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RISS 인기검색어
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- 저자 : Sobolewski, Andrzej L. (검색결과 5 건)
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Sobolewski, Cyril,Rhim, Jiyun,Legrand, Noé,mie,Muller, Florian,Cerella, Claudia,Mack, Fabienne,Chateauvieux, Sé,bastien,Kim, Jeoung-Gyun,Yoon, Ah-Young,Kim, Kyu-Won,Dicato, Mario,Diederich American Society for Pharmacology and Experimental 2015 The Journal of Pharmacology and Experimental Thera Vol.355 No.2
<P>Cyclooxygenase-2 (COX-2) is an essential regulator of cancer promotion and progression. Extensive efforts to target this enzyme have been developed to reduce growth of cancer cells for chemopreventive and therapeutic reasons. In this context, cyclooxygenase-2 inhibitors present interesting antitumor effects. However, inhibition of COX-2 by anti-COX-2 compounds such as celecoxib was recently associated with detrimental cardiovascular side effects limiting their clinical use. As many anticancer effects of celecoxib are COX-2 independent, analogs such as 2,5-dimethyl-celecoxib (DMC), which lacks COX-2-inhibitory activity, represent a promising alternative strategy. In this study, we investigated the effect of this molecule on growth of hematologic cancer cell lines (U937, Jurkat, Hel, Raji, and K562). We found that this molecule is able to reduce the growth and induces apoptosis more efficiently than celecoxib in all the leukemic cell lines tested. Cell death was associated with downregulation of Mcl-1 protein expression. We also found that DMC induces endoplasmic reticulum stress, which is associated with a decreased of GRP78 protein expression and an alteration of cell cycle progression at the G1/S transition in U937 cells. Accordingly, typical downregulation of c-Myc and cyclin D1 and an upregulation of p27 were observed. Interestingly, for shorter time points, an alteration of mitotic progression, associated with the downregulation of survivin protein expression was observed. Altogether, our data provide new evidence about the mode of action of this compound on hematologic malignancies.</P>
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Effect of conformational flexibility on photophysics of bis-coumarins
Kielesiń,ski, Łukasz,Gryko, Daniel T.,Sobolewski, Andrzej L.,Morawski, Olaf W. The Royal Society of Chemistry 2018 Physical chemistry chemical physics Vol.20 No.21
<P>The fluorescence intensity of bis-coumarins linked <I>via</I> CONH and COO functionalities are shown to exhibit a strong dependance on solvent polarity. The presence of the intramolecular hydrogen bond between the CO oxygen atom of coumarin and amide-NH moieties reduces the number of thermodynamically populated conformations in both ground and electronically excited states and an <I>anti</I>-arrangement of coumarin units is favored. Additionally, the rigidity of the linker raises the barrier to the conical intersection with the ground state, and in non-polar solvents strong fluorescence is observed. Although changing the CONH linking position from 3-7′ to 3-6′, does not remarkably affect the photophysics, replacement with a flexible ester linker allows the molecule a greater degree of conformational freedom due to the absence of the intramolecular hydrogen bonding interaction. The photophysical effect of this is the appearance of two fluorescence bands, the relative intensity and spectral positions of which are sensitive to the environment. Theoretical explorations of the excited-state potential energy surfaces performed with the aid of the ADC(2) <I>ab initio</I> electronic structure theory method revealed an exceptional wealth of concomitant photophysical processes. In particular, two channels for radiationless deactivation of the excited state were found; the first is related to the inter-ring twist of the coumarin units, and the second is associated with the excited-state intramolecular proton-transfer (ESIPT) from the CONH linker to the coumarin core.</P>
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Stefan Baj,Tomasz Krawczyk,Aleksandra Dąbrowska,Agnieszka Siewniak,Aleksander Sobolewski 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.11
The solubility of carbon dioxide at atmospheric pressure in aqueous mixtures of 1,3-alkyl substituted imidazolium ionic liquids (ILs) containing carboxylic anions was studied. The ILs showed increased solubility of CO2 with decreasing water concentration. The relationship between the CO2 concentration in solution and the mole fraction of water in the ILs describes a sigmoidal curve. The regression constants of a logistic function were used to quantitatively assess the absorbent capacity and the effect of water on CO2 absorption. ILs containing the most basic anions, such as pivalate, propionate and acetate, had the best properties. It was observed that the impact of water on absorption primarily depended on the cation structure. The best absorption performance was observed for 1,3-dibutylimidazolium pivalate and 1-butyl-3-methyl imidazolium acetate.
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Irene Escudero-Martínez,Magnus Thorén,Peter Ringleb,Ana Paiva Nunes,Manuel Cappellari,Viiu-Marika Rand,Piotr Sobolewski,Jose Egido,Danilo Toni,Shih-Yin Chen,Nicole Tsao,Niaz Ahmed 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.1
Background and Purpose Cerebral edema (CED) in ischemic stroke can worsen prognosis and about 70% of patients who develop severe CED die if treated conservatively. We aimed to describe incidence, risk factors and outcomes of CED in patients with extensive ischemia. Methods Oservational study based on Safe Implementation of Treatments in Stroke-International Stroke Treatment Registry (2003–2019). Severe hemispheric syndrome (SHS) at baseline and persistent SHS (pSHS) at 24 hours were defined as National Institutes of Health Stroke Score (NIHSS) >15. Outcomes were moderate/severe CED detected by neuroimaging, functional independence (modified Rankin Scale 0–2) and death at 90 days. Results Patients (n=8,560) presented with SHS and developed pSHS at 24 hours; 82.2% received intravenous thrombolysis (IVT), 10.5% IVT+thrombectomy, and 7.3% thrombectomy alone. Median age was 77 and NIHSS 21. Of 7,949 patients with CED data, 3,780 (47.6%) had any CED and 2,297 (28.9%) moderate/severe CED. In the multivariable analysis, age <50 years (relative risk [RR], 1.56), signs of acute infarct (RR, 1.29), hyperdense artery sign (RR, 1.39), blood glucose >128.5 mg/dL (RR, 1.21), and decreased level of consciousness (RR, 1.14) were associated with moderate/severe CED (for all P<0.05). Patients with moderate/severe CED had lower odds to achieve functional Independence (adjusted odds ratio [aOR], 0.35; 95% confidence interval [CI], 0.23 to 0.55) and higher odds of death at 90 days (aOR, 2.54; 95% CI, 2.14 to 3.02). Conclusion In patients with extensive ischemia, the most important predictors for moderate/ severe CED were age <50, high blood glucose, signs of acute infarct, hyperdense artery on baseline scans, and decreased level of consciousness. CED was associated with worse functional outcome and a higher risk of death at 3 months.
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