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Vo Thuy-Trang T.,Kong Gyeyeong,Kim Chaeyeong,Juang Uijin,Gwon Suhwan,Jung Woohyeong,Nguyen Huonggiang,Kim Seon-Hwan,Park Jongsun 한국독성학회 2023 Toxicological Research Vol.39 No.3
Scavenger Receptor Class F Member 2 (SCARF2), also known as the Type F Scavenger Receptor Family gene, encodes for Scavenger Receptor Expressed by Endothelial Cells 2 (SREC-II). This protein is a crucial component of the scavenger receptor family and is vital in protecting mammals from infectious diseases. Although research on SCARF2 is limited, mutations in this protein have been shown to cause skeletal abnormalities in both SCARF2-deficient mice and individuals with Van den Ende-Gupta syndrome (VDEGS), which is also associated with SCARF2 mutations. In contrast, other scavenger receptors have demonstrated versatile responses and have been found to aid in pathogen elimination, lipid transportation, intracellular cargo transportation, and work in tandem with various coreceptors. This review will concentrate on recent progress in comprehending SCARF2 and the functions played by members of the Scavenger Receptor Family in pre-diagnostic diseases.
AXL is required for hypoxia-mediated hypoxia-inducible factor-1 alpha function in glioblastoma
Vo Thuy-Trang T.,Tran Quangdon,Hong Youngeun,Lee Hyunji,Cho Hyeonjeong,Kim Minhee,Park Sungjin,Kim Chaeyeong,Bayarmunkh Choinyam,Boldbaatar Damdindorj,Kwon So Hee,Park Jisoo,Kim Seon-Hwan,Park Jongsun 한국독성학회 2023 Toxicological Research Vol.39 No.4
Glioblastoma (GBM) is the most aggressive type of central nervous system tumor. Molecular targeting may be important when developing efficient GBM treatment strategies. Sequencing of GBMs revealed that the receptor tyrosine kinase (RTK)/ RAS/phosphatidylinositol-3-kinase pathway was altered in 88% of samples. Interestingly, AXL, a member of RTK, was proposed as a promising target in glioma therapy. However, the molecular mechanism of AXL modulation of GBM genesis and proliferation is still unclear. In this study, we investigated the expression and localization of hypoxia-inducible factor-1 alpha (HIF-1α) by AXL in GBM. Both AXL mRNA and protein are overexpressed in GBM. Short-interfering RNA knockdown of AXL in U251-MG cells reduced viability and migration. However, serum withdrawal reduced AXL expression, abolishing the effect on viability. AXL is also involved in hypoxia regulation. In hypoxic conditions, the reduction of AXL decreased the level and nuclear localization of HIF-1α. The co-expression of HIF-1α and AXL was found in human GBM samples but not normal tissue. This finding suggests a mechanism for GBM proliferation and indicates that targeting AXL may be a potential GBM therapeutic.
Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma
Kim Chaeyeong,Kong Gyeyeong,Lee Hyunji,Tran Quangdon,Vo Thuy-Trang T.,Kwon So Hee,Park Jisoo,Kim Seon-Hwan,Park Jongsun 한국독성학회 2022 Toxicological Research Vol.38 No.2
Scavenger receptor class F member 2 (SCARF2) is expressed by endothelial cells with very large cytoplasmic domains and is the second isotype, also known as scavenger receptor expressed by endothelial cells 2 (SREC-2). SREC-1 plays an important role in the binding and endocytosis of various endogenous and exogenous ligands. Many studies have been carried out on modified low-density lipoprotein internalization activity, but there have been few studies on SCARF2. Higher expression of SCARF2 has been found in glioblastoma (GBM) than normal brain tissue. Through analysis of The Cancer Genome Atlas database, it was confirmed that SCARF2 is widely expressed in GBM, and increased SCARF2 expression correlated with a poor prognosis in patients with glioma. The results of this study showed that the expression of SCARF2 is increased in GBM cell lines and patients, suggesting that SCARF2 may be a potential diagnostic marker and therapeutic molecule for cancers including glioma.