PATN: Polarized Attention based Transformer Network for Multi-focus image fusion

Pan Wu,Zhen Hua,Jinjiang Li 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.4

In this paper, we propose a framework for multi-focus image fusion called PATN. In our approach, by aggregating deep features extracted based on the U-type Transformer mechanism and shallow features extracted using the PSA module, we make PATN feed both long-range image texture information and focus on local detail information of the image. Meanwhile, the edge-preserving information value of the fused image is enhanced using a dense residual block containing the Sobel gradient operator, and three loss functions are introduced to retain more source image texture information. PATN is compared with 17 more advanced MFIF methods on three datasets to verify the effectiveness and robustness of PATN.

Illumination promoting biomass production in wastewater treatment for Rubrivivax gelatinosus

Pan Wu,Xiaohan Xu 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.6

In order to improve the reuse degree of Rubrivivax gelatinosus (R. gelatinosus) resource in soybean producing wastewater (SPW) treatment, the impacts of diverse illumination strength on R. gelatinosus biomass and organic contaminant abatement were discussed. It was reported that with the best illumination strength (6,000 lux), the production (3,800 mg/L) of biomass was increased by sixty percent of dark group. COD removal and protein removal rate got 85 and 80%. Influence of diverse illumination strength on R. gelatinosus growth were divided into three aspects, including illumination limitation (0−5,000 lux), illumination saturation (5,000−7,000 lux), illumination inhibition (8,000 lux or higher). Meanwhile, at 6,000 lux, bacteriochlorophyll and carotenoids contents, ATP production were increased by 200, 200, 43.9% severally. Appropriate illumination improved ATP production by increasing the generation of bacteriochlorophyll and carotenoids in photosynthesis. Augment of energy production provoked the biomass production and wastewater treatment. Nevertheless, low or high illumination strength was un-advantage for R. gelatinosus growth due to the illumination deficiency or restrian. Moreover, 6,000 lux shortened the treatment time from 96 h to 48 h.

Stimulating Effect of a Novel Synthesized Sulfonamido-Based Gallate ZXHA-TC on Primary Osteoblasts

PAN JIN,Li Zheng,Liang Liao,Xiao Lin,Qinggong Guo,Cui-Wu Lin,Huayu Wu,Jinmin Zhao 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.3

Purpose: This study is intended to investigate the effects of plants or plant-derived antioxidants on prevention of osteoporosis through the maintenance of reactive oxygenspecies (ROS) at a favorable level. Materials and Methods: In this study, a novel antioxidant, namely 3,4,5-Trihydroxy-N-[4-(5-hydroxy-6-methoxy-pyrimidin-4-ylsulfamoyl)-phenyl]-benzamide (ZXHA-TC) was synthesized from gallic acid and sulfadimoxine. Its effect on osteoblast metabolism was investigated via the detection of cell proliferation, cell viability, production of ROS, and expression of osteogenic-specific genes including runt-related transcription factor 2 (RUNX2), bone sialoprotein (BSP), osteocalcin (OCN), alpha-1 type I collagen (COL1A1), and osteogenic-related proteins after treatment for 2, 4, and 6 days respectively. Results: The results showed that ZXHA-TC has a stimulating effect on the proliferation and osteogenic differentiation of primary osteoblasts by promoting cell proliferation, cell viability, and the expression of genes BSP and OCN. Productions of bone matrix and mineralization were also increased by ZXHA-TC treatment as a result of up-regulationof COL1A1 and alkaline phosphatase (ALP) at the early stage and down-regulationof both genes subsequently. A range of 6.25×10-3 μg/mL to 6.25×10-1 μg/mL is the recommended dose for ZXHA-TC, within which 6.25×10-2 μg/mL showed the best performance. Conclusion: This study may hold promise for the development of a novel agent for the treatment of osteoporosis.

