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Beneficial effects of cannabidiol from Cannabis
Lee Sullim,Lee Yunjeong,Kim Yunseo,Kim Hyunji,Rhyu Haerim,Yoon Kyoungmi,Lee Chang-Dae,Lee Sanghyun 한국응용생명화학회 2024 Applied Biological Chemistry (Appl Biol Chem) Vol.67 No.-
Cannabis, traditionally used for recreation due to psychoactive compounds in its leaves, flowers, and seeds, has not been thoroughly explored for potential therapeutic benefits. Δ9-trans-Tetrahydrocannabinol, a key cannabinoid in cannabis, causes hallucinogenic effects and delirium symptoms. In contrast, cannabidiol (CBD) does not induce hallucinations and has shown effectiveness in treating symptoms of various rare, incurable diseases. Cannabis exhibits neuroprotective, anti-inflammatory, anti-thrombotic, anti-bacterial, analgesic, and antiepileptic properties, recently attracting more attention. This review aims to summarize comprehensively the impact of cannabis on human health, focusing on endocannabinoids and their receptors. It also delves into recent CBD research advancements, highlighting the compound’s potential medical applications. Overall, this paper provides valuable insights into the prospective development of medical cannabis, with a particular emphasis on CBD.
Lee, Ah Young,Lee, Sullim,Kim, Hyun Young,Lee, Sanghyun,Cho, Eun Ju The Korean Society for Applied Biological Chemistr 2016 Applied Biological Chemistry (Appl Biol Chem) Vol.59 No.5
The effects of luteolin (LT) and luteoloside (LS) from Taraxacum coreanum, using lipopolysaccharide (LPS)/interferon-gamma (IFN-${\gamma}$)-induced RAW264.7 macrophage cells, on anti-inflammation were investigated. Our study was focused on the ethyl acetate fraction from T. coreanum (ETC) and its active compounds and their protective role against inflammation. The ETC and its active compounds, LT and LS, showed dose-dependent inhibitory activity against the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS/IFN-${\gamma}$-stimulated RAW264.7 cells. In addition, ETC and its active compounds inactivated nuclear factor-kappa B and down-regulated inflammatory mediators. The results also showed that treatment with ETC, LT, and LS decrease pro-inflammatory cytokines, tumor necrosis factor-alpha, and interleukin-6. In conclusion, our studies indicated that ETC has anti-inflammatory activity owing to inhibition of NO/ROS generation and down-regulation of inflammatory mediators and cytokines. Moreover, LT and LS are bioactive compounds of ETC with protective effects against inflammation.
Lee, Sullim,Lee, Da-Hye,Kim, Jin-Chul,Um, Byung Hun,Sung, Sang Hyun,Jeong, Lak Shin,Kim, Yong Kee,Kim, Su-Nam Academic Press 2017 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Pectolinarin and pectolinarigenin have been reported to be major compounds in <I>Cirsium setidens</I>. In the present study, we demonstrated inhibitory effects of pectolinarin and pectolinarigenin from <I>C. setidens</I> on melanogenesis. Melanin synthesis was decreased in both pectolinarin- and pectolinarigenin-treated melan-a cells and in a reconstructed human skin model. However, pectolinarigenin treatment showed more potent inhibitory activity of melanin synthesis than did pectolinarin treatment. The concentrations of pectolinarin and pectolinarigenin in <I>C. setidens</I> water extracts were determined by HPLC. Unfortunately, the amount of pectolinarigenin of <I>C. setidens</I> water extract was lower than that of pectolinarin. To increase the pectolinarigenin content in <I>C. setidens</I> water extract, several component conversion methods were studied. Consequently, we identified that microwave irradiation under 1% acetic acid was an optimum sugar elimination method.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pectolinarigenin has more potent inhibitory effects than pectolinarin on melanin synthesis in melan-a cells. </LI> <LI> Pectolinarigenin has more potent inhibitory effects than pectolinarin on expression of melanogenesis-related genes. </LI> <LI> Pectolinarigenin has inhibitory effect on melanin production in a reconstructed human skin model. </LI> <LI> Microwave irradiation under 1% acetic acid conditions is optimal to convert pectolinarin into pectolinarigenin. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>