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Yunxiang Zang,Hao Zhang,Linghui Huang,Fang Wang,Fei Gao,Xishan Lv,Jing Yang,Biao Zhu,홍승범,Zhujun Zhu 한국원예학회 2015 Horticulture, Environment, and Biotechnology Vol.56 No.6
Glucosinolates have attracted considerable attention in the past several decades because of their involvement in pathogen and insect resistance of Brassicaceae as well as anti-inflammatory and anti-oxidation activity in humans. Methyl jasmonate (MeJA) treatment generally increases the levels of indole and aromatic glucosinolates; however, the time course of MeJA effects on the levels of individual glucosinolates in different pak choi cultivars has not been studied. Here, we found that foliar MeJA application increased accumulation of indole glucosinolates in both leaves and roots of four cultivars. However, roots accumulated much higher levels of indole glucosinolates and, compared to leaves, showed a delayed response to MeJA in terms of indole glucosinolate accumulation in all four cultivars. Individual indole glucosinolate levels in roots differed depending on the sampling time in different cultivars. The level of neoglucobrassicin steadily increased over 72 h. Glucobrassicin was induced in leaves of SHQ and HZYDE, and in roots of three cultivars, whereas 4-methoxyglucobrassicin was induced only in roots. Aromatic glucosinolate enrichment occurred only in roots. Aliphatic glucosinolates were detected only in the leaves but not in roots, accumulating to comparable levels as in untreated controls. These results suggest that exogenous MeJA-mediated signal transduction did not immediately lead to biosynthesis of aliphatic and aromatic glucosinolates but did induce increased accumulation of indole glucosinolates in pak choi. Individual glucosinolate accumulation profiles were different depending oncultivars.
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Lin Peiyu,Yang Xiyue,Wang Linghui,Zou Xin,Mu Lingli,Xu Cangcang,Yang Xiaoping 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.3
Bladder cancer remains the 10th most common cancer worldwide. In recent years, metformin has been found to have potential anti-bladder cancer activity while high concentration of IC50 at millimolar level is needed, which could not be reached by regular oral administration route. Thus, higher efficient agent is urgently demanded for clinically treating bladder cancer. Here, by conjugating artesunate to metformin, a novel artesunate-metformin dimer triazine derivative AM2 was designed and synthesized. The inhibitory effect of AM2 on bladder cancer cell line T24 and the mechanism underlying was determined. Anti-tumor activity of AM2 was assessed by MTT, cloning formation and wound healing assays. Decreasing effect of AM2 on lipogenesis was determined by oil red O staining. The protein expressions of Clusterin, SREBP1 and FASN in T24 cells were evaluated by Western blotting. The results show that AM2 significantly inhibited cell proliferation and migration at micromolar level, much higher than parental metformin. AM2 reduced lipogenesis and down-regulated the expressions of Clusterin, SREBP1 and FASN. These results suggest that AM2 inhibits the growth of bladder cancer cells T24 by inhibiting cellular lipogenesis associated with the Clusterin/SREBP1/FASN signaling pathway.
ScienceON
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