Sclareol production in the moss Physcomitrella patens and observations on growth and terpenoid biosynthesis

Xi-Wu Pan,Lei Han,Yu-Hua Zhang,Dong-Fang Chen,Henrik Toft Simonsen 한국식물생명공학회 2015 Plant biotechnology reports Vol.9 No.3

The moss Physcomitrella patens was engineered to produce the diterpenoid sclareol, an important precursor for the synthesis of ambergris substitutes for the perfume industry. The best total yield of sclareol was 2.84 mg/g dry weight (2.28 mg/l culture) obtained after 18 days of cultivation in liquid media (extracted from both media and cell pellet). The two active sclareol synthase genes were integrated in a random fashion, and linked with the ribosomal skip 2A under the control of the CaMV 35S promoter. We conclude that moss can produce sclareol and utilize the ribosomal skip 2A. In addition, we observed growth impairment in all our sclareol-producing lines and moss lines knocked out in the endogenous diterpene synthase (copalyl/kaurene synthase—PpCPS/KS). A RT-PCR study, with ubiquitin as the best reference gene, showed that there was a down-regulation of the transcription of the terpenoid biosynthetic genes in the PpCPS/KS knock out moss. This down-regulation was recovered by the introduction of the two sclareol synthases, suggesting that the regulation of the general terpenoid biosynthesis is very flexible and can be amended in future biotechnological engineering.

Genetic variations in DROSHA and DICER and survival of advanced non-small cell lung cancer: a two-stage study in Chinese population

Shuangshuang Wu,Yun Pan,Songyu Cao,Jiali Xu,Yan Liang,Yan Wang,Lei Chen,Yunyan Wei,Chongqi Sun,Weihong Zhao,Zhibin Hu,Hongxia Ma,Hongbing Shen,Jianqing Wu 한국유전학회 2015 Genes & Genomics Vol.37 No.7

MicroRNAs (miRNA) are a class of small, noncoding RNA molecules involved in carcinogenesis. Genetic variations in miRNA processing genes may affect the biogenesis of miRNAs, and consequently affect miRNAs regulation and development and progression of human cancer. Therefore, we hypothesized that polymorphisms in two main miRNA biosynthesis genes (DROSHA and DICER) may modulate the survival of advanced non-small cell lung cancer (NSCLC) patients in China. We selected 36 common tagging SNPs in DROSHA and DICER and evaluated the associations of these SNPs with survival of advanced NSCLC patients by a two-stage study in Chinese Han population (discovery cohort: 303 patients; replication cohort: 340 patients). Thirty-six SNPs were detected in the discovery cohort and 12 promising SNPs were validated in the replication cohort. The results showed that DROSHA rs3805525 was marginally associated with the survival of NSCLC patients in the replication cohort (dominant model: HR 0.69, 95 % CI 0.46–1.03, P = 0.071), which was in the same direction as that in the discovery cohort. When combing all patients into one group, three SNPs (rs3805525, rs17410035 and rs7719497) in DROSHA showed significantly associations with NSCLC survival (additive model: HR 0.82, 95 % CI 0.68–0.99 for rs3805525; HR 0.79, 95 % CI 0.62–1.00 for rs17410035; HR 0.76, 95 % CI 0.62–0.93 for rs7719497). Additionally, the combined analysis of those three SNPs showed a significant locus-dosage effect between number of favorable alleles and death risk of NSCLC (Trend P = 0.002). Genetic variations in DROSHA might be associated with the survival of advanced NSCLC patients in Chinese population.

시스템다이내믹스를 이용한 관광도시의 지속가능한 발전모델에 관한 연구

이판무 ( Li Pan-wu ),문태훈 ( Moon Tae Hoon ) 한국시스템다이내믹스학회 2019 한국시스템다이내믹스 연구 Vol.20 No.3

With increasingly serious urbanization and sharp increase of visitors, environmental pollution problems have arisen in many cities. Especially in tourism cities, these urban problems are serious. In this context, this study aims to explore sustainable development tourism model and find best reasonable set of sustainable policies for tourism cities. For this purpose, this study used System Dynamics Simulation method, building Sustainable Tourism Model for Keifung City, China and conducted extensive simulation experiments. Simulation result shows that environmental, social, and economically coordinated development model that simultaneously increases the ratio of environmental, cultural, and business investment was analyzed as the best sustainable tourism policy. And the unilateral realization of the number of tourists in the tourism city can not achieve the sustainable development of the city, indicating that it needs to coordinate closely with the environment, business and other related departments of the city.

