http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Le,Xuan Truong 한국유통과학회 2019 KODISA ICBE (International Conference on Business Vol.2019 No.-
Tax procedures are factors that strongly affect the business environment. A simple and convenient tax procedures system will contribute to a good business environment by easing of tax returns preparation, reducing tax compliance costs and preventing corruption. This paper examines the results and impacts of previous tax procedures reform to Vietnam’s business environment, identifies challenges of tax procedures reform now and the coming years, and discusses areas where further reforms are needed to sustain tax revenue and reduce compliance costs including: (i) Transparent and comprehensive guidance to all tax laws and other legal tax documents; (ii) Widening the application of risk management in tax administration; (iii) Continuing simplification of tax procedures; and (iv) Development of IT in tax administration.
Le Xuan Nguyen, Truong,Ahn, Jee-Yin Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.6
Src homology (SH) domains of phospholipase C-$\gamma1$ (PLC-$\gamma1$) impair NGF-mediated PC12 cells differentiation. However, whether the enzymatic activity is also implicated in this process remains elusive. Here, we report that the enzymatic activity of phospholipase C-$\gamma1$ (PLC-$\gamma1$) is at least partially involved to the blockage of neuronal differentiation via an abrogation of MAPK activation, as well as sustained Akt activation. By contrast, Overexpression of WT-PLC-$\gamma1$ exhibited sustained NGF-induced MAPK activation, and triggered transient Akt activation resulting in profound inhibition of neurite outgrowth. However, lipase-inactive mutant (LIM) PLC-$\gamma1$ cells fail to suppress neurite outgrowth, although it contains intact SH domains, specifically enhancing the expression of cyclin D1 and p21 proteins, which regulate the function of retinoblastoma Rb protein. These observations show that the lipase inactive mutant of PLC-$\gamma1$ does not alter NGF-induced neuronal differentiation via enzymatic inability and the modulation of cell cycle regulatory proteins independent on SH3 domain.
The effective model of the human Acetyl-CoA Carboxylase inhibition by aromatic-structure inhibitors
Nguyen Truong Cong Minh,Bui Tho Thanh,Le Xuan Truong,Nguyen Thi Bang Suong,Le Thi Xuan Thao 한국전기전자학회 2017 전기전자학회논문지 Vol.21 No.3
The research investigates the inhibition of fatty acid biosynthesis of the human Acetyl-CoA Carboxylase enzyme by the aromatic-structure inhibitors (also known as ligands) containing variables of substituents, contributing an important role in the treatment of fatty-acid metabolic syndrome expressed by the group of cardiovascular risk factors increasing the incidence of coronary heart disease and type-2 diabetes. The effective interoperability between ligand and enzyme is characterized by a 50% concentration of enzyme inhibitor (IC50) which was determined by experiment, and the factor of geometry structure of the ligands which are modeled by quantum mechanical methods using HyperChem 8.0.10 and Gaussian 09W softwares, combining with the calculation of quantum chemical and chemico-physical structural parameters using HyperChem 8.0.10 and Padel Descriptor 2.21 softwares. The result data are processed with the combination of classical statistical methods and modern bioinformatics methods using the statistical softwares of Department of Pharmaceutical Technology – Jadavpur University – India and R v3.3.1 software in order to accomplish a model of the quantitative structure - activity relationship between aromatic-structure ligands inhibiting fatty acid biosynthesis of the human Acetyl-CoA Carboxylase.
