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- 저자 : Xiaofan Lv (검색결과 2 건)
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Wenjie Ma,Bing Zhao,Xiaofan Lv,Xuan Feng 한국원예학회 2022 Horticulture, Environment, and Biotechnology Vol.63 No.1
Heavy metal contamination of soil is a serious environmental problem worldwide. With improving ecological awareness,phytoremediation has attracted increasing attention as an economic, effi cient, and environmentally friendly method to addressheavy metal pollution. Hydrangea plants are not only colorful and aesthetically pleasing, but they also grow vigorously. Inthis study, we examined the responses of three Hydrangea cultivars to diff erent levels of lead (Pb) stress in terms of theirgrowth responses, biochemical changes, and heavy metal accumulation. We found that (1) no visual heavy metal toxicitysymptoms were observed in the three Hydrangea cultivars under any Pb treatment. (2) At low concentrations of Pb (100–200 mg kg −1 ), the root length of the three cultivars increased signifi cantly compared with that of the control; no signifi cantchange was found in shoot biomass in the three cultivars under any Pb treatment. (3) The biochemical changes in responseto Pb stress diff ered between the cultivars. (4) Under all Pb treatments, the Pb concentrations in the roots were signifi cantlyhigher than those in the shoots of the cultivars, with translocation factor (TF) values < 1. Our results suggest that all threeHydrangea cultivars tested have the potential to tolerate high Pb levels in soil and showed Pb phytostabilization tendencieswith features essential for phytoextraction.
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Fei Xiaowei,Dou Ya-nan,Sun Kai,Wei Jialiang,Guo Qingdong,Wang Li,Wu Xiuquan,Lv Weihao,Jiang Xiaofan,Fei Zhou 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The tripartite motif (TRIM) 22 and mitogen-activated protein kinase (MAPK) signaling pathways play critical roles in the growth of glioblastoma (GBM). However, the molecular mechanism underlying the relationship between TRIM22 and MAPK signaling remains unclear. Here, we found that TRIM22 binds to exon 2 of the sphingosine kinase 2 (SPHK2) gene. An ERK1/2-driven luciferase reporter construct identified TRIM22 as a potential activator of MAPK signaling. Knockout and overexpression of TRIM22 regulate the inhibition and activation of MAPK signaling through the RING-finger domain. TRIM22 binds to Raf-1, a negative regulator of MAPK signaling, and accelerates its degradation by inducing K48-linked ubiquitination, which is related to the CC and SPRY domains of TRIM22 and the C1D domain of Raf-1. In vitro and in vivo, an SPHK2 inhibitor (K145), an ERK1/2 inhibitor (selumetinib), and the nonphosphorylated mutant Raf-1S338A inhibited GBM growth. In addition, deletion of the RING domain and the nuclear localization sequence of TRIM22 significantly inhibited TRIM22-induced proliferation of GBM cells in vivo and in vitro. In conclusion, our study showed that TRIM22 regulates SPHK2 transcription and activates MAPK signaling through posttranslational modification of two critical regulators of MAPK signaling in GBM cells.
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