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- 저자 : U.V. Mani (검색결과 1 건)
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Hypocholesterolemic Effect of Spirulina in Patients with Hyperlipidemic Nephrotic Syndrome
U.V. Mani,R. Samuels,U.M. Iyer,U.S. Nayak 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.2
In nephrotic syndrome, large amounts of plasma proteins are lost in urine, causing a decreasein the plasma oncotic pressure. This leads to enhanced hepatic synthesis of albumin and otherproteins, including lipoproteins, causing a secondary hyperlipidemia. Essential fatty acidssuch as g-linolenic acid (GLA) can prevent accumulation of cholesterol in the body, and spir-ulina has an apreciable amount of GLA. In this study 23 patients (age 2 to 13 years) withnephrotic syndrome received either medication (group I) or medication plus 1 g/day Spirulina(group II). Height, weight, and serum levels of fasting blood sugar, triglycerides, total cho-lesterol (TC), and low- and high-density cholesterol fractions (LDL-C and HDL-C, respec-tively) were measured before and after the 2-month study period. Mean height and weightwere normal compared with healthy, age-matched Indian children. Lipoprotein cholesterollevels were significantly increased at baseline. TC significantly decreased by 16.33 mg/dl,LDL-C by 94.14 mg/dl, and triglycerides by 67.72 mg/dl in group II; in control group I, thesevalues fell by 69.87, 61.13, and 2.62 mg/dl, respectively. The LDL-C:HDL-C ratio also de-creased significantly, by 1.66 in group II and 1.13 in group I. TC:HDL-C decreased by 1.96 ingroup II and 1.19 in group I. HDL-C:LDL-C also improved significantly in both the groups.It can be concluded that spray-dried Spirulina capsules, rich in antioxidants, GLA, aminoacids, and fatty acids, helped reduce the increased levels of lipids in patients with hyper-lipidemic nephrotic syndrome.91
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