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Min Cui,Xia Li,Yahong Zhang,Shanshan Liu,Weidong Xie,Mei Ji,Hongxiang Lou 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.8
A novel eudesmane-type sesquiterpene compound, 1-oxoeudesm-11(13)-eno-12,8a-lactone (OEL), was isolated from Aster himalaicus. Its effect on apoptosis in human breast adenocarcinoma (MCF-7) cells was investigated. MTT assay showed that OEL substantially reduced the viability of KB, MCF-7, U87, A172, and MG-63 cells. MCF-7 cells were used to further evaluate the antitumor effects and anticancer mechanisms of OEL. OEL-induced apoptosis was characterized by chromatin condensation, formation of apoptotic bodies, and phosphatidylserine on extracellular surface; these effects were confirmed by DAPI nuclear staining and flow cytometry. Increased expression of Bax and deceased expression of Bcl-2 were also observed in OELtreated MCF-7 cells. Moreover, OEL induced the loss of mitochondria membrane potential, release of cytochrome C, activation of caspase-9, and generation of reactive oxygen species. These findings indicate that reactive oxygen species generation and mitochondria activation were involved in apoptosis induced by OEL in MCF-7 cells. The results from our study demonstrated that OEL may be a promising pro-apoptotic compound that could be used to develop novel anticancer drugs.
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Jintao Li,Peng Wei,Yahong Xie,Ziteng Liu,Hongjie Chen,Long He 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-
Hydrogels have been widely adopted for in-depth water control in mature oilfields, however, the poormechanical properties limit their application. Herein, a conjoined-network induced hydrogel was preparedthrough the in-situ free radical copolymerization of acrylamide (AM), Acrylic acid (AA) and N,N0-methylenebis(acrylamide) (MBA) in the presence of nano-cellulose (CNF/ACNF), and the coordinationeffect between aluminium ion and carboxyl. The results showed that a small amount of nano-cellulose(0.2 %) increased the compressive strength of the hydrogel by 7 times. The presence of nano-celluloseendowed the hydrogel with excellent thermal stability and high shearing elasticity, at the same time,could effectively reduced the swelling rate that hindered its disintegration in practical application. Theevaluation of sand-pack plugging suggested that the double cross-linked nano-cellulose hydrogel presenteda significant capacity for efficient water plugging, where the breakthrough pressure gradientwas as high as 23.73 MPa, the plugging rate reached 99.9%, and the maximum residual resistance factorwas 3902.06. This work provided a novel design of hydrogel with high compressive strength and satisfactorystability for water shutoff and conformance control in heterogeneous oil reservoirs.
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Suppression of stray electrons in the negative ion accelerator of CRAFT NNBI test facility
Yang Yuwen,Wei Jianglong,Xie Junwei,Gu Yuming,Xie Yahong,Hu Chundong 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.3
Comprehensive Research Facility for Fusion Technology (CRAFT) is an integration of different demonstrating or testing facilities, which aim to develop the critical technology or composition system towards the fusion reactor. Due to the importance and challenge of the negative ion based neutral beam injection (NNBI), a NNBI test facility is included in the framework of CRAFT. The initial object of CRAFT NNBI test facility is to obtain a H0 beam power of 2 MW at the energy of 200e400 keV for the pulse duration of 100 s. Inside the negative ion accelerator of NNBI system, the interactions of the negative ions with the background gas and electrodes can generate abundant stray electrons. The stray electrons can be further accelerated and dumped on the electrodes or eject from the accelerator. The stray electrons, including the ejecting electrons, cause the unwanted particle and heat flux onto the electrodes and the inner components of beamline (especially the temperature sensitive cryopump). The suppression of the stray electrons from the CRAFT accelerator is carried out via a series of design and simulation works. The paper focuses the influence of different magnetic field configurations on the stray electrons and the character of the ejecting electrons.
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