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Sungwoo Cho 순천향대학교 순천향의학연구소 2018 Journal of Soonchunhyang Medical Science Vol.24 No.2
Objective: A tablet device has several medical applications because it’s portability. Most importantly, its powerful graphics and touch-based features have several benefits in the surgical field, especially for generating three-dimensional (3D) images based on patients’ computed tomography (CT) scans. Methods: In this study, 3D objects were manipulated by an operator on an iPad during several laparoscopic surgeries of intra-abdominal organs. Before surgery, 3D structures, such as vessels, soft tissues, and bones, were reconstructed by the surgeon using the patients’ CT scans on the patients’ bed-side personal computer. Results: In this study, 3D image-guided surgeries were performed using an iPad in five patients. The benefits of this technique were recorded and analyzed in detail by the surgeon. Conclusion: Although in a pilot phase with unresolved issues, direct intra-operative handling of a patient-tailored 3D model developed using a tablet device could be useful compared with conventional two-dimensional imaging.
Sungwoo CHO,Boram SON,Tai Hyun PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Cells can ‘feel’ the physical cues and ‘respond’ by changing their function. In the mechanotransduction field, the conventional hypothesis is that physical properties, such as stiffness and ligand distance of the matrix are influencing the differentiation of stem cells. In this study, we hypothesized that the key factor of previous studies is the force, tension, applied to the cell. A system that could exert magnetic force to cells by external magnetic field was established, resulting in the following. First, intracellular magnetic nanoparticles (MNPs)’ properties, such as quantity and cytotoxicity were analyzed. Second, the osteogenic marker genes (COL-1, OPN, and OCN) expression level were increased statistically significantly in proportion to the strength of the magnetic force. Third, ALP, ARS staining, and osteogenic marker protein (OPN and OCN) staining showed the osteogenic function of cells and upregulated protein expression of the tension-applied group. Further, applying tension triggers transcription factor, YAP and RUNX2, translocation from the cytoplasm to the nucleus. Finally, the signaling pathway was analyzed by Western blot image. The MAPK/ERK pathway was activated in the hMSCs exposed to magnetic forces. Through this study, we could find the key factor of mechanotransduction and regulate osteogenic differentiation of stem cells.