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Lee, B.C.,Kim, M.S.,Pae, M.,Yamamoto, Y.,Eberle, D.,Shimada, T.,Kamei, N.,Park, H.S.,Sasorith, S.,Woo, J.,You, J.,Mosher, W.,Brady, Hugh J.M.,Shoelson, Steven E.,Lee, J. Cell Press 2016 Cell metabolism Vol.23 No.4
<P>Obesity-induced inflammation mediated by immune cells in adipose tissue appears to participate in the pathogenesis of insulin resistance. We show that natural killer (NK) cells in adipose tissue play an important role. High-fat diet (HFD) increases NK cell numbers and the production of proinflammatory cytokines, notably TNF alpha, in epididymal, but not subcutaneous, fat depots. When NK cells were depleted either with neutralizing antibodies or genetic ablation in E4bp4(+/-) mice, obesity-induced insulin resistance improved in parallel with decreases in both adipose tissue macrophage (ATM) numbers, and ATM and adipose tissue inflammation. Conversely, expansion of NK cells following IL-15 administration or reconstitution of NK cells into E4bp4(-/-) mice increased both ATM numbers and adipose tissue inflammation and exacerbated HFD-induced insulin resistance. These results indicate that adipose NK cells control ATMs as an upstream regulator potentially by producing proinflammatory mediators, including TNF alpha, and thereby contribute to the development of obesity-induced insulin resistance.</P>
A Novel Optimization-Based Approach for Minimum Power Multicast in Wireless Networks
Yen, Hong-Hsu,Lee, Steven S.W.,Yap, Florence G.H. The Korea Institute of Information and Commucation 2011 Journal of communications and networks Vol.13 No.1
In this paper, we formulate the minimum power multicast problem in wireless networks as a mixed integer linear programming problem and then propose a Lagrangean relaxation based algorithm to solve this problem. By leveraging on the information from the Lagrangean multiplier, we could construct more power efficient routing paths. Numerical results demonstrate that the proposed approach outperforms the existing approaches for broadcast, multicast, and unicast communications.
A Novel Optimization-Based Approach for Minimum Power Multicast in Wireless Networks
Hong-Hsu Yen,Steven S. W. Lee,Florence G. H. Yap 한국통신학회 2011 Journal of communications and networks Vol.13 No.1
In this paper, we formulate theminimumpowermulticast problem in wireless networks as a mixed integer linear programming problem and then propose a Lagrangean relaxation based algorithm to solve this problem. By leveraging on the information from the Lagrangean multiplier, we could construct more power efficient routing paths. Numerical results demonstrate that the proposed approach outperforms the existing approaches for broadcast,multicast, and unicast communications.