Interaction of TIF-90 and filamin A in the regulation of rRNA synthesis in leukemic cells
Nguyen, Le Xuan Truong,Chan, Steven M.,Ngo, Tri Duc,Raval, Aparna,Kim, Kyeong Kyu,Majeti, Ravindra,Mitchell, Beverly S. American Society of Hematology 2014 Blood Vol.124 No.4
<P>The transcription initiation factor I (TIF-IA) is an important regulator of the synthesis of ribosomal RNA (rRNA) through its facilitation of the recruitment of RNA polymerase I (Pol I) to the ribosomal DNA promoter. Activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, which occurs commonly in acute myelogenous leukemia, enhances rRNA synthesis through TIF-IA stabilization and phosphorylation. We have discovered that TIF-IA coexists with a splicing isoform, TIF-90, which is expressed preferentially in the nucleolus and at higher levels in proliferating and transformed hematopoietic cells. TIF-90 interacts directly with Pol I to increase rRNA synthesis as a consequence of Akt activation. Furthermore, TIF-90 binds preferentially to a 90-kDa cleavage product of the actin binding protein filamin A (FLNA) that inhibits rRNA synthesis. Increased expression of TIF-90 overcomes the inhibitory effect of this cleavage product and stimulates rRNA synthesis. Because activated Akt also reduces FLNA cleavage, these results indicate that activated Akt and TIF-90 function in parallel to increase rRNA synthesis and, as a consequence, cell proliferation in leukemic cells. These results provide evidence that the direct targeting of Akt would be an effective therapy in acute leukemias in which Akt is activated.</P>
The effective model of the human Acetyl-CoA Carboxylase inhibition by aromatic-structure inhibitors
Minh, Nguyen Truong Cong,Thanh, Bui Tho,Truong, Le Xuan,Suong, Nguyen Thi Bang,Thao, Le Thi Xuan Institute of Korean Electrical and Electronics Eng 2017 전기전자학회논문지 Vol.21 No.3
The research investigates the inhibition of fatty acid biosynthesis of the human Acetyl-CoA Carboxylase enzyme by the aromatic-structure inhibitors (also known as ligands) containing variables of substituents, contributing an important role in the treatment of fatty-acid metabolic syndrome expressed by the group of cardiovascular risk factors increasing the incidence of coronary heart disease and type-2 diabetes. The effective interoperability between ligand and enzyme is characterized by a 50% concentration of enzyme inhibitor ($IC_{50}$) which was determined by experiment, and the factor of geometry structure of the ligands which are modeled by quantum mechanical methods using HyperChem 8.0.10 and Gaussian 09W softwares, combining with the calculation of quantum chemical and chemico-physical structural parameters using HyperChem 8.0.10 and Padel Descriptor 2.21 softwares. The result data are processed with the combination of classical statistical methods and modern bioinformatics methods using the statistical softwares of Department of Pharmaceutical Technology - Jadavpur University - India and R v3.3.1 software in order to accomplish a model of the quantitative structure - activity relationship between aromatic-structure ligands inhibiting fatty acid biosynthesis of the human Acetyl-CoA Carboxylase.
Lan, Truong Thi Phuong,Huy, Nguyen Duc,Luong, Nguyen Ngoc,Quang, Hoang Tan,Tan, Trinh Huu,Thu, Le Thi Anh,Huy, Nguyen Xuan,Loc, Nguyen Hoang The Korean Society of Plant Biotechnology 2019 식물생명공학회지 Vol.46 No.3
The aim of this study is to evaluate the effect of yeast extract (YE) and salicylic acid (SA) on the expression of curcuminoid-biosynthesis genes (CzDCS and CURS1-3), and accumulation of curcumin in Curcuma zedoaria cell cultures. The results showed that, in cells treated with YE or SA, the expression levels of curcuminoid genes were 1.14- to 3.64-fold higher than the control (untreated cells), in which the YE exhibited a stronger effect in comparison with SA. Curcumin accumulation also tended to be similar to gene expression, curcumin contents in YE- or SA-treated cells were 1.61- to 2.53-fold higher than the control. The SA treatment at the fifth day of culture stimulated the curcumin accumulation and expression in all four genes compared to that at the beginning. While the YE treatments gave different results, the CzCURS1 and CzCURS3 genes were expressed strongly in cells that were treated at the beginning. However, the CzDCS and CzCURS2 genes showed the opposite expression pattern, they were activated strongly in the treatments at day five of the culture. However, the content of curcumin reached its maximum value on the fifth day of culture in all investigations.
Aerodynamic Performance of an Annular Combustion Chamber Cooling with Swirler Design
Cong-Truong Dinh,Xuan-Truong Le,Trong-Nghia Hoang,Quang-Anh Pham 한국유체기계학회 2021 International journal of fluid machinery and syste Vol.14 No.1
Gas turbines play a crucial role in the aviation industry as they are primary sources of power for most aircraft. The combustion chamber is one of the three essential part of jet engines, together with compressor and turbine. Energy is generated when fuel is burned in the combustor. In the primary zone, the recirculation flow is of great importance to aerodynamic performance. Swirlers, fitted in the dome around the fuel injector, can alter the behavior of the recirculation flow and thus, impact combustion performance. The vortex behind a swirler can be easily controlled by changing the swirl angle. In addition, changing the vortex angle leads to a difference in mixing between fuel and air. This paper investigates the effects of swirler design, based on the swirl angle, on aerodynamic performance of an annular combustion chamber in cooling condition using three-dimensional Reynolds-averaged Navier-Stokes equations with the SST turbulence model.
A New Dimeric Lignan from the Stems of Willughbeia edulis
Nguyen, Hai Xuan,Do, Truong Nhat Van,Le, Tho Huu,Dang, Phu Hoang,Nguyen, Mai Thanh Thi,Nguyen, Nhan Trung The Korean Society of Pharmacognosy 2022 Natural Product Sciences Vol.28 No.2
As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure of 1 has been suggested to have two 2-substituted 4-chromanone subunits with different stereochemical configurations. In addition, the MS/MS analysis of the products obtained by acid-catalyzed hydrolysis of 1 was supportive of its structure. Unfornatually, the new compound 1 did not show 𝛼-glucosidase inhibitory activity with an IC<sub>50</sub> value > 250 𝜇M.