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Lim, Soo,Kang, Seon Mee,Shin, Hayley,Lee, Hak Jong,Won Yoon, Ji,Yu, Sung Hoon,Kim, So-Youn,Yoo, Soo Young,Jung, Hye Seung,Park, Kyong Soo,Ryu, Jun Oh,Jang, Hak C. American Diabetes Association 2011 Diabetes care Vol.34 No.2
<P><B>OBJECTIVE</B></P><P>To improve quality and efficiency of care for elderly patients with type 2 diabetes, we introduced elderly-friendly strategies to the clinical decision support system (CDSS)-based ubiquitous healthcare (u-healthcare<B>)</B> service, which is an individualized health management system using advanced medical information technology.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>We conducted a 6-month randomized, controlled clinical trial involving 144 patients aged >60 years. Participants were randomly assigned to receive routine care (control, <I>n</I> = 48), to the self-monitored blood glucose (SMBG, <I>n</I> = 47) group, or to the u-healthcare group (<I>n</I> = 49). The primary end point was the proportion of patients achieving A1C <7% without hypoglycemia at 6 months. U-healthcare system refers to an individualized medical service in which medical instructions are given through the patient’s mobile phone. Patients receive a glucometer with a public switched telephone network-connected cradle that automatically transfers test results to a hospital-based server. Once the data are transferred to the server, an automated system, the CDSS rule engine, generates and sends patient-specific messages by mobile phone.</P><P><B>RESULTS</B></P><P>After 6 months of follow-up, the mean A1C level was significantly decreased from 7.8 ± 1.3% to 7.4 ± 1.0% (<I>P</I> < 0.001) in the u-healthcare group and from 7.9 ± 1.0% to 7.7 ± 1.0% (<I>P</I> = 0.020) in the SMBG group, compared with 7.9 ± 0.8% to 7.8 ± 1.0% (<I>P</I> = 0.274) in the control group. The proportion of patients with A1C <7% without hypoglycemia was 30.6% in the u-healthcare group, 23.4% in the SMBG group (23.4%), and 14.0% in the control group (<I>P <</I> 0.05).</P><P><B>CONCLUSIONS</B></P><P>The CDSS-based u-healthcare service achieved better glycemic control with less hypoglycemia than SMBG and routine care and may provide effective and safe diabetes management in the elderly diabetic patients.</P>
Lim, Soo,Kim, Jung Hee,Yoon, Ji Won,Kang, Seon Mee,Choi, Sung Hee,Park, Young Joo,Kim, Ki Woong,Lim, Jae Young,Park, Kyong Soo,Jang, Hak Chul American Diabetes Association 2010 Diabetes care Vol.33 No.7
<P><B>OBJECTIVE</B></P><P>We investigated the prevalence of sarcopenic obesity (SO) and its relationship with metabolic syndrome in a community-based elderly cohort in Korea.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>In this study, 287 men and 278 women aged 65 or older were recruited. Sarcopenia was defined as the appendicular skeletal muscle mass (ASM) divided by height squared (Ht<SUP>2</SUP>) (kg/m<SUP>2</SUP>) or by weight (Wt) (%) of <1 SD below the sex-specific mean for young adults. Obesity was defined as a visceral fat area ≥100 cm<SUP>2</SUP>.</P><P><B>RESULTS</B></P><P>The prevalence of SO was 16.7% in men and 5.7% in women with sarcopenia defined by ASM/Ht<SUP>2</SUP>; however, it was 35.1% in men and 48.1% in women by ASM/Wt. Using ASM/Wt, the homeostasis model assessment of insulin resistance of subjects with SO was higher and they were at higher risk for metabolic syndrome (odds ratio [OR] 8.28 [95% CI 4.45–15.40]) than the obese (5.51 [2.81–10.80]) or sarcopenic group (2.64 [1.08–6.44]).</P><P><B>CONCLUSIONS</B></P><P>SO defined by ASM/Wt was more closely associated with metabolic syndrome than either sarcopenia or obesity alone.</P>
Lim, Soo,Shin, Hayley,Song, Jung Han,Kwak, Soo Heon,Kang, Seon Mee,Won Yoon, Ji,Choi, Sung Hee,Cho, Sung Il,Park, Kyong Soo,Lee, Hong Kyu,Jang, Hak Chul,Koh, Kwang Kon American Diabetes Association 2011 Diabetes care Vol.34 No.6
