http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Tushuai Li (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Tushuai Li,Li Chen,Xiao Fu,Zhihong Liu,Shenglong Zhu,Yongquan Chen,Jie Zhang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.112 No.-
Chemodynamic therapy (CDT) based on multifunctional nanoparticles (NPs) has occurred as an attractivecancer treatment that covers the shortage of nonnegligible limitations from single therapy. Herein, wesynthesize a safe and universal CDT nanoparticle—iron single-atom nanoparticle (Fe SANP), in whichFe single-atom as the active catalytic site is anchored in a carbon framework with encapsulated doxorubicin(DOX). Fe SANPs work as catalase-like nanozyme for hydroxyl radicals (OH) production. The preparedNPs (denoted as DOX@Fe SANPs) can efficiently mediate peroxidase-like activity with the existenceof H2O2 that enhances cancer cell elimination by generating abundant OH. DOX@Fe SANPs exhibit a pHinduceddegradable character that contributes to specific drug release in the tumor microenvironment(TME). DOX@Fe SANPs produce ignorable systematic toxicity after biodegradation and drug delivery processes. Collectively, this study highlights the efficient anti-tumor performances of the iron single-atomnanocatalysts containing an anti-cancer drug DOX.
-
Manganese single-atom nanostructures for highly efficient tumor therapy
Jiaping Pei,Hui Dou,Chencai Liu,Tushuai Li 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-
The single-atom attracts growing interests in various fields and provides a new strategy for tumor therapyby inspiring chemodynamic-photothermal therapy (CPT) effects owing to its excellent catalytic properties. We synthesize the Folic acid@single atomic manganese (Mn) nanoparticles (FA@SAMn NPs) withmesoporous carbon sphere structure by the coordination aided polymerization assembly method. Antitumor therapeutic effect studies were carried out in vitro and in vivo. This hierarchical nanostructurepossesses a high surface area, large pore, and rich N that provide higher catalytic activity, and it also exhibitsexcellent activity and stability in the oxygen reduction reaction. With its accumulation in the specifictumor microenvironment, the FA@SAMn NPs could generate reactive oxygen species (ROS), which wouldmediate a series of 4 T1 cell damage and inhibit tumor propagation (56% mortality rate). Moreover, theFA@SAMn NPs possess an excellent photothermal effect under near infrared-II (NIR-II) laser irradiation. This leads to a local hyperthermia situation in the tumor area and contributes to tumor inhibition (91%mortality rate). In sum, FA@SAMn catalysts effectively suppressed tumor growth and significantlyincreased the survival time. This work aims to provide new potential single-atom-coordinated carbonnetworks that possess efficient biocatalytic sites and photothermal effects, inspiring a series of advancesin ROS and photothermal-related biological applications across broad biomedical fields.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
