담당하기 때문에 매우 중요한 이슈라고 할 수 있다. 본 연구는 크라우드 펀딩 도입에 있어서의 장애요인의 전략적 의미를 탐구하고 이러한 장애요인을 극복하기 위한 방안을 크라우드펀딩 플랫폼 관리 관점에서 제안하고자 한다. The China Great Bay Area (GBA) is composed of the two Special Administrative Regions of Hong Kong and Macao, and nine cities in Guangdong province. It accounts for 37% of China’s total exports, and its GDP was USD1.5 trillion in 2018 (Sataista, 2019). According to HSBC Global Research, currently, the total retail value of GBA is equivalent to the combined market size of South Korea and Vietnam, and a third of Japan’s. Moreover, as one of China"s earliest and most successful special economic zones in China, Shenzhen produces 22% of China’s high-tech exports. As to banking and financial services, as to Hong Kong, it acts as the role of a financial “super-connector” with the mainland. About 60% of all China’s annual overseas direct investment comes from Hong Kong. On the flip side, although Fintech developments in main cities of the GBA such as Hong Kong and Shenzhen are phenomenal, crowdfunding industry still at an early stage here. Crowdfunding is changing competition patterns across asset management globally. The use of technology has facilitated the integration of the asset management industry, while also providing opportunities for differentiated competition. This paper aims to identify factors influencing on the resistance of crowdfunding services in startups in bay area by employing the innovation diffusion theory, status quo bias theory, and behavioral reasoning theory. As an economic center with advanced information technology, GBA is an ideal place to combine finance and technology. Finance and technology are critical working priorities for the bay area, because they all play decisive roles in GBA’s future development. This research will explore the strategic implications of the barriers of crowdfunding, and recommendations to overcome those barriers will be proposed as part of management of crowdfunding platforms.

Nutritional composition analysis for beta-carotene-enhanced transgenic soybeans (Glycine max L.)

Yang Qin,박수윤,오선우,임명호,신공식,조현석,이성곤,우희종 한국응용생명화학회 2017 Applied Biological Chemistry (Appl Biol Chem) Vol.60 No.3

Nutritional composition is important for assessing the safety of genetically modified (GM) crops for human consumption. Three beta-carotene-enhanced soybean lines were developed by introducing the b-conglycinin promoter:: Phytoene synthase-2A-Carotene desaturase/t35S gene cassette into the genome of the commercial Kwangan (Glycine max L.) soybean variety. Transgenic soybeans were successfully detected on beta-carotene productions ranged from 170.47 to 213.58 lg/g. Comparative assessments of nutrition were conducted with 3 transgenic soybeans, their non-GM counterpart, and several commercial soybean varieties. Results indicated that most levels of proximate, fatty acids, amino acids, and vitamins showed non-significant differences between transgenic soybeans and their counterpart, and fit within the reference ranges established for other commercial soybeans and Organization for Economic Cooperation and Development Guidelines. However, significant differences on levels of crude fat, carbohydrate, d-tocopherol, and oleic acid of transgenic soybeans comparing to those of non-transgenic counterpart Kwangan cannot eliminate the influences of transgene insertion. Alternations on compositions should be definite by further studies, such as transcriptome and metabolome profiling.

QTL Analysis of Protein Content in Double-haploid Lines of Rice

Qin, Yang,Kim, Suk-Man,Sohn, Jae-Keun The Korean Society of Crop Science 2009 한국작물학회지 Vol.54 No.2

The objective of this study was to characterize the main-effect QTLs, epistatic QTLs and QTL-by-environment interactions (QE), which are involved in the control of protein content. A population of 120 doubled haploid (DH) lines derived from a cross between 'Samgang' and 'Nagdong', was planted and determined for protein content over three years. Based on the population and a genetic linkage map of 172 markers, QTL analysis was conducted by WinQTLcart 2.5 and QTLMAPPER. Three main-effect QTLs affecting protein content of brown rice were detected from 2004 to 2006 on chromosomes 1 and 11. The qPC11.2 was repeatedly detected across two years. Seven pairs of epistatic loci were identified on eight chromosomes for protein content and collectively explained 39.15% of phenotype variation. These results suggest that epistatic effects might be an even more important component of the genetic basis for protein content and that the segregation of the DH lines for protein content could be largely explained by a few main-effect QTLs and many epistatic loci.

Genomic Variations of Rice Regenerants from Tissue Culture Revealed by Whole Genome Re-Sequencing

( Yang Qin ),( Kong-sik Shin ),( Hee-jong Woo ),( Myung-ho Lim ) 한국육종학회 2018 Plant Breeding and Biotechnology Vol.6 No.4

Plant tissue culture is a technique that has invariably been used for various purposes such as obtaining transgenic plants for crop improvement or functional analysis of genes. However, this process can be associated with a variety of genetic and epigenetic instabilities in regenerated plants, termed as somaclonal variation. In this study, we investigated mutation spectrum, chromosomal distributions of nucleotide substitution types of single-nucleotide polymorphisms (SNPs) and insertions/deletions (InDels) by whole genome re-sequencing between Dongjin and Nipponbare along with regenerated plants of Dongjin from different induction periods. Results indicated that molecular spectrum of mutations in regenerated rice against Dongjin genome ranged from 9.14 × 10 ^-5to 1.37 × 10 ^-4during one- to three-month callus inductions, while natural mutation rate between Dongjin and Nipponbare genomes was 6.97 × 10 ^-4. Non-random chromosome distribution of SNP and InDel was observed in both regenerants and Dongjin genomes, with the highest densities on chromosome 11. The transition to transversion ratio was 2.25 in common SNPs of regenerants against Dongjin genome with the highest C/T transition frequency, which was similar to that of Dongjin against Nipponbare genome.

Probabilistic Q-learning for Ad-hoc network routing with dynamic wireless environment conditions

Qin Yang,Sang-Jo Yoo 한국통신학회 2018 한국통신학회 학술대회논문집 Vol.2018 No.1