A Short Review on the Chemistry, Pharmacological Properties and Patents of Obovatol and Obovatal (Neolignans) from Magnolia obovata

Eric Wei Chiang Chan,Siu Kuin Wong,Hung Tuck Chan 한국생약학회 2021 Natural Product Sciences Vol.27 No.3

This short review on the chemistry, pharmacological properties and patents of obovatol and obovatal from Magnolia obovata is the first publication. Pharmacological properties are focused on anti-cancer, anti-inflammatory, anti-platelet and neuroprotective activities. Obovatol and obovatal were first isolated from the leaves of M. obovata. Also reported in the bark and fruits of M. obovata, obovatol and obovatal are neolignans i.e., biphenolic compounds bearing a C‒O coupling. Other classes of compounds isolated and identified from M. obovata include sesquiterpene-neolignans, dineolignans, trineolignan, lignans, dilignans, phenylpropanoids, phenylethanoid glycosides, flavonoids, phenolic acids, alkaloids, sesquiterpenes, ketone and sterols. The anti-cancer properties of obovatol and obovatal involve apoptosis, inhibition of the growth, migration and invasion of cancer cell lines. However, obovatol displays cytotoxicity against cancer cells but not obovatal. Similarly, anti-inflammatory, anti-platelet, neuroprotective, anxiolytic and other pharmacological activities were only observed in obovatol. The disparity in pharmacological properties of obovatol and obovatal may be attributed to the ‒CHO group present in obovatal but absent in obovatol. From 2007 to 2013, eight patents were published on obovatol with one mentioning obovatal. They were all published at the U.S. Patent and Trademark Office by scientists of the Korea Research Institute of Bioscience and Biotechnology (KRIBB) as inventors and assignee, respectively. Some future research and prospects are suggested.

Explaining the DAMPE <tex> $ e^{+}e^{-}$</tex> excess using the Higgs triplet model with a vector dark matter

Chen, Chuan-Hung,Chiang, Cheng-Wei,Nomura, Takaaki American Physical Society 2018 Physical Review D Vol.97 No.6

Chemical Synthesis and Annealing Procedures of FePt Nanoparticles

D. H. Wei,D. S. Hung,P. C. Chiang,J. W. Wang,C. S. Ho,Y. D. Yao 한국자기학회 2007 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-

Activated carbon@MgO@Fe3O4 as an efficient adsorbent for As (III) removal

Esmaeili Hossein,Mousavi Seyyed Mojtaba,Hashemi Seyyed Alireza,Chiang Wei-Hung,Ahmadpour Abnavi Somayeh 한국탄소학회 2021 Carbon Letters Vol.31 No.5

In this study, Fe3O4/MgO/Activated carbon composite was used to remove arsenic ion (As (III)) from aqueous media. To this end, Frangula Alnus was used to prepare activated carbon (AC) by calcination in the furnace at 700 °C for 4 h and was then used to synthesize the MgO/Fe3O4/AC composite. To study the surface properties of the composite, various analyses such as SEM, EDX/Mapping, FTIR, DLS, BET and VSM were applied. According to the BET analysis, the specifc surface area and average pore size of the Fe3O4/MgO/AC composite were obtained as 190.92 m2 /g and 7.57 nm, respectively, which showed that the aforementioned nanocomposite had a mesoporos structure with an excellent specifc surface area. Also, VSM analysis indicated that the composite had a superparamagnetic property and could be easily separated from the solution by a magnet. Moreover, the results of the As (III) sorption indicated that the highest uptake efciency was obtained 96.65% at pH=7, adsorbent dosage=0.13 g/L, t=35 min, T=45 °C and Co=6 mg/L. In addition, the pseudo-second-order model could better describe the kinetic behavior of the sorption process. Furthermore, Langmuir model was the best model to describe the equilibroium behavior of the As(III) ion sorption. Besides, according to the the thermodynamic study, enthalpy change and entropy change were obtained 58.11 kJ/mol and 224.49 J/mol.K, respectively, indicating that the sorption process was spontaneous and endothermic. According to the results, the Fe3O4/MgO/AC composite was a good adsorbent with the extraordinary properties, which can be used on an industrial scale.

