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68Ga‑DOTANOC PET/CT for Screening and Surveillance of Von Hippel‑Lindau (VHL) disease
Shamim Ahmed Shamim,Geetanjali Arora,Naresh Kumar,Jhangir Hussain,Shreya Datta Gupta,Arun Raj ST,Kritin Shankar,Alpesh Goyal,Rajesh Khadgawat,Sambit Sagar,Chandrasekhar Bal 대한핵의학회 2023 핵의학 분자영상 Vol.57 No.5
Purpose Hereditary tumor syndrome Von Hippel-Lindau (VHL) disease is characterized by various benign and malignanttumors that are known to express somatostatin receptors (SSTR). We evaluated the role of 68Ga-DOTANOC PET/CT scan inpatients with positive germline mutation of the VHL gene, presented initially or on follow-up, for the detection of recurrentor synchronous/metachronous lesions. Methods Fourteen patients (8 males; 6 females) with mean age 30 ± 9.86 years were retrospectively analyzed, were testedpositive for VHL on gene dosage analysis, and underwent 68 Ga-DOTANOC PET/CT scan for disease evaluation. The numberand site of lesions were determined. The tracer uptake was analyzed semi-quantitatively by calculating the maximumstandardized uptake values (SUVmax) of lesion. Results Four of the 14 patients underwent scan for initial diagnosis as baseline, 6 patients for post-therapy disease status,and 4 patients for initial diagnosis as well as follow-up evaluation of the disease. A total of 67 lesions were detected in 14patients. The sites of lesions were cerebellar/vertebral/spinal (17; mean SUVmax = 7.85); pancreatic neuroendocrine tumor(NET) (11; mean SUVmax = 20.64); retina (3; mean SUVmax = 10.46); pheochromocytoma (10; mean SUVmax = 16.32);paragangliomas (3; mean SUVmax = 10.65); pancreatic cyst (9; mean SUVmax = 2.54); and renal cyst (8; mean SUVmax= 1.56) and miscellaneous lesions constituted 6 lesions. Conclusion Our results show that 68 Ga-DOTANOC PET/CT may be a useful modality for screening and follow-up of associatedtumors in patients with germline gene mutation for VHL. It can be used as a one-stop imaging modality for VHL patientsand may substitute for separate radiological investigations, making it more convenient for patients in terms of time and cost.
Jwariya Shamim(Jwariya Shamim ),Athar Parvez Ansari(Athar Parvez Ansari ),Pankaj Goswami(Pankaj Goswami ),Seema Akbar(Seema Akbar ),Huzaifa Ansari(Huzaifa Ansari ),Abdul Wadud(Abdul Wadud ),Pervaiz Ah 셀메드 세포교정의약학회 2023 셀메드 (CellMed) Vol.13 No.6
Objectives:Cassia occidentalis L. is a weed belonging to the Caesalpiniaceae family. The root of this medicinal plant is used for the treatment of various ailments, including kidney diseases. The present study was aimed at evaluating the nephroprotective effects of HAE of the roots of Cassia occidentalis L. against gentamicin-induced renal toxicity in albino Wistar rats. Methods:The renal toxicity was induced by subcutaneous administration of gentamicin at 100 mg/kg in the rats belonging to the disease control and treatment groups from the 4th to the 8th day. The rats in the treatment group received HAE of the roots of Cassia occidentalis L. at 67 mg/kg b. w. orally for 8 days, while no treatment was given to the rats in the disease control and plain control groups. At the end of the experiment, renal biomarkers viz; s. creatinine, b. urea, and s. uric acid, were investigated. The histopathological examination of the kidney specimens was also carried out. Results:The results of the present study revealed that renal function biomarkers such as s. creatinine, b. urea, and s. uric acid were significantly reduced in the rats of the treatment group as compared to those of the disease control group. Moreover, the histoarchitecture reports of the treatment group’s kidney specimens showed significant improvements. Conclusion:The results suggested that the HAE of Cassia occidentalis L. roots promisingly prevented kidney injury in gentamicin-induced nephrotoxic rats. This effect might be due to improved clearance of gentamicin from the renal tubule and decreased generation of reactive oxygen species (ROS).
Theranostics in Bangladesh: Current Status, Challenges, and Future Perspective
Shamim Momtaz Ferdousi Begum,Lutfun Nisa,Azmal K. Sarker 대한핵의학회 2019 핵의학 분자영상 Vol.53 No.2
Background and Current Status of Theranostics Therapeutic nuclear medicine (NM) in Bangladesh began in the early 1980s with the application of radioactive iodine for treatment of thyroid cancer and primary hyperthyroidism. Since then, NM practice has remarkably developed in the country with the advancement of instrumentation, radiopharmacy, and information technology. The government took the initiative to establish four PET-CTcenters at different NMcenters, including one at the National Institute of Nuclear Medicine and Allied Sciences (NINMAS). A further development is the installation of a cyclotron center (18-MeV cyclotron) at NINMAS by the government’s fund. Currently, NM is providing good health services to oncology patients throughout the country. More than 20 NM centers are functioning in different parts of the country, and therapeutic NM has an important place. However, conventional radioactive iodine still remains the major theranostic application. Challenges and Future Perspective The expansion and development of therapeutic NM for other cancers have been limited due to a number of challenging factors. A brief overview of the history and current status ofNMin Bangladesh is presented here with an examination of factors that pose as obstacles to the introduction and development of new therapeutic technologies. Finally, future perspectives are discussed with ways to mitigate existing problems and challenges.
Shamim-Ara Pervin,김갑진,Arun Anand Prabu,이용택 한국고분자학회 2015 Macromolecular Research Vol.23 No.1
Poly(vinylidene fluoride) (PVDF) based water purification membranes exhibit excellent thermal stability andchemical resistance, but also possess inherent drawbacks such as severe membrane fouling, lower separation efficiency andwater flux due to its hydrophobic nature. In the present study, we attempted to enhance the hydrophilicity of PVDFmembranes by treating with varying content (0 to 3 wt%) of partially sulfonated poly(1,4-phenylene sulfide) (sPPS)component using phase-inversion process. Compared to neat PVDF membrane, the PVDF/sPPS blend membranesexhibited typical asymmetric morphology with larger finger-like pores, efficient distribution of hydrophilic SO3-groups and decreasing water contact angle (WCA) upto 62o (77o for neat PVDF) as confirmed from scanning electronmicroscope (SEM), energy dispersive X-ray spectroscopy (EDX) and contact-angle measurements, respectively. Studies carried out for pure water flux (880 L/m2h) and blood serum albumin (BSA) solution flux (185 L/m2h)confirmed the enhanced permeability and higher fouling resistance for PVDF-sPPS (3 wt% sPPS) membranescompared to neat PVDF membrane (175 L/m2h and 63 L/m2h, respectively), though the BSA flux decreased withan increase in the filtration time due to membrane fouling. Compared to the total organic carbon (TOC) values ofpoly(ethylene oxide) (PEO) aqueous solutions before permeation (189.9 mg/L for Mw=100,000 and 75.68 mg/L forMw=300,000), TOC of neat PVDF membrane decreased to 15 mg/L for Mw= 100,000 and 5 mg/L for Mw=300,000. Withincreasing sPPS content, the TOC values showed an increasing trend due to their increasing pore size. Overall, theincorporation of sPPS in PVDF membrane lowered the WCA, enhanced fouling resistance and improved its permeabilityand selectivity, which exemplifies the importance of this study.