<P><B>OBJECTIVE</B></P><P>The number of people with metabolic syndrome is increasing worldwide, and changes in socioenvironmental factors contribute to this increase. Therefore, investigation of changes in metabolic syndrome and its components in South Korea, where rapid socioenvironmental changes have occurred in recent years, would be foundational in setting up an effective strategy for reducing this increasing trend.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>We compared the prevalence and pattern of metabolic syndrome among participants in the Korean National Health and Nutrition Examination Surveys for 1998, 2001, 2005, and 2007. In each survey, stratified, multistage, probability–sampling designs and weighting adjustments were conducted to represent the entire Korean population. The revised National Cholesterol Education Program criteria were used as the definition of metabolic syndrome. All biochemical parameters were measured in a central laboratory.</P><P><B>RESULTS</B></P><P>A total of 6,907 (mean ± SE age 45.0 ± 0.2 years), 4,536 (45.5 ± 0.2), 5,373 (47.1 ± 0.2), and 2,890 (49.9 ± 0.3) Koreans over 20 years of age have participated in the studies in 1998, 2001, 2005, and 2007, respectively. The age-adjusted prevalence of metabolic syndrome increased significantly from 24.9% in 1998, 29.2% in 2001, and 30.4% in 2005 to 31.3% in 2007. Among the five components, the level of low HDL cholesterol increased the most, by 13.8% over the 10 years. Abdominal obesity and hypertriglyceridemia followed, with 8.7 and 4.9% increases, respectively.</P><P><B>CONCLUSIONS</B></P><P>Because dyslipidemia and abdominal obesity were major factors in increasing the prevalence of metabolic syndrome in Koreans for the past 10 years, lifestyle interventions should be conducted at the national level to reduce the burden and consequences of metabolic syndrome.</P>
Lim, Soo,Kang, Seon Mee,Kim, Kyoung Min,Moon, Jae Hoon,Choi, Sung Hee,Hwang, Hee,Jung, Hye Seung,Park, Kyong Soo,Ryu, Jun Oh,Jang, Hak Chul Springer International 2016 Acta diabetologica Vol.53 No.2
<P>In 2011, we demonstrated that an individualized health management system employing advanced medical information technology, designated ubiquitous (u)-healthcare, was helpful in achieving glycemic control without hypoglycemia in patients with diabetes. Following this, we generated a new multidisciplinary u-healthcare system by upgrading our clinical decision support system (CDSS) rule engine and integrating a physical activity-monitoring device and dietary feedback into a comprehensive package. In a randomized, controlled clinical trial, patients with type 2 diabetes aged over 60 years were assigned randomly to a self-monitored blood glucose (SMBG) group (N = 50) or u-healthcare group (N = 50) for 6 months. The primary endpoint was the proportion of patients achieving glycated hemoglobin (HbA(1c)) < 7 % without hypoglycemia. Changes in body composition and lipid profiles were also investigated. The u-healthcare group was educated to use a specially designed glucometer and an activity monitor that automatically transferred test results to a hospital-based server. An automated CDSS rule engine generated and sent patient-specific messages about glucose, diet, and physical activity to their mobile phones and a Web site. After 6 months of follow-up, the HbA(1c) level was significantly decreased in the u-healthcare group [8.0 +/- A 0.7 % (64.2 +/- A 8.8 mmol/mol) to 7.3 +/- A 0.9 % (56.7 +/- A 9.9 mmol/mol)] compared with the SMBG group [8.1 +/- A 0.8 % (64.9 +/- A 9.1 mmol/mol) to 7.9 +/- A 1.2 % (63.2 +/- A 12.3 mmol/mol)] (P < 0.01). The proportion of patients with HbA(1c) < 7 % without hypoglycemia was greater in the u-healthcare group (26 %) than in the SMBG group (12 %; P < 0.05). Body fat mass decreased and lipid profiles improved in the u-healthcare group but not in the SMBG group. This u-healthcare service provided effective management for older patients with type 2 diabetes (ClinicalTrial.Gov: NCT01137058).</P>