Synergistic effect of metal-organic framework-derived boron and nitrogen heteroatom-doped three-dimensional porous carbons for precious-metal-free catalytic reduction of nitroarenes

Van Nguyen, Chi,Lee, Seulchan,Chung, Yongchul G.,Chiang, Wei-Hung,Wu, Kevin C.-W. Elsevier 2019 Applied Catalysis B Vol.257 No.-

<P><B>Abstract</B></P> <P>We report a scalable and controllable synthesis of metal-organic framework (MOF)-derived three-dimensional boron and nitrogen heteroatom-doped porous carbons (3D-BNPCs) and their synergistic effect for metal-free catalytic 4-nitrophenol (4-NP) reduction. The substitution of boron atoms into zeolitic imidazole framework-8 (ZIF-8)-derived nitrogen-doped porous carbon (B-NPC-1200) significantly improves the electrical conductivity and the catalytic 4-NP reduction. We propose the heteroatom-doping of boron, nitrogen and oxygen in the 3D- B-N PC catalysts creates synergistic effect on 4-NP reduction by creating more catalytically active sites. High-Resolution X-ray Photoelectron Spectroscopy (HR-XPS) and Density Functional Theory (DFT) calculations were carried out to confirm and investigate the role of active sites on adsorption of 4-NP molecules in B-NPC-1200. We find that the strongly active sites can only be created based on the synergistic effect between nitrogen, boron and oxygen atoms, and the increased density of the active sites are responsible for the lowering of the apparent activation energy in B-NPC-1200 structure. As synthesized B-NPC-1200 exhibits superior catalytic activities for 4-NP reduction with a low apparent activation energy of 27.0 kJ/mol and a high reaction rate constant of 2.3*10^<SUP>−3</SUP> (s<SUP>-1</SUP>). The catalyst can run five times without decreasing significant catalytic activity. The reduction reactions of various nitroarene compounds have been further tested using the B-N PC-1200 material as the precious-metal-free catalyst.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ZIF-derived boron- and nitrogen-co-doped 3-dimensional porous carbon (3D-BNPC) is synthesized for the first time. </LI> <LI> The 3D-NPC shows uniform morphology and extremely high surface area. </LI> <LI> The 3D-NPC catalyst exhibits superior activity for 4-nitrophenol (4-NP) reduction into 4-aminophenol (4-AP). </LI> <LI> Density functional theory (DFT) calculation is studied. </LI> <LI> The co-doping of B with N in the 3D-BNPC catalysts provides the synergistic effect on 4-NP reduction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Shape-controlled synthesis of zinc nanostructures mediating macromolecules for biomedical applications

Seyyed Mojtaba Mousavi,Gity Behbudi,Ahmad Gholami,Seyyed Alireza Hashemi,Zohre Mousavi Nejad,Sonia Bahrani,Wei-Hung Chiang,Lai Chin Wei,Navid Omidifar 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1

Zinc nanostructures (ZnONSs) have attracted much attention due to their morphological, physicochemical, and electrical properties, which were entailed for various biomedical applications such as cancer and diabetes treatment, anti-inflammatory activity, drug delivery. ZnONS play an important role in inducing cellular apoptosis, triggering excess reactive oxygen species (ROS) production, and releasing zinc ions due to their inherent nature and specific shape. Therefore, several new synthetic organometallic method has been developed to prepare ZnO crystalline nanostructures with controlled size and shape. Zinc oxide nanostructures’ crystal size and shape can be controlled by simply changing the physical synthesis condition such as microwave irradiation time, reaction temperature, and TEA concentration at reflux. Physicochemical properties which are determined by the shape and size of ZnO nanostructures, directly affect their biological applications. These nanostructures can decompose the cell membrane and accumulate in the cytoplasm, which leads to apoptosis or cell death. In this study, we reviewed the various synthesis methods which affect the nano shapes of zinc particles, and physicochemical properties of zinc nanostructures that determined the shape of zinc nanomaterials. Also, we mentioned some macromolecules that controlled their physicochemical properties in a green and biological approaches. In addition, we present the recent progress of ZnONSs in the biomedical fields, which will help centralize biomedical fields and assist their future research development.