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SUH, Kwang Sik,NAM, Yeon Ho,AHN, Young Min,KIM, Nam Jae,PARK, Cheol Young,KOH, Gwanpyo,OH, Seungjoon,WOO, Jeong Taek,KIM, Sung Woon,KIM, Jin Woo,KIM, Young Seol WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
Endothelial cell apoptosis has been postulated as the initial trigger of the progression of progression disease in patients with diabetes mellitus. To investigate the role of Scutellariae radix extract, we examined its effect on the endothelial cell proliferation using the [(3)^H]-thymidine incorporation method. Scutellariae radix extract significantly stimulated endothelial cell proliferation in a dose-dependent manner. We focused on the protective action of Scutellariae radix extract on the endothelial tell apoptosis induced by high glucose concentrations. Determination of endothelial cell apoptosis was performed using DNA gel electrophoresis, terminal deoxynuclotidyl transferase-mediated dUTP nick end-labeling(TUNEL) assay, and an ELISA kit. Exposure of vascular endothelial cell to high glucose (16.7mM) for 72h resulted in a significant increase in apoptosis, compared with the normal glucose concentrations (5.5mM). Scutellariae radix extract inhibited high glucose-induced endothelial cell apoptosis. This result suggests that Scutellariae radix extract may contribute to antiapoptotic action against vascular endothelial cells, resulting in a beneficial effect in preventing diabetes-associated microvascular complications.
Sung, lel-Yong,Son, Jang-Ho,Ryu, Sung-Ho,Seo, Jae-Hee,Kim, Sung-Sook,Choi, In-Pyo,Ryu, Sung-Ho,Suh, Pann-Ghill,Byeon, Ki-Jeong 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2
Cyclosporine-A(CsA)는 이식 장기의 면역거부반응을 억제하고 또한 면역학적으로 이상이 있는 여러 질병의 치료제로 널리 시용된다. CsA는 세포 매개성 면역시스템의 변환에 중요한 역할을 하지만 몇가지 T-림프구 유도 사이토카인의 방출을 억제하여 간접적으로 단핵구의 기능에도 영향을 미친다. CsA는 치은 과증식을 포함한 많은 CsA유도 치은 과증식증의 병인론에 대해서는 아직 완전히 밝혀지지 않았다. 저자들은 CsA와 을 함계 사용한 4명의 신장 이식 환자에서 치은 형질세포 육아종을 interleukin-6 을 이용한 면역조각화학볍으로 분석하였다. 비록 약물성 유도성 치은 과식증의 병인론은 불분명하지만,CsA가 여러 성장인자(growth factor)와 platelet-derived growth factors-B(PDGF-B) 및 interleukin-6에 작용하여 섬유모세포의 활동성을 변화시킨다고 여겨진다.
Degrees of Freedom of the Rank-Deficient Interference Channel With Feedback
Sung Ho Chae,Changho Suh,Sae-Young Chung IEEE 2015 IEEE transactions on information theory Vol.61 No.6
<P>We study the sum degrees of freedom (DoFs) of the K-user rank-deficient interference channel with feedback. For the two-user case, we characterize the sum DoF by developing an achievable scheme and deriving a matching upper bound. For the three-user case, we develop a new achievable scheme which employs interference alignment to efficiently utilize the dimension of the received signal space. In addition, we derive an upper bound for the general K-user case and show the tightness of the bound when the number of antennas at each node is sufficiently large. As a consequence of these results, we show that feedback can increase the DoF when the number of antennas at each node is large enough as compared with the ranks of channel matrices. This finding is in contrast to the full-rank interference channel where feedback provides no DoF gain. The gain comes from using feedback to provide alternative signal paths, thereby effectively increasing the ranks of desired channel matrices.</P>