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Guohua Yang,Xavier N. Siwe,Alain S. Leutou,Zhile Feng,장대해,Hong Dae Choi,강정숙,손병화,Viviane N. Nenkep 한국생약학회 2009 Natural Product Sciences Vol.15 No.3
The crude extract of the mycelium of Cladosporium was found to exhibit antimicrobial activity against the Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. Bioassayguided fractionation of an organic extract led to the isolation of an acetophenone derivative, clavatol (2',4'- dihydroxy-3',5'-dimethylacetophenone) (1), and a benzodiazepine alkaloid, circumdatin A (2). Compound 1 showed moderate antibacterial activity against S. aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus with minimum inhibitory concentration (MIC) values of 62.5, 62.5, 31.0 µg/mL, respectively, but compound 2 was inactive. Compounds 1 and 2 exhibited UV-A protection activity with ED50 values of 227.0 and 82.0 µM, respectively, indicating that they were more potent than the positive control, oxybenzone (ED50 350 µM), a common sunscreen agent.
Microbial Transformation of a Monoterpene, Geraniol, by the Marine-derived Fungus Hypocrea sp.
Alain S. Leutou,Guo Hua Yang,Viviane N. Nenkep,Xavier N. Siwe,Zhi Le Feng,Thang T. Khong,Hong Dae Choi,Jung Sook Kang,Byeng Wha Son 한국미생물 · 생명공학회 2009 Journal of microbiology and biotechnology Vol.19 No.10
Bioactive Cyclopentenone Derivatives from Marine Isolates of Fungi
Zhile Feng,Alain S. Leutou,Guohua Yang,Viviane N. Nenkep,Xavier N. Siwe,Byeng Wha Son,Hong Dae Choi,강정숙 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.10
As part of an effort to discover bioactive natural products from marine sources, we investigated the bioactive secondary metabolites from two marine isolates of the fungi, Trichoderma viride and Rhizopus stolonifer. Three cyclopentenones, myrothenones A (1) and B (2) and trichodenone A (3), were isolated from T. viride and two cyclopentenones, 2-bromomyrothenone B (4) and botrytinone (5), were isolated from R. stolonifer. The molecular structures and absolute stereochemistries of the cyclopentenones were determined from chemical and physicochemical evidence, including quantum chemistry calculations, X-ray analysis, and the circular dichroism (CD) exciton chirality method. Myrothenone A (1) displays tyrosinase inhibitory activity, with an IC50 value of 6.6 μM,and is therefore more active than the positive control, kojic acid.
Bioactive Cyclopentenone Derivatives from Marine Isolates of Fungi
Feng, Zhile,Leutou, Alain S.,Yang, Guohua,Nenkep, Viviane N.,Siwe, Xavier N.,Choi, Hong-Dae,Kang, Jung-Sook,Son, Byeng-Wha Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.10
As part of an effort to discover bioactive natural products from marine sources, we investigated the bioactive secondary metabolites from two marine isolates of the fungi, Trichoderma viride and Rhizopus stolonifer. Three cyclopentenones, myrothenones A (1) and B (2) and trichodenone A (3), were isolated from T. viride and two cyclopentenones, 2-bromomyrothenone B (4) and botrytinone (5), were isolated from R. stolonifer. The molecular structures and absolute stereochemistries of the cyclopentenones were determined from chemical and physicochemical evidence, including quantum chemistry calculations, X-ray analysis, and the circular dichroism (CD) exciton chirality method. Myrothenone A (1) displays tyrosinase inhibitory activity, with an I$C_{50}$ value of 6.6 ${\mu}M$, and is therefore more active than the positive control, kojic acid.