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Xiaobin Gao,Song Mei,Xueyong Yong,Danyu Zhao,Jinpeng Bao,Jianping Deng 한국섬유공학회 2019 Fibers and polymers Vol.20 No.11
Poly(methyl methacrylate) (PMMA) has found a lot of practical uses, however, how to efficiently and costeffectivelyimprove its relatively low thermal properties remains as an intractable academic challenge. This article reports anovel strategy for improving heat-resistance of PMMA by using biomass syringaldehyde. Syringaldehyde methacrylate(SMA) was first synthesized and then used as comonomer to copolymerize with methyl methacrylate (MMA) through bulkpolymerization and solution polymerization. The copolymers can be obtained in high yield and demonstrate remarkablyimproved heat-resistance according to differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA) andderivative thermogravimetry analyses (DTG). Moreover, the modified PMMA still maintains good light transmittance invisible range. The study provides a new alternative for modifying PMMA, and the modified PMMA may find newapplications as heat-resistant polymeric material which cannot routinely achieved by PMMA itself. In addition, SMA as anew type of green heat-resistant modifier derived from renewable biomass syringaldehyde may have potential applications inheat-resistant modification of materials.
Wenshuai Lin,Xiaomeng Li,Deyin Yao,Xiaobin Gao,Qi Zhou 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.7
This paper investigates the event-triggered sliding mode control problem for discrete-time Markov jumpsystems under the unavailable states and partially unknown transition probabilities. To save the limited computational source, an event-triggered scheme is implemented to determine whether the current data should be sentor not, and an observer is constructed to estimate the unmeasurable states of the system. Then, on the basis ofthe Lyapunov functional technique, the sufficient conditions of stochastic stability for the closed-loop system arederived. Moreover, the sliding mode controller based on event-triggered mechanism is designed to ensure that thestate trajectories of the closed-loop system can be driven onto the predefined sliding manifold and maintain therefor all subsequent time. Finally, a numerical example is utilized to demonstrate the effectiveness of the proposedmethod.
Wu Hao,Wei Guoli,Luo Lixia,Li Lingchang,Gao Yibo,Tan Xiaobin,Wang Sen,Chang Haoxiao,Liu Yuxi,Wei Yingjie,Song Jie,Zhang Zhenhai,Huo Jiege 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Combination of chemotherapy and immune checkpoint inhibitor therapy has greatly improved the anticancer effect on multiple malignancies. However, the efficiency on triple-negative breast cancer (TNBC) is limited, since most patients bear “cold” tumors with low tumor immunogenicity. Doxorubicin (DOX), one of the most effective chemotherapy agents, can induce immunogenic cell death (ICD) and thus initiating immune response.In this study, to maximize the ICD effect induced by DOX, chitosan and cell-penetrating peptide (R6F3)-modified nanoparticles (PNPs) loaded with ginsenoside Rg3 (Rg3) were fabricated using the self-assembly technique, followed by co-encapsulation with DOX based on thermo-sensitive hydrogel. Orthotopic tumor model and contralateral tumor model were established to observe the antitumor efficacy of the thermo-sensitive hydrogel combined with anti-PD-L1 immunotherapy, besides, the biocompatibility was also evaluated by histopathological.Rg3-PNPs strengthened the immunogenic cell death (ICD) effect induced by DOX. Moreover, the hydrogel co-loading Rg3-PNPs and DOX provoked stronger immune response in originally nonimmunogenic 4T1 tumors than DOX monotherapy. Following combination with PD-L1 blocking, substantial antitumor effect was achieved due to the recruitment of memory T cells and the decline of adaptive PD-L1 enrichment.The hydrogel encapsulating DOX and highly permeable Rg3-PNPs provided an efficient strategy for remodeling immunosuppressive tumor microenvironment and converting immune “cold” 4T1 into “hot” tumors.