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- 저자 : Weiqi Zheng (검색결과 3 건)
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Weiqi Zheng,Xingwang Sheng,Zhihui Zhu,Tao Shi 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.80 No.2
Laying ballastless tracks on large-span cable-stayed bridge is a new challenge, and it is particularly important due to the obvious advantages of ballastless track and the high requirements of high-speed railways. Under the complex load conditions in service, cable-stayed bridges have a variety of beam local deformations, and they inevitably affect the performances of the ballastless tracks laid on the bridge. In this work, a series of experimental studies and FEM simulations are carried out based on a large-span cable-stayed bridge and its segmental model. The main conclusions include: Under the most unfavorable reverse bending deformation of the large-span cable-stayed bridge, tensile and compressive deformations occurred at interlayers of the ballastless tracks with different isolation layers. The interlayer deformation variations of the ballastless tracks with EPDM or geotextile isolation layers are the same, and the deformation values of the ballastless tracks with EPDM isolation layers are larger than that of the ballastless tracks with geotextile isolation layers. However, due to the pre-compression of the EPDM isolation layer subjected to its upper structures’ deadweight, it can reduce the influences of the reverse bending deformation on the ballastless tracks, and the gaps and voids at ballastless track interlayers can be avoided. Furthermore, the 5.92 m length ballastless tracks with EPDM isolation layer is recommended to apply on the large-span cable-stayed bridge in high-speed railway to ensure the reliability and durability of the ballastless tracks.
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Yiling Zheng,Liming Wang,Fan Wu,Weiqi Rong,Yunhe Liu,Kai Zhang,Jianxiong Wu 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.98 No.5
Purpose: To evaluate the safety and effectiveness of an enhanced recovery after surgery (ERAS) programme after curative liver resection in cirrhotic hepatocellular carcinoma (HCC) patients. Methods: One hundred sixty-two patients were enrolled in the study; 80 patients whose data were collected prospectively were assigned to the ERAS group, and 82 patients whose data were collected retrospectively were assigned to the control group. Preoperative clinicopathologic factors, surgical factors, and postoperative outcomes of the 2 groups were compared. Logistic regression was applied to explore potential predictors of hospital stay and morbidity. Results: The postoperative hospital stay, postoperative complication rate, and recovery of liver function on postoperative day 5 seemed to be better in the ERAS group. The composition of complications was different in the 2 groups; pleural effusion and postoperative ascites were more common in the control group, and indocyanine green retention at 15 minutes, operation time, preoperative alanine aminotransferase, and number of liver segmentectomies were associated with postoperative complications rather than ERAS intervention. Conclusion: The ERAS programme is safe and effective for HCC patients with chronic liver disease undergoing hepatectomy, but it seems that surgical factors, such as operation type, have a greater impact on morbidity than other factors. Operative characteristics such as the method of blood loss control and the volume of liver resection should be augmented into ERAS protocol of hepatectomy.
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Vasodilation Effect of 2-benzyl-5-hydroxy-6-methoxy-3, 4-dihydroisoquinolin- 1-one
Wei-Qi,Yong-Xiao Cao,Zhi-Zheng Xiong,Ting-Ting Chen,Xiao-Yan Gao,Hang Yu,San-Qi Zhang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.8
A 2-Benzyl-5-hydroxy-6-methoxy-3, 4-dihydroisoquinolin-1-one (ZC2) is a newly synthesized isoquinolinone compound. Its effect on vasodilation was evaluated in the present study. Isometric tension of rat artery rings was recorded by a sensitive myography system in vitro. The results showed that ZC2 relaxed rat mesenteric arteries pre-contracted by KCl, phenylephrine and 9, 11- dideoxy- 11α, 9α-epoxymethano-prostaglandin F2α (U46619), and abdominal aorta pre-contracted by KCl in a concentration-dependent manner. The ZC2-induced vasodilation was not affected by an endothelium denudation. ZC2 rightwards shifted the concentration-contraction curves, induced by KCl, phenylephrine, and 5-hydroxytryptamine (5-HT) in a non-parallel manner, which suggests that the vasodilation effects are most likely via voltage-dependent calcium channel (VDCC) and receptor-operated calcium channel (ROCC). Moreover, in Ca2+-free medium, ZC2 concentration-dependently depressed the vasoconstrictions induced by phenylephrine and CaCl2, and decreased a contractile response induced by caffeine, which indicates a role of extracellular Ca2+ influx inhibition through VDCC and ROCC, and intracellular Ca2+ release from Ca2+ store via the ryanodine receptors. Glibenclamide did not affect the vasodilation induced by ZC2, suggesting that ATP sensitive potassium channel is not involved in the vasodilation. The results indicate that ZC2 induces vasodilation by inhibiting the VDCC and ROCC, and receptormediated Ca2+ influx and release. The inhibition of intracellular Ca2+ release may be mediated via the ryanodine receptors.
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