No Room to Move: Public Opinion in Taiwan Offers Few Options on China

Hsin-Hsin Pan,Wen-Chin Wu,Chien-Huei Wu 동아시아재단 2022 Global Asia Vol.17 No.3

從國際法院新判例來重新認識南沙群島主權之爭

반준무 ( Jun Wu Pan ) 제주대학교 법과정책연구소 2015 국제법무 Vol.7 No.1

2009년 초, 필리핀은 황암도와 난사군도의 일부를 필리핀 영해에 속한다고 선포하여 중국의 강력한 반발을 받았고, 난사군도의 주권문제는 다시 세계의 주목을 받게 되었다. 난사군도의 주권문제는 매우 복잡한데, 중국(대만도 포함), 말레시아, 베트남, 필리핀, 브루나이를 포함한 5개 국가가 이에 대한 주권을 주장하고 있는 상황이다. 국제법원을 통하여 난해문제를 해결할 수 있는지에 대하여는 아직 예견할 수는 없으나, 국제법원의 판례를 통하여 난해군도의 주권문제를 법률적으로 분석하는 것은 가능하다. 이 연구를 통하여 분쟁당사자로 하여금 주장의 합법성을 요해하고 분쟁해결의 방식을 제시하고자 한다. 최근 국제법원에서 재판한 Indonesiav. Malaysia 사안은 난사주권분쟁을 다시 인식하고 이에 관한 해결방법을 제시하였다. Although it is still unpredictable for the disputants to submit the disputes over the sovereignty of the Nansha islands (Spratly Islands) to the ICJ, it is possible and even necessary to analyze the disputes based on the case law of the ICJ. The analysis would certainly help the disputants to reassess their claims and legal justifications and hopefully work out a settlement plan. The recent ICJ case of Sovereignth over Pulau Litigan and Pulau Sipadan (Indonesia v. Malaysia) (Indonesia v. Malaysia) embodies many legal implications for settlement of the territorial disputes in the South China Sea.

Design of an Static Reconfiguration Based on FPGA System

Li-hua Wu,Xu-zhang Zhang,Xiao-lei Pan,Meng-yuan Wu 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.2

Aiming at the problem of limited logical resources of FPGA and low rates of internal resource utilization, the design of the static reconfiguration system was introduced in this paper. Based on the structure of CPLD matching FPGA, the static reconfiguration system is able to enhance the scalability of the FPGA device. Major functionality in the static reconfiguration system is accomplishing field reconfiguration of the FPGA device without PC. Users are able to flexibly change the different configuration files in FPGA for that the internal resources of FPGA are occupied by the configuration files of different function at different times. The experimental results showed that the system achieved dynamic switching between different logic function and time division multiplexing of internal resources. The generality of FPGA and the rates of internal resource utilization were improved and the power dissipation was reduced by this design.

High Levels of Malic Acid Production by the Bioconversion of Corn Straw Hydrolyte Using an Isolated Rhizopus Delemar Strain

Xingjiang Li,Ya Liu,Ying Yang,Hua Zhang,Hualin Wang,Yue Wu,Min Zhang,Ting Sun,Jieshun Cheng,Xuefeng Wu,Lijun Pan,Shaotong Jiang,Hongwei Wu 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.3

The microbial fermentation of malic acid,which is one of the most important organic acid platformsused widely in food and chemical engineering, hasattracted considerable interest. A malate production strainwas isolated, a mutation was induced, and regulation of themetabolic network was then conducted. The identificationresults showed that the malic acid production strain, HF-119, belonged to Rhizopus delemar. An analysis of themetabolic pathway showed that the malic acid flux of thisstrain occurred through three main pathways, and manybyproducts, such as succinic acid, fumaric acid andethanol, were produced. Although corn straw hydrolytewas used, the metabolism of xylose was not as rapid as thatof glucose. Subsequently, breeding of the strains andregulation of the metabolic network resulted in an increasein malate yield, and the strain HF-121 produced more than120 g/L malic acid within 60 h. The ability to producemalic acid from biomass hydrolyte highlights the industrialdevelopment potential of this strain.