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Chemical Constituents from the Aerial Parts of Bupleurum falcatum L. and Biological Evidences
Nguyen Huu Tung,Takuhiro Uto,Osamu Morinaga,Yukihiro Shoyama 한국생약학회 2015 Natural Product Sciences Vol.21 No.2
In this study, phytochemical investigation on the aerial parts of Bupleurum falcatum resulted in the isolation of fourteen compounds including three quinic acid derivatives (1 - 3), five flavonoids (4 - 8), three monoterpene glycosides (9 - 11), and three saikosaponins (12 - 14). Compound 1 was first isolated from nature and unambiguously determined to be 3-O-feruloyl 5-O-caffeoylquinic acid on the basis of the extensive spectroscopic evidence. Biological testing revealed that saikosaponin A (12) and saikosaponin D (13) showed moderate anti-proliferative effects on HL-60 and HepG2 cancer cell lines.