Lim, Soo,Shin, Hayley,Kim, Min Ju,Ahn, Hwa Young,Kang, Seon Mee,Yoon, Ji Won,Choi, Sung Hee,Kim, Ki Woong,Song, Jung Han,Choi, Sang Il,Chun, Eun Ju,Shin, Chan Soo,Park, Kyong Soo,Jang, Hak Chul Issued for the Endocrine Society by the Williams W 2012 The Journal of clinical endocrinology & metabolism Vol.97 No.1
<P>Recent studies suggest an association between vitamin D activity and cardiometabolic risk.</P>
Bang, Soo-Mee,Lee, Jeong-Ok,Kim, Yu Jung,Lee, Keun-Wook,Lim, Soo,Kim, Jee Hyun,Park, Young Joo,Chin, Ho Jun,Kim, Ki Woong,Jang, Hak-Chul,Lee, Jong Seok Springer International 2013 Annals of hematology Vol.92 No.1
<P>This study was planned to investigate the prevalence and risk factors of anemia and its impact on health-related quality of life and activities of daily living (ADL) in elderly Koreans. Of the 1,118 randomly sampled elderly Koreans aged 65?years or older living in Seongnam, Korea, on Aug. 1, 2005, we estimated the prevalence of anemia from 695 responders. We investigated the risk factors of anemia using a merged sample of this random sample and 270 volunteers enrolled from Seongnam residents aged 85?years or older. We diagnosed anemia according to the World Health Organization criteria. The estimated age- and gender-standardized prevalence of anemia was 8.33?% for the overall random sample (95?% confidence intervals (CI) 6.28-10.39), 10.58?% in men (95?% CI 7.09-14.07), and 6.85?% in women (95?% CI 4.37-9.34). The identified risk factors were age 80?years, male, iron deficiency, history of stroke, renal dysfunction, and metabolic syndrome. Anemia was associated with impairment in physical functioning (p?=?0.031) and instrumental ADL (p?<?0.001). This is the first report about anemia's prevalence in community-dwelling Korean elders, adjusted and standardized according to the city's and nation's population. Timely diagnosis of anemia and correction of its treatable cause may improve QOL and ADL in elderly individuals.</P>
임수미 ( Soo Mee Lim ),최선은 ( Sun Eun Choi ) 대한보건협회 2013 대한보건연구 Vol.39 No.2
Objectives: Salmonella spp. are one of zoonosis in worldwide, which are well known as a primary cause of infectious enterocolitis and food poisoning. Salmonella spp. are sort of Gram negative bacillus and can occur enterocolitis, hyperthermy, bacteremia, cholera morbus, focal infection, typhus and etc. The aim of this study was to discover new antibacterial activity resorces(material) from natural materials to cure Salmonela spp., a primary cause of intractable disease. Methods: This study was performed with 3 kinds of Salmonella spp. to measure antibacterial effects using minimum inhibitory concentration(MIC) assay to Acer ginnala stem extracts that extracted by 80% acetone and 8 fractions that fracted by liquid column chromatography and thin layer chromatography(TLC). Results: This experiment measured antibacterial effects of herbal specimen and Ampicillin to 3 sorts of Salmonella spp., [S. typhi (ATCC 19943), S. gallinarum (ATCC9184) and S. paratyphi A]. As a result of this experiment, the bark extract from Acer ginnala Maxim., Fr.5 and 6 generally showed superior antibacterial effect compare with Ampicillin and even showed much superior antibacterial effect for particular Salmonella spp[S. gallinarum (ATCC9184)]. Conclusion: The stems of Acer ginnala Maxim. which have superior antibacterial effect can be expected to develop as various fuctional food and cosmetic resources.