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        An Electrochemical Sensor Based on Graphene-Polypyrrole Nanocomposite for the Specific Detection of Pb (II)

        Rong Rong,Huimin Zhao,Xiao Rong Gan,Shuo Chen,Xie Quan 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.1

        An electrochemical sensor for the rapid, selective and sensitive detection of Pb2+ was developed using polypyrrole-graphene (PPY-rGO) nanocomposite by electrochemical synthesis. The PPYrGO-modified electrode possessed a large effective area because of unique 3D porous architectures, and it displayed excellent selectivity for the determination of Pb2+. The response of Pb2+ on the nanocomposite-modified electrode was evaluated, and the relevant parameters were optimized by square wave anodic stripping voltammetry (SWASV). The stripping response was highly linear (R2 = 0.987) over a Pb2+ concentration range of 5 X 10-9 mol/L to 7.5 X 10-7 mol/L, with a detection limit of 4.7 X 10-11 mol/L (3σ method). Furthermore, its applicability was validated for the determination of Pb2+ levels using spiked tap water at different concentrations. The polyporous structure, satisfactory reproducibility, long-term stability and simple synthesis endow the PPY-rGO nanocomposite a promising application in the determination of Pb2+.

      • Association Between Polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln Genes and Prognosis of Colorectal Cancer in a Chinese Population

        Gan, Yi,Li, Xiao-Rong,Chen, Dao-Jin,Wu, Jun-Hui Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

        We conducted this study to detect associations between XRCC1 Arg399Gln and XPD Lys751Gln genotypes and survival of colorectal cancer patients treated with 5-FU/oxalipatin chemotherapy. We included 289 Chinese patients with advanced colorectal cancer, who had received 5-FU/oxalipatin chemotherapy as first-line treatment from January 2005 to January 2007. All patients were followed up till Nov. 2011. Genotyping for XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms was based upon duplex polymerase-chain-reaction with the PCR-RFLP method. In our study, we found the XRCC1 399 Gln/Gln genotype to confer significantly higher rates of response to chemotherapy when compared to the Arg/Arg genotype [OR (95% CI)= 2.56(1.57-2.55)]. patients with the XPD 751 Gln/Gln genotype had significantly higher rates of response to chemotherapy [OR (95% CI)= 1.54(0.87-2.65)] and those with the XRCC1 399 Gln/Gln genotype had a longer average survival time and significantly lower risk of death than did those with the Arg/Arg genotype [HR (95% CI)= 0.66(0.36-0.95)]. Similarly, those carrying the XPD 751Gln/Gln genotype had 0.51-fold the risk of death of those with XPD 751Lys/Lys [HR (95% CI)= 0.51(0.33 -0.94)]. In conclusion, it is suggested that the XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms should be routinely assessed to determine colorectal patients who are more likely to benefit from 5-FU/oxalipatin chemotherapy.

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        Characterization of SiC/C Nanocomposite Powders Synthesized by Arc-Discharge

        Zhou, Lei,Yu, Jie Yi,Gao, Jian,Wang, Dong Xing,Gan, Xiao Rong,Xue, Fang Hong,Huang, Hao,Dong, Xing Long Korean Society of Microscopy 2015 Applied microscopy Vol.45 No.4

        In this paper, three carbon sources, i.e., solid graphite, gaseous CH4 and liquid ethanol, and one solid silicon source were employed to synthesize SiC/C nanocomposite powders by arc-discharge plasma. The processing conditions such as the component ratios of raw materials, atmospheric gases, etc. were adjusted for controllable synthesis of the nanopowders. It is indicated that both of solid graphite and silicon can be co-evaporated and reacted to form nanophases of cubic ${\beta}$-SiC with ~50 nm in mean size and a little free graphite; the carbon atoms decomposed from gaseous $CH_4$ favor to combine with the evaporated silicon atoms to form the dominant SiC nanophase; liquid carbon source of ethanol can also be used to harvest the main ${\beta}$-SiC and minor 6H-SiC phases in the assembly of nanoparticles. The as-prepared SiC/C nanocomposite powders were further purified by a heat-treatment in air and their photocatalytic performances were then greatly improved.

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